[1] |
Ciccarelli FD, Acciarito A, Alberti S. Large and diverse numbers of human diseases with HIKE mutations[J]. Hum Mol Genet,2000,9(6):1001-1007.
|
[2] |
Ripani E, Sacchetti A, Corda D, et al. Human Trop-2 is a tumor-associated calcium signal transducer[J]. Int J Cancer,1998,76(5):671-676.
|
[3] |
Lipinski M, Parks DR, Rouse RV, et al. Human trophoblast cell-surface antigens defined by monoclonal antibodies[J]. Proc Natl Acad Sci U S A,1981,78(8):5147-5150.
|
[4] |
Alberti S, Miotti S, Stella M, et al. Biochemical characterization of Trop-2, a cell surface molecule expressed by human carcinomas: formal proof that the monoclonal antibodies T16 and MOv-16 recognize Trop-2[J]. Hybridoma,1992,11(5):539-545.
|
[5] |
Trerotola M, Cantanelli P, Guerra E, et al. Upregulation of Trop-2 quantitatively stimulates human cancer growth[J]. Oncogene,2013,32(2):222-233.
|
[6] |
Shvartsur A, Bonavida B. Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications[J]. Genes Cancer,2015,6(3-4):84-105.
|
[7] |
Stoyanova T, Goldstein AS, Cai H, et al. Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via beta-catenin signaling[J]. Genes Dev,2012,26(20):2271-2285.
|
[8] |
Xu P, Zhao Y, Liu K, et al. Prognostic role and clinical significance of trophoblast cell surface antigen 2 in various carcinomas[J]. Cancer Manag Res,2017,9:821-837.
|
[9] |
Zaman S, Jadid H, Denson AC, et al. Targeting Trop-2 in solid tumors: future prospects[J]. Onco Targets Ther,2019,12:1781-1790.
|
[10] |
Zhang L, Yang G, Zhang R, et al. Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells[J]. Int J Oncol,2018,53(2):515-526.
|
[11] |
陆莉. Trop-2基因在乳腺癌细胞侵袭中作用及机制探讨[D]. 江苏大学,2013.
|
[12] |
Huang H, Groth J, Sossey-Alaoui K, et al. Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors[J]. Clin Cancer Res,2005,11(12):4357-4364.
|
[13] |
Son S, Shin S, Rao NV, et al. Anti-Trop2 antibody-conjugated bioreducible nanoparticles for targeted triple negative breast cancer therapy[J]. Int J Biol Macromol,2018,110:406-415.
|
[14] |
Bardia A, Mayer I A, Diamond JR, et al. Efficacy and safety of anti-Trop-2 antibody drug conjugate Sacituzumab Govitecan (IMMU-132) in heavily pretreated patients with metastatic triple-negative breast cancer[J]. J Clin Oncol,2017,35(19):2141-2148.
|
[15] |
Mojica WD, Brandwein-Weber M, Korangy EA. A case of metastatic lobular carcinoma with overexpression of Trop-2: Implications for the consideration of novel therapeutics[J]. Breast J,2017,23(6):757-759.
|
[16] |
Vranic S, Palazzo J, Sanati S, et al. Potential novel therapy targets in neuroendocrine carcinomas of the breast[J]. Clin Breast Cancer,2019,19(2):131-136.
|
[17] |
Zhao W, Kuai X, Zhou X, et al. Trop2 is a potential biomarker for the promotion of EMT in human breast cancer[J]. Oncol Rep,2018,40(2):759-766.
|
[18] |
陆莉,崔飞伦,肖秀娣,等. 乳腺癌组织中Trop-2蛋白的表达及意义[J]. 医学信息,2014(1):98-99.
|
[19] |
Oyama M, Nagashima T, Suzuki T, et al. Integrated quantitative analysis of the phosphoproteome and transcriptome in tamoxifen-resistant breast cancer[J]. J Biol Chem,2011,286(1):818-829.
|
[20] |
Wu M, Liu L, Chan C. Identification of novel targets for breast cancer by exploring gene switches on a genome scale[J]. BMC Genomics,2011,12:547.
|
[21] |
Guerra E, Trerotola M, Tripaldi R, et al. Trop-2 induces tumor growth through AKT and determines sensitivity to AKT inhibitors[J]. Clin Cancer Res,2016,22(16):4197-4205.
|
[22] |
Starodub AN, Ocean AJ, Shah MA, et al. First-in-human trial of a novel anti-Trop-2 antibody-SN-38 conjugate, Sacituzumab Govitecan, for the treatment of diverse metastatic solid tumors[J]. Clin Cancer Res,2015,21(17):3870-3878.
|
[23] |
Goldenberg DM, Cardillo TM, Govindan SV, et al. Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC)[J]. Oncotarget,2015,6(26):22496-22512.
|
[24] |
Ocean AJ, Starodub AN, Bardia A, et al. Sacituzumab govitecan (IMMU-132), an anti-Trop-2-SN-38 antibody-drug conjugate for the treatment of diverse epithelial cancers: Safety and pharmacokinetics[J]. Cancer,2017,123(19):3843-3854.
|
[25] |
Zangardi ML, Spring LM, Nagayama A, et al. Sacituzumab for the treatment of triple-negative breast cancer: the poster child of future therapy?[J]. Expert Opin Investig Drugs,2019,28(2):107-112.
|
[26] |
Bardia A, Mayer IA, Vahdat LT, et al. Sacituzumab Govitecan-hziy in refractory metastatic triple-negative breast cancer[J]. N Engl J Med,2019,380(8):741-751.
|
[27] |
Cardillo TM, Sharkey RM, Rossi DL, et al. Synthetic ethality exploitation by an anti-Trop-2-SN-38 antibody-drug conjugate, IMMU-132, plus PARP inhibitors in BRCA1/2-wild-type triple-negative breast cancer[J]. Clin Cancer Res,2017,23(13):3405-3415.
|
[28] |
Chang CH, Wang Y, Zalath M, et al. Combining ABCG2 inhibitors with IMMU-132, an anti-Trop-2 antibody conjugate of SN-38, overcomes resistance to SN-38 in breast and gastric cancers[J]. Mol Cancer Ther,2016,15(8):1910-1919.
|
[29] |
Liu D, Cardillo TM, Wang Y, et al. Trop-2-targeting tetrakis-ranpirnase has potent antitumor activity against triple-negative breast cancer[J]. Mol Cancer,2014,13:53.
|
[30] |
Strop P, Tran TT, Dorywalska M, et al. RN927C, site-specific Trop-2 antibody-drug conjugate (ADC) with enhanced stability, is highly efficacious in preclinical solid tumor models[J]. Mol Cancer Ther,2016,15(11):2698-2708.
|
[31] |
King GT, Eaton KD, Beagle BR, et al. A phase 1, dose-escalation study of PF-06664178, an anti-Trop-2/Aur0101 antibody-drug conjugate in patients with advanced or metastatic solid tumors[J]. Invest New Drugs,2018,36(5):836-847.
|
[32] |
Govindan SV, Stein R, Qu Z, et al. Preclinical therapy of breast cancer with a radioiodinated humanized anti-EGP-1 monoclonal antibody: advantage of a residualizing iodine radiolabel[J]. Breast Cancer Res Treat,2004,84(2):173-182.
|
[33] |
Sharkey RM, van Rij CM, Karacay H, et al. A new Tri-Fab bispecific antibody for pretargeting Trop-2-expressing epithelial cancers[J]. J Nucl Med,2012,53(10):1625-1632.
|
[34] |
van Rij CM, Lutje S, Frielink C, et al. Pretargeted immuno-PET and radioimmunotherapy of prostate cancer with an anti-TROP-2 x anti-HSG bispecific antibody[J]. Eur J Nucl Med Mol Imaging,2013,40(9):1377-1383.
|
[35] |
Saverio A.Anti-trop-2 monoclonal antibodies and uses thereof in the treatment and diagnosis of tumors:US,13/146012[P].2012-01-03.
|
[36] |
Lin H, Zhang H, Wang J, et al. A novel human Fab antibody for Trop2 inhibits breast cancer growth in vitro and in vivo[J]. Int J Cancer,2014,134(5):1239-1249.
|
[37] |
Chang CH, Wang Y, Li R, et al. Combination herapy with ispecific ntibodies and PD-1 lockade nhances the ntitumor otency of T ells[J]. Cancer Res,2017,77(19):5384-5394.
|