切换至 "中华医学电子期刊资源库"

中华乳腺病杂志(电子版) ›› 2022, Vol. 16 ›› Issue (06) : 365 -369. doi: 10.3877/cma.j.issn.1674-0807.2022.06.006

综述

激素受体阳性/人表皮生长因子受体2阴性晚期乳腺癌的治疗进展
张蓝心1, 高天琦1, 徐岭植1, 李曼1,()   
  1. 1. 116023 大连医科大学附属第二医院肿瘤内科
  • 收稿日期:2021-02-08 出版日期:2022-12-01
  • 通信作者: 李曼
  • 基金资助:
    国家自然科学基金项目(81872156); 辽宁省自然科学基金项目(2019-MS-096); 大连市科技创新基金项目(2019J13SN87)

Treatment of hormone receptor-positive / human epidermal growth factor receptor-2-negative advanced breast cancer

Lanxin Zhang1, Tianqi Gao1, Lingzhi Xu1   

  • Received:2021-02-08 Published:2022-12-01
引用本文:

张蓝心, 高天琦, 徐岭植, 李曼. 激素受体阳性/人表皮生长因子受体2阴性晚期乳腺癌的治疗进展[J]. 中华乳腺病杂志(电子版), 2022, 16(06): 365-369.

Lanxin Zhang, Tianqi Gao, Lingzhi Xu. Treatment of hormone receptor-positive / human epidermal growth factor receptor-2-negative advanced breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2022, 16(06): 365-369.

激素受体(HR)阳性/人表皮生长因子受体2(HER-2)阴性是常见的乳腺癌分子亚型。内分泌治疗作为其重要的治疗手段,已经被各大指南和专家共识推荐为一线策略(内脏危象或疾病快速进展除外)。随着细胞周期蛋白依赖激酶4/6抑制剂、组蛋白去乙酰化酶抑制剂、蛋白激酶B/哺乳动物雷帕霉素靶蛋白通路抑制剂等靶向药物的应用,HR阳性/HER-2阴性晚期乳腺癌进入了靶向治疗时代,临床医师逐步探索其标准化、精准化的治疗模式和深入。笔者从一线治疗策略、内分泌敏感患者中细胞周期依赖性激酶(CDK)4/6抑制剂的联合药物及病情进展后的解救治疗方案3个方面,总结了有关HR阳性/HER-2阴性晚期乳腺癌治疗的相关研究进展,供同行参考。

[1]
Waks AG, Winer EP. Breast cancer treatment: a review [J]. JAMA, 2019, 321(3): 288-300.
[2]
Park YH, Kim TY, Kim GM, et al. Palbociclib plus exemestane with gonadotropin-releasing hormone agonist versus capecitabine in premenopausal women with hormone receptor-positive, HER2-negative metastatic breast cancer (KCSG-BR15-10): a multicentre, open-label, randomised, phase 2 trial [J]. Lancet Oncol, 2019, 20(12): 1750-1759.
[3]
Martin M, Zielinski C, Ruiz-Borrego M, et al. Palbociclib in combination with endocrine therapy versus capecitabine in hormonal receptor-positive, human epidermal growth factor 2-negative, aromatase inhibitor-resistant metastatic breast cancer: a phase Ⅲ randomised controlled trial-PEARL [J]. Ann Oncol, 2021, 32(4): 488-499.
[4]
Finn RS, Martin M, Rugo HS, et al. Palbociclib and letrozole in advanced breast cancer [J]. N Engl J Med, 2016, 375(20): 1925-1936.
[5]
Hortobagyi GN, Stemmer SM, Burris HA, et al. Updated results from MONALEESA-2, a phase 3 trial of first-line ribociclib plus letrozole in hormone receptor-positive (HR+), HER2-negative (HER2-), advanced breast cancer [J]. Ann Oncol, 2018, 29(7): 1541-1547.
[6]
Hortobagyi GN, Stemmer SM, Burris HA, et al. Overall survival with ribociclib plus letrozole in advanced breast cancer [J]. N Engl J Med, 2022, 386(10): 942-950.
[7]
Goetz MP, Toi M, Campone M, et al. Monarch 3: abemaciclib as initial therapy for advanced breast cancer [J]. J Clin Oncol, 2017, 35(32): 3638-3646.
[8]
Tripathy D, Im SA, Colleoni M et al. Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial [J]. Lancet Oncol, 2018, 19(7): 904-915.
[9]
Lu YS, Im SA, Colleoni M, et al. Updated overall survival of ribociclib plus endocrine therapy versus endocrine therapy alone in pre-and perimenopausal patients with HR+/HER2-advanced breast cancer in MONALEESA-7: a phase Ⅲ randomized clinical trial [J]. Clin Cancer Res, 2022, 28(5): 851-859.
[10]
Slamon DJ, Neven P, Chia S, et al. Phase Ⅲ randomized study of ribociclib and fulvestrant in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: MONALEESA-3 [J]. J Clin Oncol, 2018, 36(24): 2465-2472.
[11]
Slamon DJ, Neven P, Chia S, et al. Overall survival (OS) results of the phase Ⅲ MONALEESA-3 trial of postmenopausal patients (pts) with hormone receptor-positive (HR plus), human epidermal growth factor 2-negative (HER2-) advanced breast cancer (ABC) treated with fulvestrant (FUL) (+) ribociclib (RIB) [J]. Ann Oncol, 2019, 30(5): 856-857.
[12]
Albanell J, Martínez MT, Ramos M et al. Randomized phase Ⅱ study of fulvestrant plus palbociclib or placebo in endocrine-sensitive, hormone receptor-positive/HER2-advanced breast cancer: GEICAM/2014-12 (FLIPPER) [J]. Eur J Cancer, 2022, 161: 26-37.
[13]
Llombart-Cussac A, Pérez-García JM, Bellet M, et al. Fulvestrant-palbociclib vs letrozole-palbociclib as initial therapy for endocrine-sensitive, hormone receptor-positive, ERBB2-negative advanced breast cancer: a randomized clinical trial [J]. JAMA Oncol, 2021, 7(12): 1791-1799.
[14]
Zhang J, Wang Q, Wang Q, et al. Mechanisms of resistance to estrogen receptor modulators in ER+/HER2-advanced breast cancer [J]. Cell Mol Life Sci, 2020, 77(4): 559-572.
[15]
Presti D, Quaquarini E. The PI3K/AKT/mTOR and CDK4/6 pathways in endocrine resistant HR+/HER2-metastatic breast cancer: biological mechanisms and new treatments [J]. Cancers (Basel), 2019, 11(9): 1242.
[16]
Nunnery SE, Mayer IA. Targeting the PI3K/AKT/mTOR pathway in hormone-positive breast cancer [J]. Drugs, 2020, 80(16): 1685-1697.
[17]
Miller TW, Rexer BN, Garrett JT, et al. Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer [J]. Breast Cancer Res, 2011, 13(6): 224.
[18]
Andre F, Ciruelos E, Rubovszky G, et al. Alpelisib for PIK3CA-mutated, hormone receptor-positive advanced breast cancer [J]. N Engl J Med, 2019, 380(20): 1929-1940.
[19]
Andre F, Ciruelos EM, Rubovszky G, et al. Alpelisib (ALP) 1 fulvestrant (FUL) for advanced breast cancer (ABC): Results of the phase Ⅲ SOLAR-1 trial [J]. Ann Oncol, 2018, 29(8): 709.
[20]
Juric D, Loibl S, Andre F, et al. Alpelisib (ALP) with fulvestrant (FUL) in patients (pts) with PIK3CA-mutated hormone receptor-positive (HR plus), human epidermal growth factor receptor-2-negative (HER2-) advanced breast cancer (ABC): Primary or secondary resistance to prior endocrine therapy (ET) in the SOLAR-1 trial [J]. J Clin Oncol, 2019, 37(15): 1038.
[21]
Andre F, Ciruelos EM, Juric D, et al. Overall survival (OS) results from SOLAR-1, a phase Ⅲ study of alpelisib (ALP) plus fulvestrant (FUL) for hormone receptor-positive (HR plus), human epidermal growth factor receptor 2-negative (HER2e) advanced breast cancer (ABC) [J]. Ann Oncol, 2020, 31(4): S1150-1151.
[22]
Rugo HS, Lerebours F, Ciruelos E, et al. Alpelisib plus fulvestrant in PIK3CA-mutated, hormone receptor-positive advanced breast cancer after a CDK4/6 inhibitor (BYLieve): one cohort of a phase 2, multicentre, open-label, non-comparative study [J]. Lancet Oncol, 2021, 22(4): 489-498.
[23]
Rugo HS, Lerebours F, Ciruelos E, et al. PIK3CA-mutated (mut) hormone receptor-positive (HR plus), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC) previously treated with cyclin-dependent kinase 4/6 inhibitor (CDKi) plus aromatase inhibitor (AI): BYLieve study results [J]. J Clin Oncol, 2020, 38(15): 1006.
[24]
Rugo HS, Lerebours F, Juric D, et al. Alpelisib + letrozole in patients with PIK3CA-mutated, hormone-receptor positive (HR+), human epidermal growth factor receptor-2-negative (HER2-) advanced breast cancer (ABC) previously treated with a cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) + fulvestrant: BYLieve study results [J]. Cancer Res, 2021, 81(4_Suppl): PD2-07.
[25]
Bardia A, Hurvitz SA, Demichele A, et al. Phase Ⅰ/Ⅱ trial of exemestane, ribociclib, and everolimus in women with HR/HER2 advanced breast ccancer after progression on CDK4/6 inhibitors (TRINITI-1) [J]. Clin Cancer Res, 2021, 27(15): 4177-4185.
[26]
Wouters BJ, Delwel R. Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia [J]. Blood, 2016, 127(1): 42-52.
[27]
Sermer D, Pasqualucci L, Wendel HG, et al. Emerging epigenetic-modulating therapies in lymphoma [J]. Nat Rev Clin Oncol, 2019, 16(8): 494-507.
[28]
Jiang ZF, Li W, Hu XC, et al. Tucidinostat plus exemestane for postmenopausal patients with advanced, hormone receptor-positive breast cancer (ACE): a randomised, double-blind, placebo-controlled, phase 3 trial [J]. Lancet Oncol, 2019, 20(6): 806-815.
[29]
O’Shaughnessy J, Schwartzberg L, Piccart M, et al. Results from CONTESSA: a phase 3 study of tesetaxel plus a reduced dose of capecitabine versus capecitabine alone in patients with HER2-,hormone receptor + (HR+) metastatic breast cancer (MBC) who have previously received a taxane [J]. Cancer Res, 2021, 81(4_Suppl): GS4-01.
[1] 郏亚平, 曾书娥. 含鳞状细胞癌成分的乳腺化生性癌的超声与病理特征分析[J]. 中华医学超声杂志(电子版), 2023, 20(08): 844-848.
[2] 唐玮, 何融泉, 黄素宁. 深度学习在乳腺癌影像诊疗和预后预测中的应用[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 323-328.
[3] 康夏, 田浩, 钱进, 高源, 缪洪明, 齐晓伟. 骨织素抑制破骨细胞分化改善肿瘤骨转移中骨溶解的机制研究[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 329-339.
[4] 衣晓丽, 胡沙沙, 张彦. HER-2低表达对乳腺癌新辅助治疗疗效及预后的影响[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 340-346.
[5] 施杰, 李云涛, 高海燕. 腋窝淋巴结阳性Luminal A型乳腺癌患者新辅助与辅助化疗的预后及影响因素分析[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 353-361.
[6] 伍秋苑, 陈佩贤, 邓裕华, 何添成, 周丹. 肠道微生物在乳腺癌中的研究进展[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 362-365.
[7] 谭巧, 苏小涵, 侯令密, 黎君彦, 邓世山. 乳腺髓样癌的诊治进展[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 366-368.
[8] 周婉丽, 钱铮, 李喆. 槐耳在乳腺癌免疫治疗中的研究进展[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 369-371.
[9] 熊倩, 罗凤. 乳腺癌患者术后康复现状与对策的研究进展[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 372-374.
[10] 杨小菁, 姜瑞瑞, 石玉香, 王静静, 李长天. 乳腺孤立性纤维性肿瘤一例[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 375-377.
[11] 冯雪园, 韩萌萌, 马宁. 乳腺原发上皮样血管内皮瘤一例[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 378-380.
[12] 晏晴艳, 雍晓梅, 罗洪, 杜敏. 成都地区老年转移性乳腺癌的预后及生存因素研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 636-638.
[13] 李智铭, 郭晨明, 庄晓晨, 候雪琴, 高军喜. 早期乳腺癌超声造影定性及定量指标的对比研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 639-643.
[14] 屈洪波, 朱芳, 徐喆, 武楠, 何建怀, 王先明. 经肌间入路行锁骨下淋巴结清扫在局部晚期乳腺癌中的应用[J]. 中华普外科手术学杂志(电子版), 2023, 17(05): 510-513.
[15] 陈珊, 胡智强, 张月明, 唐定, 黎蒙, 赵帅. Orai1、Orai3在乳腺癌组织中的表达及与病理学指标的相关性分析[J]. 中华普外科手术学杂志(电子版), 2023, 17(05): 514-517.
阅读次数
全文


摘要