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中华乳腺病杂志(电子版) ›› 2023, Vol. 17 ›› Issue (03) : 187 -189. doi: 10.3877/cma.j.issn.1674-0807.2023.03.011

病例报告

注射用曲妥珠单克隆抗体致重度血小板减少一例
韩萌萌, 冯雪园, 马宁()   
  1. 071000 保定市第一中心医院乳腺外科
  • 收稿日期:2022-08-21 出版日期:2023-06-01
  • 通信作者: 马宁

Severe trastuzumab-related thrombocytopenia: one case report

Mengmeng Han, Xueyuan Feng, Ning Ma()   

  • Received:2022-08-21 Published:2023-06-01
  • Corresponding author: Ning Ma
引用本文:

韩萌萌, 冯雪园, 马宁. 注射用曲妥珠单克隆抗体致重度血小板减少一例[J/OL]. 中华乳腺病杂志(电子版), 2023, 17(03): 187-189.

Mengmeng Han, Xueyuan Feng, Ning Ma. Severe trastuzumab-related thrombocytopenia: one case report[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2023, 17(03): 187-189.

注射用曲妥珠单克隆抗体(赫赛汀)是一种重组人源化单克隆抗体,可选择性地作用于HER-2分子的胞外部位,通过阻断HER-2而产生抗肿瘤作用。目前,曲妥珠单克隆抗体已成为HER-2阳性乳腺癌患者的标准治疗方案[1]。有关赫赛汀致血小板减少的报道很少。汉曲优是赫赛汀的生物类似药,于2020年在中国上市,目前鲜有其致重度血小板减少的个案报道。本文报道了一例汉曲优致重度血小板减少的患者,供同道参考。

图1 注射用曲妥珠单克隆抗体致血小板减少患者治疗期间外周血血小板计数变化图
表1 文献报道的曲妥珠单克隆抗体致血小板减少症病例临床资料
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