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中华乳腺病杂志(电子版) ›› 2020, Vol. 14 ›› Issue (02) : 73 -77. doi: 10.3877/cma.j.issn.1674-0807.2020.02.003

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第42届圣安东尼奥乳腺癌研讨会报道:三阴性乳腺癌
袁芃1,()   
  1. 1. 100021 北京协和医学院国家癌症中心/国家肿瘤临床研究中心/中国医学科学院肿瘤医院特需医疗部
  • 收稿日期:2020-03-10 出版日期:2020-04-01
  • 通信作者: 袁芃

Reports on triple negative breast cancer in the 42nd San Antonio Breast Cancer Symposium

Peng Yuan1,()   

  1. 1. Department of VIP Medical Services, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  • Received:2020-03-10 Published:2020-04-01
  • Corresponding author: Peng Yuan
  • About author:
    Corresponding author: Yuan Peng, Email:
引用本文:

袁芃. 第42届圣安东尼奥乳腺癌研讨会报道:三阴性乳腺癌[J]. 中华乳腺病杂志(电子版), 2020, 14(02): 73-77.

Peng Yuan. Reports on triple negative breast cancer in the 42nd San Antonio Breast Cancer Symposium[J]. Chinese Journal of Breast Disease(Electronic Edition), 2020, 14(02): 73-77.

三阴性乳腺癌分化差、侵袭性高、易转移、预后差,近年来临床研究缺乏突破。2019年12月10~14日举行的第42届圣安东尼奥乳腺癌研讨会(SABCS)报道了三阴性乳腺癌在化疗、免疫治疗以及新的药物和新的药物组合上取得的相关进展,笔者就相关热点问题进行综述。

Triple negative breast cancer is characterized by low-grade differentiation, high invasiveness, easy metastasis and poor prognosis. Clinical researches have showed little breakthrough in recent years. The 42nd San Antonio Breast Cancer Symposium was held on December 10-14, 2019, covering latest progress in chemotherapy, immunotherapy, new drug development and drug combinations for triple negative breast cancer. In this article, we reviewed the relevant hot issues.

[1]
Waks AG, Winer EP. Breast cancer treatment: a review[J]. JAMA, 2019, 321(3):288-300.
[2]
Li J, Yu K, Pang D, et al. Adjuvant capecitabine in combination with docetaxel and cyclophosphamide plus epirubicin for triple-negative breast cancer (cbcsg010): An open-label, randomised, multicentre, phase 3 trial [C/OL]// The San Antonio Breast Cancer Symposium, San Antonio, 2019 [2019-12-11].

URL    
[3]
Mackelenbergh MV, Seither F, Möbus V, et al. Effects of capecitabine as part of neo-/adjuvant chemotherapy. A meta-analysis of individual patient data from 12 randomized trials including 15,457 patients [C/OL]// The San Antonio Breast Cancer Symposium, San Antonio,2019 [2019-12-11].

URL    
[4]
Schmid P, Adams S, Rugo HS, et al. Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer[J]. N Engl J Med, 2018, 379(22):2108-2121.
[5]
Nanda R, Liu MC, Yau C, et al. Effect of pembrolizumab plus neoadjuvant chemotherapy on pathologic complete response in women with early-stage breast cancer: an analysis of the ongoing phase 2 adaptively randomized I-SPY2 trial[EB/OL]. [2020-02-13].

URL    
[6]
Schmid P, Park YH, Ferreira M, et al. KEYNOTE-522 study of neoadjuvant pembrolizumab + chemotherapy vs placebo + chemotherapy, followed by adjuvant pembrolizumab vs placebo for early triple-negative breast cancer: pathologic complete response in key subgroups and by treatment exposure, residual cancer burden, and breast-conserving surgery [C/OL]// The San Antonio Breast Cancer Symposium, San Antonio,2019 [2019-12-12].

URL    
[7]
Gianni L, Huang CS, Egle D, et al. Pathologic complete response (pCR) to neoadjuvant treatment with or without atezolizumab in triple negative, early high-risk and locally advanced breast cancer. NeoTRIPaPDL1 Michelangelo randomized study [C/OL]// The San Antonio Breast Cancer Symposium, San Antonio,2019 [2019-12-12].

URL    
[8]
Ogiya R, Niikura N, Kumaki N, et al. Comparison of tumor-infiltrating lymphocytes between primary and metastatic tumors in breast cancer patients[J]. Cancer Sci, 2016, 107(12):1730-1735.
[9]
Loibl S, Untch M, Burchardi N, et al. A randomised phase Ⅱ study investigating durvalumab in addition to an anthracycline taxane-based neoadjuvant therapy in early triple-negative breast cancer: clinical results and biomarker analysis of GeparNuevo study[J]. Ann Oncol 2019, 30(8):1279-1288.
[10]
Pusztai L, Reisenbichler E, Bai Y, et al. Durvalumab (MEDI4736) concurrent with nab-paclitaxel and dose dense doxorubicin cyclophosphamide (ddAC) as neoadjuvant therapy for triple negative breast cancer (TNBC)[C/OL]// The San Antonio Breast Cancer Symposium, San Antonio,2019 [2019-12-11].

URL    
[11]
Gennari A, Stockler M, Puntoni M, et al. Duration of chemotherapy for metastatic breast cancer: a systematic review and meta-analysis of randomized clinical trials[J]. J Clin Oncol, 2011, 29(16):2144-2149.
[12]
Wu J, Waxman DJ. Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy[J]. Cancer Lett, 2018, 419:210-221.
[13]
Dalenc F, Garberis I, Filleron T, et al. Durvalumab compared to maintenance chemotherapy in patients with metastatic breast cancer: Results from phase Ⅱ randomized trial SAFIR02-IMMUNO [C/OL]// The San Antonio Breast Cancer Symposium, San Antonio, 2019 [2019-12-12].

URL    
[14]
Han H, Diab S, Alemany C, et al. Open label phase 1b/2 study of ladiratuzumab vedotin in combination with pembrolizumab for first-line treatment of patients with unresectable locally-advanced or metastatic triple-negative breast cancer [C/OL]// The San Antonio Breast Cancer Symposium, San Antonio, 2019 [2019-12-11].

URL    
[15]
Tolaney S, Blum J, Bondarenko I, et al. CONTESSA TRIO: A multinational, multicenter, phase 2 study of tesetaxel plus 3 different PD-(L)1 inhibitors in patients with metastatic triple-negative breast cancer (TNBC) and tesetaxel monotherapy in elderly patients with HER2- metastatic breast cancer (MBC) [C/OL]// The San Antonio Breast Cancer Symposium, San Antonio, 2019 [2019-12-11].

URL    
[16]
Krop I, Masuda N, Kogawa T, et al. Phase 1/2 first-in-human study of U3-1402, an anti-human epidermal growth factor receptor 3 (HER3) antibody-drug conjugate, in HER3-expressing advanced/unresectable or metastatic breast cancer, including those with triple negative breast cancer (TNBC) or HER3-low disease [C/OL]// The San Antonio Breast Cancer Symposium, San Antonio, 2019 [2019-12-11].

URL    
[17]
Rugo H, Chow LW, Cortes J, et al. Phase 3, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of adagloxad simolenin (OBI-822) and OBI-821 treatment in patients with early-stage triple-negative breast cancer (TNBC) at high risk for recurrence [C/OL]// The San Antonio Breast Cancer Symposium, San Antonio, 2019 [2019-12-11].

URL    
[18]
Schmid P, Abraham J, Chan S, et al. Capivasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer: the PAKT trial[J]. J Clin Oncol, 2020, 38(5):423-433.
[19]
Schmid P, Cortes J, Robson M, et al. Capivasertib and paclitaxel in first-line treatment of patients with metastatic triple-negative breast cancer: A phase Ⅲ trial (CAPItello-290) [C/OL]// The San Antonio Breast Cancer Symposium, San Antonio, 2019[2019-12-12].

URL    
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