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中华乳腺病杂志(电子版) ›› 2021, Vol. 15 ›› Issue (02) : 65 -70. doi: 10.3877/cma.j.issn.1674-0807.2021.02.001

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2020年圣安东尼奥乳腺癌研讨会更新解读
刘强1,(), 杨畅1   
  1. 1. 510220 广州,中山大学孙逸仙纪念医院乳腺外科
  • 收稿日期:2021-03-06 出版日期:2021-04-01
  • 通信作者: 刘强

Interpretation of updates in 2020 San Antonio Breast Cancer Symposium

Qiang Liu1,(), Chang Yang1   

  1. 1. Department of Breast Surgery, Sun Yat-sen Memorial Hospital, Guangzhou 510220, China
  • Received:2021-03-06 Published:2021-04-01
  • Corresponding author: Qiang Liu
引用本文:

刘强, 杨畅. 2020年圣安东尼奥乳腺癌研讨会更新解读[J]. 中华乳腺病杂志(电子版), 2021, 15(02): 65-70.

Qiang Liu, Chang Yang. Interpretation of updates in 2020 San Antonio Breast Cancer Symposium[J]. Chinese Journal of Breast Disease(Electronic Edition), 2021, 15(02): 65-70.

乳腺癌领域研究进展日新月异,临床治疗以循证医学为基础,逐渐向个体化、精准化方向发展。2020年圣安东尼奥乳腺癌研讨会虽第一次因疫情改为线上,但依旧精彩纷呈。现对该会议的最新进展进行汇报与总结,对医疗决策及未来的科学研究方向具有重要参考价值。

The researches on breast cancer make rapid progress nowadays. Clinical treatment is on the basis of evidence-based medicine and gradually develops in the direction of individualization and precision. Because of the COVID-19 pandemic, the 43th San Antonio Breast Cancer Symposium (SABCS) was launched online and the newest progress in the treatment of breast cancer was discussed. We summarized clinical advances reported in 2020 SABCS in order to provide references for medical decision making and future research directions pertaining to breast cancer.

表1 2020年圣安东尼奥乳腺癌研讨会相关临床试验
试验名称 试验阶段 试验药物名称(+联合治疗) 药物机制 入组(例) 临床试验编号
ALTERNATE试验[1] 3期 氟维司群 ER受体拮抗剂 1 473 NCT01953588
FELine试验[2] 2期 ribociclib(+来曲唑) CDK4/6抑制剂 121 NCT02712723
PALLAS试验[3] 3期 palbociclib(+AI或他莫昔芬) CDK4/6抑制剂 5 760 NCT 02513394
PENELOPE-B试验[4] 3期 palbociclib CDK4/6抑制剂 1 250 NCT 01864746
monarchE试验[5] 3期 abemaciclib(+AI或他莫昔芬) CDK4/6抑制剂 5 637 NCT 03155997
SOLAR-1试验[7] 3期 alpelisib(+氟维司群) PI3K α选择性抑制剂 572 NCT 02437318
PAKT试验[9] 2期 capivasertib(+紫杉醇) AKT抑制剂 140 NCT02423603
FAKTION试验[10] 2期 capivasertib(+氟维司群) AKT抑制剂 140 NCT01992952
CONTESSA试验[11] 3期 tesetaxel(+卡培他滨) 口服紫杉烷 685 NCT03326674
ENCORE301试验[13] 2期 entinostat(+依西美坦) 选择性HDAC抑制剂 130 NCT00676663
E2112试验[14] 2期 entinostat 选择性HDAC抑制剂 608 NCT02115282
KATHERINE试验[15] 3期 T-DM1(+帕妥珠单克隆抗体) HER-2靶向抗体偶联药物 1 486 NCT01772472
KAITLIN试验[16] 3期 T-DM1(+帕妥珠单克隆抗体) HER-2靶向抗体偶联药物 1 846 NCT 01966471
TRAIN-2试验[17] 3期 表柔比星(+5-氟尿嘧啶+环磷酰胺) 蒽环类药物 438 NCT01996267
HER-2 CLIMB试验[19] 3期 妥卡替尼(+卡培他滨+曲妥珠单克隆抗体) 口服酪氨酸激酶抑制剂 480 NCT 02614794
DESTINY-Breast01试验[20] 2期 trastuzumab deruxtecan 抗体偶联药物 253 NCT 03248492
KEYNOTE-522试验[22] 3期 pembrolizumab(+白蛋白紫杉醇+卡铂) PD-1抑制剂 1 174 NCT 03036488
Impassion031试验[23,24] 3期 atezolizumab(+白蛋白紫杉醇) PD-L1抑制剂 333 NCT 03197935
BRIGHTNess试验[25] 3期 铂类 化疗药物 634 NCT 02032277
GeparSixto试验[26] 2期 铂类 化疗药物 315 NCT 01426880
Impassion130试验[27] 3期 atezolizumab(+白蛋白紫杉醇) PD-L1抑制剂 902 NCT02425891
KEYNOTE-355试验[28] 3期 pembrolizumab(+白蛋白紫杉醇,紫杉醇或吉西他滨) PD-1抑制剂 847 NCT 02819518
ASCENT试验[31] 3期 sacituzumab govitecan 抗体偶联药物 529 NCT 02574455
LOTUS试验[32] 2期 ipatasertib(+紫杉醇) AKT抑制剂 124 NCT 02162719
IPATunity130试验[33] 3期 ipatasertib(+紫杉醇) AKT抑制剂 255 NCT 03337724
TBCRC 048试验[34] 2期 奥拉帕尼 PARP抑制剂 54 NCT03344965
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