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中华乳腺病杂志(电子版) ›› 2022, Vol. 16 ›› Issue (02) : 102 -105. doi: 10.3877/cma.j.issn.1674-0807.2022.02.006

综述

乳腺外科医师基础研究方向与临床转化热点思考
林群1, 罗晴1, 林婉宜1, 张爱玲2,(), 龚畅3,()   
  1. 1. 510120 广州,中山大学孙逸仙纪念医院乳腺肿瘤中心;510120 广州,广东省恶性肿瘤表观遗传与基因调控重点实验室
    2. 523018 东莞市人民医院乳腺科
    3. 510120 广州,中山大学孙逸仙纪念医院乳腺肿瘤中心;510120 广州,广东省恶性肿瘤表观遗传与基因调控重点实验室;510005 广州再生医学与健康实验室
  • 收稿日期:2020-04-09 出版日期:2022-04-01
  • 通信作者: 张爱玲, 龚畅
  • 基金资助:
    科技部国家重大研发计划资助项目(2017YFC1309103、2017YFC1309104); 国家自然科学基金面上项目(81672594、81772836、81872139); 广州再生医学与健康广东省实验室临床创新研究资助项目(2018GZR0201004); 中山大学孙逸仙纪念医院逸仙临床研究培育项目(SYS-C-201805)

Basic research direction and clinical transformation of breast surgeons

Qun Lin1, Qing Luo1, Wanyi Lin1   

  • Received:2020-04-09 Published:2022-04-01
引用本文:

林群, 罗晴, 林婉宜, 张爱玲, 龚畅. 乳腺外科医师基础研究方向与临床转化热点思考[J/OL]. 中华乳腺病杂志(电子版), 2022, 16(02): 102-105.

Qun Lin, Qing Luo, Wanyi Lin. Basic research direction and clinical transformation of breast surgeons[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2022, 16(02): 102-105.

乳腺癌外科治疗理念已由"最大的可耐受治疗"转变为"最小的有效治疗",局部治疗和全身治疗理念的不断融合、冲击,需要乳腺外科医师越来越多地从系统治疗的角度,结合基础研究全方位地思考和探索未来治疗方法的定位和发展。已有基础研究转化为临床应用,并改变临床实践的例子。近年随着分子生物学和多基因组学的迅猛发展,给乳腺外科医师带来了新一轮的冲击和挑战。笔者选取目前乳腺癌外科领域研究的4个热点问题,包括保留乳房手术与抗肿瘤免疫、新辅助治疗后外科手术与全身系统治疗、原发性Ⅳ期乳腺癌患者原发灶切除后获益人群的探索、BRCA基因突变与乳房预防性切除,来思考和探索乳腺外科医师的基础研究和临床转化的方向。

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