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中华乳腺病杂志(电子版) ›› 2022, Vol. 16 ›› Issue (06) : 365 -369. doi: 10.3877/cma.j.issn.1674-0807.2022.06.006

综述

激素受体阳性/人表皮生长因子受体2阴性晚期乳腺癌的治疗进展
张蓝心1, 高天琦1, 徐岭植1, 李曼1,()   
  1. 1. 116023 大连医科大学附属第二医院肿瘤内科
  • 收稿日期:2021-02-08 出版日期:2022-12-01
  • 通信作者: 李曼
  • 基金资助:
    国家自然科学基金项目(81872156); 辽宁省自然科学基金项目(2019-MS-096); 大连市科技创新基金项目(2019J13SN87)

Treatment of hormone receptor-positive / human epidermal growth factor receptor-2-negative advanced breast cancer

Lanxin Zhang1, Tianqi Gao1, Lingzhi Xu1   

  • Received:2021-02-08 Published:2022-12-01
引用本文:

张蓝心, 高天琦, 徐岭植, 李曼. 激素受体阳性/人表皮生长因子受体2阴性晚期乳腺癌的治疗进展[J/OL]. 中华乳腺病杂志(电子版), 2022, 16(06): 365-369.

Lanxin Zhang, Tianqi Gao, Lingzhi Xu. Treatment of hormone receptor-positive / human epidermal growth factor receptor-2-negative advanced breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2022, 16(06): 365-369.

激素受体(HR)阳性/人表皮生长因子受体2(HER-2)阴性是常见的乳腺癌分子亚型。内分泌治疗作为其重要的治疗手段,已经被各大指南和专家共识推荐为一线策略(内脏危象或疾病快速进展除外)。随着细胞周期蛋白依赖激酶4/6抑制剂、组蛋白去乙酰化酶抑制剂、蛋白激酶B/哺乳动物雷帕霉素靶蛋白通路抑制剂等靶向药物的应用,HR阳性/HER-2阴性晚期乳腺癌进入了靶向治疗时代,临床医师逐步探索其标准化、精准化的治疗模式和深入。笔者从一线治疗策略、内分泌敏感患者中细胞周期依赖性激酶(CDK)4/6抑制剂的联合药物及病情进展后的解救治疗方案3个方面,总结了有关HR阳性/HER-2阴性晚期乳腺癌治疗的相关研究进展,供同行参考。

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