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中华乳腺病杂志(电子版) ›› 2024, Vol. 18 ›› Issue (06) : 371 -375. doi: 10.3877/cma.j.issn.1674-0807.2024.06.008

综述

非酒精性脂肪性肝病对乳腺癌发生发展及治疗的影响
朱文婷1, 顾鹏1, 孙星1,()   
  1. 1.201620 上海交通大学医学院附属第一人民医院普外科
  • 收稿日期:2023-11-22 出版日期:2024-12-01
  • 通信作者: 孙星

Impact of non-alcoholic fatty liver disease on the occurrence, development and treatment of breast cancer

Wenting Zhu, Peng Gu, Xing Sun()   

  • Received:2023-11-22 Published:2024-12-01
  • Corresponding author: Xing Sun
引用本文:

朱文婷, 顾鹏, 孙星. 非酒精性脂肪性肝病对乳腺癌发生发展及治疗的影响[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 371-375.

Wenting Zhu, Peng Gu, Xing Sun. Impact of non-alcoholic fatty liver disease on the occurrence, development and treatment of breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2024, 18(06): 371-375.

非酒精性脂肪性肝病(NAFLD)是一种常见的代谢性肝病,与肥胖、胰岛素抵抗和高血脂等代谢综合征密切相关。 近年来,研究发现NAFLD 不仅影响肝脏健康,还与乳腺癌的发生和进展密切相关。 NAFLD 通过多种机制增加乳腺癌的发生风险,包括雌激素水平的升高、慢性炎症反应的增强以及脂肪细胞因子的变化等。 在乳腺癌治疗方面,NAFLD 引起的肝功能变化可能导致药物代谢酶和转运蛋白的功能异常,进而影响化疗药物在体内的代谢。 此外,NAFLD 也可能对乳腺癌患者的内分泌治疗和免疫治疗产生影响,增加治疗相关的肝损伤风险。 因此,本文综述了NAFLD 对乳腺癌发生、发展及治疗的影响。

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