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中华乳腺病杂志(电子版) ›› 2023, Vol. 17 ›› Issue (05) : 318 -321. doi: 10.3877/cma.j.issn.1674-0807.2023.05.012

病例报告

乳腺癌患者辅助化疗后感染肺孢子菌一例
段燕, 郭欣, 吕慧芳, 王国利, 黄明光, 董英俊()   
  1. 030013 太原,山西省肿瘤医院/中国医学科学院肿瘤医院山西医院/山西医科大学附属肿瘤医院重症医学科
  • 收稿日期:2022-05-16 出版日期:2023-10-01
  • 通信作者: 董英俊

Pneumocystis carinii infection after neoadjuvant chemotherapy in breast cancer: one case report

Yan Duan, Xin Guo, Huifang Lyu   

  • Received:2022-05-16 Published:2023-10-01
引用本文:

段燕, 郭欣, 吕慧芳, 王国利, 黄明光, 董英俊. 乳腺癌患者辅助化疗后感染肺孢子菌一例[J/OL]. 中华乳腺病杂志(电子版), 2023, 17(05): 318-321.

Yan Duan, Xin Guo, Huifang Lyu. Pneumocystis carinii infection after neoadjuvant chemotherapy in breast cancer: one case report[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2023, 17(05): 318-321.

乳腺癌是全球女性最常见的恶性肿瘤之一。术后辅助化疗可以降低肿瘤复发率,提高总生存率,是乳腺癌综合治疗中非常重要的组成部分。但化疗药物及化疗过程中为预防或减轻消化道反应使用糖皮质激素可以造成免疫功能受损,是机会性病原体感染的高危因素。耶氏肺孢子菌肺炎是一种机会感染性肺部真菌病,起病隐匿,进展迅速,预后差。本文介绍1例接受剂量密集型AC-T(阿霉素、环磷酰胺续贯多西他赛)辅助化疗方案的早期乳腺癌患者感染耶氏肺孢子菌致死亡病例,总结乳腺癌患者接受化疗有可能感染肺孢子菌肺炎(pneumocystis carinii pneumonia,PCP)的高危因素、早期诊断和临床救治经验。

图1 肺孢子菌肺炎乳腺癌患者胸部CT图像 a图为治疗前,双肺透亮度减低,可见以肺门为中心的双肺弥漫性分布的磨玻璃影;b图为治疗后,显示渗出吸收,可见左下肺片状实变影
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