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中华乳腺病杂志(电子版) ›› 2021, Vol. 15 ›› Issue (03) : 185 -187. doi: 10.3877/cma.j.issn.1674-0807.2021.03.011

综述

滋养细胞表面抗原2在乳腺癌中的表达及在靶向和免疫治疗中的价值
刘苗雨1, 刘淼1, 王殊1,()   
  1. 1. 100044 北京大学人民医院乳腺中心
  • 收稿日期:2019-07-15 出版日期:2021-07-01
  • 通信作者: 王殊

Expression of trophoblast cell-surface antigen 2 in breast cancer and its value in targeted therapy and immunotherapy

Miaoyu Liu1, Miao Liu1, Shu Wang1()   

  • Received:2019-07-15 Published:2021-07-01
  • Corresponding author: Shu Wang
引用本文:

刘苗雨, 刘淼, 王殊. 滋养细胞表面抗原2在乳腺癌中的表达及在靶向和免疫治疗中的价值[J/OL]. 中华乳腺病杂志(电子版), 2021, 15(03): 185-187.

Miaoyu Liu, Miao Liu, Shu Wang. Expression of trophoblast cell-surface antigen 2 in breast cancer and its value in targeted therapy and immunotherapy[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2021, 15(03): 185-187.

滋养细胞表面抗原2(Trop-2)是发现于人绒毛膜癌细胞系中的跨膜蛋白,已被证明在包括乳腺癌在内的多种肿瘤细胞中过表达。研究表明,Trop-2过表达可促进癌细胞生长、侵袭和增殖,进而导致肿瘤进展。Trop-2多表达于ER(-)、HER-2(+)乳腺癌及三阴性乳腺癌,与肿瘤的不良预后相关。靶向Trop-2的抗体药物偶联物IMMU-132在治疗难治性转移性三阴性乳腺癌患者的临床试验中取得了较好的成果,其他靶向Trop-2的治疗也取得了一定的进展,为乳腺癌的治疗提供了新思路。

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