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中华乳腺病杂志(电子版) ›› 2020, Vol. 14 ›› Issue (01) : 54 -57. doi: 10.3877/cma.j.issn.1674-0807.2020.01.013

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ABCB1基因多态性对乳腺癌紫杉醇治疗反应的影响
郝帅1, 田武国1, 高博1, 何渝军1, 罗东林1,()   
  1. 1. 400042 重庆,陆军军医大学第三附属医院乳腺甲状腺外科
  • 收稿日期:2018-06-21 出版日期:2020-02-01
  • 通信作者: 罗东林

Polymorphism of ABCB1 gene on breast cancer patients’ response to paclitaxel

Shuai Hao1, Wuguo Tian1, Bo Gao1   

  • Received:2018-06-21 Published:2020-02-01
引用本文:

郝帅, 田武国, 高博, 何渝军, 罗东林. ABCB1基因多态性对乳腺癌紫杉醇治疗反应的影响[J]. 中华乳腺病杂志(电子版), 2020, 14(01): 54-57.

Shuai Hao, Wuguo Tian, Bo Gao. Polymorphism of ABCB1 gene on breast cancer patients’ response to paclitaxel[J]. Chinese Journal of Breast Disease(Electronic Edition), 2020, 14(01): 54-57.

化学治疗是乳腺癌综合治疗的重要组成部分,其中以紫杉醇类药物为基础的化疗方案已被广泛应用,能有效降低复发率并延长患者生存期。但部分患者对紫杉醇类药物反应不佳,紫杉醇类药物诱发的不良反应不仅影响患者的生活质量,而且会导致化疗的延误,甚至中止,均会影响治疗效果。ABCB1基因编码的P-糖蛋白是紫杉醇类药物体内转运途径的关键酶。大量研究表明ABCB1基因单核苷酸多态性可能会改变P-糖蛋白的结构,从而影响其功能活性,继而对紫杉醇类药物清除和细胞内外转运过程产生影响,产生个体化差异的化疗反应。这不仅与紫杉醇类诱导的不良反应相关,并且能够影响患者的远期生存。因此,ABCB1基因多态性具有预测紫杉醇类药物化疗效果和不良反应的潜在价值,对于个体化的药物应用具有重要意义。

表1 ABCB1基因单核苷酸多态性与紫杉醇为基础的化疗不良反应的相关性
表2 ABCB1基因单核苷酸多态性与紫杉醇为基础的化疗结局的相关性
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