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中华乳腺病杂志(电子版) ›› 2022, Vol. 16 ›› Issue (02) : 102 -105. doi: 10.3877/cma.j.issn.1674-0807.2022.02.006

综述

乳腺外科医师基础研究方向与临床转化热点思考
林群1, 罗晴1, 林婉宜1, 张爱玲2,(), 龚畅3,()   
  1. 1. 510120 广州,中山大学孙逸仙纪念医院乳腺肿瘤中心;510120 广州,广东省恶性肿瘤表观遗传与基因调控重点实验室
    2. 523018 东莞市人民医院乳腺科
    3. 510120 广州,中山大学孙逸仙纪念医院乳腺肿瘤中心;510120 广州,广东省恶性肿瘤表观遗传与基因调控重点实验室;510005 广州再生医学与健康实验室
  • 收稿日期:2020-04-09 出版日期:2022-04-01
  • 通信作者: 张爱玲, 龚畅
  • 基金资助:
    科技部国家重大研发计划资助项目(2017YFC1309103、2017YFC1309104); 国家自然科学基金面上项目(81672594、81772836、81872139); 广州再生医学与健康广东省实验室临床创新研究资助项目(2018GZR0201004); 中山大学孙逸仙纪念医院逸仙临床研究培育项目(SYS-C-201805)

Basic research direction and clinical transformation of breast surgeons

Qun Lin1, Qing Luo1, Wanyi Lin1   

  • Received:2020-04-09 Published:2022-04-01
引用本文:

林群, 罗晴, 林婉宜, 张爱玲, 龚畅. 乳腺外科医师基础研究方向与临床转化热点思考[J]. 中华乳腺病杂志(电子版), 2022, 16(02): 102-105.

Qun Lin, Qing Luo, Wanyi Lin. Basic research direction and clinical transformation of breast surgeons[J]. Chinese Journal of Breast Disease(Electronic Edition), 2022, 16(02): 102-105.

乳腺癌外科治疗理念已由"最大的可耐受治疗"转变为"最小的有效治疗",局部治疗和全身治疗理念的不断融合、冲击,需要乳腺外科医师越来越多地从系统治疗的角度,结合基础研究全方位地思考和探索未来治疗方法的定位和发展。已有基础研究转化为临床应用,并改变临床实践的例子。近年随着分子生物学和多基因组学的迅猛发展,给乳腺外科医师带来了新一轮的冲击和挑战。笔者选取目前乳腺癌外科领域研究的4个热点问题,包括保留乳房手术与抗肿瘤免疫、新辅助治疗后外科手术与全身系统治疗、原发性Ⅳ期乳腺癌患者原发灶切除后获益人群的探索、BRCA基因突变与乳房预防性切除,来思考和探索乳腺外科医师的基础研究和临床转化的方向。

[1]
Sung H, Ferlay J, Siegel R, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 71(3), 209-249.
[2]
Fisher B.From Halsted to prevention and beyond: advances in the management of breast cancer during the twentieth century[J].Eur J Cancer199935(14):1963-1973.
[3]
van Maaren MCde Munck Lde Bock GH, et al.10 year survival after breast-conserving surgery plus radiotherapy compared with mastectomy in early breast cancer in the Netherlands: a population-based study[J].Lancet Oncol201617(8):1158-1170.
[4]
Chen KPan ZZhu L, et al.Comparison of breast-conserving surgery and mastectomy in early breast cancer using observational data revisited: a propensity score-matched analysis[J].Sci China Life Sci201861(12):1528-1536.
[5]
Bernstein MBKrishnan SHodge JW, et al.Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?[J].Nat Rev Clin201613(8):516-524.
[6]
Vanpouille-Box CFormenti SCDemaria S.Toward precision radiotherapy for use with immune checkpoint blockers[J].Clin Cancer Res201824(2):259-265.
[7]
Sherene LSteven D. Pilot study of stereotactic ablation for oligometastatic breast neoplasia in combination with the anti-PD-1 antibody MK-3475[EB/OL]. [2021-04-29].

URL    
[8]
Steven C. Study of PD1 blockade by pembrolizumab with stereotactic body radiotherapy in advanced solid tumors[EB/OL].[2021-04-29].

URL    
[9]
Christopher B. Study to assess the efficacy of pembrolizumab plus radiotherapy in metastatic triple negative breast cancer patients[EB/OL].[2021-04-29].

URL    
[10]
Sara T. Phase Ⅱ pembrolizumab + palliative radiotherapy in BC[EB/OL]. [2021-04-29].

URL    
[11]
Adams SGatti-Mays MEKalinsky K,et al.Current landscape of immunotherapy in breast cancer: a review[J].JAMA Oncol20195(8):1205-1214.
[12]
Barkal AABrewer REMarkovic M,et al.CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy[J].Nature2019572(7769):392-396.
[13]
Garner Hde Visser KE.Immune crosstalk in cancer progression and metastatic spread: a complex conversation[J].Nat Rev Immunol202020(8):1-15.
[14]
Derks MGM, van de Velde CJH.Neoadjuvant chemotherapy in breast cancer: more than just downsizing[J].Lancet Oncol201819(1):2-3.
[15]
Pusztai LFoldi JDhawan A,et al.Changing frameworks in treatment sequencing of triple-negative and HER2-positive, early-stage breast cancers[J].Lancet Oncol201920(7):e390-e396.
[16]
Gianni LEiermann WSemiglazov V, et al.Neoadjuvant and adjuvant trastuzumab in patients with HER2-positive locally advanced breast cancer (NOAH): follow-up of a randomised controlled superiority trial with a parallel HER2-negative cohort[J].Lancet Oncol201415(6):640-647.
[17]
Schmid PCortes JPusztai L,et al.Pembrolizumab for early triple-negative breast cancer[J].N Engl J Med2020382(9):810-821.
[18]
Diver EDorigo O, Berek J.ASCO 2019 meeting review[EB/OL].[2021-01-15].

URL    
[19]
Heil J, Pfob A, Sinn H, et al. Diagnosing pathologic complete response in the breast after neoadjuvant systemic treatment of breast cancer patients by minimal invasive biopsy: Oral presentation at the San Antonio Breast Cancer Symposium on Friday, December 13, 2019, program number GS5-03[J]. Ann Surg2022275(3):576-581.
[20]
Tan W, Liang G, Xie X, et al.Incorporating microRNA into molecular phenotypes of circulating tumor cells enhances the prognostic accuracy for patients with metastatic breast cancer[J].Oncologist201924(11):e1044-e1054.
[21]
Liang GLing YMehrpour M, et al.Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression[J].Mol Cancer202019(1):65.
[22]
Liu ZZhou YLiang G, et al.Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p[J].Cell Death Dis201910(2):55.
[23]
Li SLai HLiu J, et al.Circulating tumor DNA predicts the response and prognosis in patients with early breast cancer receiving neoadjuvant chemotherapy[J].JCO Precis Oncol20204:PO.19.00292.
[24]
魏兵,杨文涛.乳腺癌新辅助治疗的病理诊断专家共识(2020版)[J].中华病理学杂志2020(4):296-304.
[25]
Masuda NLee SJOhtani S,et al.Adjuvant capecitabine for breast cancer after preoperative chemotherapy[J].N Engl J Med2017376(22):2147-2159.
[26]
von Minckwitz GHuang CSMano MS, et al.Trastuzumab emtansine for residual invasive HER-2-positive breast cancer[J].N Engl J Med2019380(7):617-628.
[27]
Gong CTan WChen K, et al.Prognostic value of a BCSC-associated microRNA signature in hormone receptor-positive HER-2-negative breast cancer[J].EBioMedicine201611:199-209.
[28]
Badwe RHawaldar RNair N, et al.Locoregional treatment versus no treatment of the primary tumour in metastatic breast cancer: an open-label randomised controlled trial[J].Lancet Oncol201516(13):1380-1388.
[29]
Soran AOzmen VOzbas S, et al.Randomized trial comparing resection of primary tumor with no surgery in stage iv breast cancer at presentation: Protocol MF07-01[J].Ann Surg Oncol201825(11):3141-3149.
[30]
Modi SSaura CYamashita T, et al.Trastuzumab deruxtecan in previously treated her2-positive breast cancer[J].N Engl J Med2020382(7):610-621.
[31]
Domchek SM.Risk-reducing mastectomy in BRCA1 and BRCA2 mutation carriers: a complex discussion[J].JAMA2019321(1):27.
[32]
Ramaswami RMorrow MJagsi R.Contralateral prophylactic mastectomy[J].N Engl J Med2017377(13):1288-1291.
[33]
Wong SMFreedman RASagara Y, et al.Growing use of contralateral prophylactic mastectomy despite no improvement in long-term survival for invasive breast cancer[J].Ann Surg2017265(3):581-589.
[34]
Tung NMBoughey JCPierce LJ, et al.Management of hereditary breast cancer: American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Guideline[J].J Clin Oncol202038(18):2080-2106.
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