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中华乳腺病杂志(电子版) ›› 2023, Vol. 17 ›› Issue (05) : 290 -293. doi: 10.3877/cma.j.issn.1674-0807.2023.05.006

综述

三阴性乳腺癌分子遗传学及临床特征研究进展
康一坤, 袁芃()   
  1. 100730 国家老年医学中心/国家卫生健康委临床检验中心/中国医学科学院老年医学研究院/北京医院肿瘤内科
    100021 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院特需医疗部
  • 收稿日期:2022-01-25 出版日期:2023-10-01
  • 通信作者: 袁芃
  • 基金资助:
    国家自然科学基金资助项目(81672634、82172650); 中国医学科学院临床转化与医学研究基金项目(12019XK320071)

Molecular genetics and clinical characteristics of triple negative breast cancer

Yikun Kang, Peng Yuan()   

  • Received:2022-01-25 Published:2023-10-01
  • Corresponding author: Peng Yuan
引用本文:

康一坤, 袁芃. 三阴性乳腺癌分子遗传学及临床特征研究进展[J/OL]. 中华乳腺病杂志(电子版), 2023, 17(05): 290-293.

Yikun Kang, Peng Yuan. Molecular genetics and clinical characteristics of triple negative breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2023, 17(05): 290-293.

三阴性乳腺癌(TNBC)是一种特殊类型的乳腺癌,约占乳腺癌的10%~21%,其临床表现和分子生物学特征有别于其他分子分型乳腺癌。TNBC的发病年龄相对年轻,其发生、发展可能与种族、遗传、妊娠、月经、用药、生活方式等因素有关。TNBC复发和转移率较高,预后较差,因其缺乏特异性分子靶点,临床治疗手段有限。本研究整理了TNBC的分子遗传学、流行病学和临床特征3个方面的文献进展,旨在为TNBC的临床诊疗提供参考依据。

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