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中华乳腺病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (02) : 120 -122. doi: 10.3877/cma.j.issn.1674-0807.2018.02.012

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zeste基因增强子同源物2在乳腺癌中的研究现状
孙典典1, 李靖若1,(), 张临风1, 孙丹丹1   
  1. 1. 450000 郑州大学第一附属医院乳腺外二科
  • 收稿日期:2017-02-14 出版日期:2018-04-01
  • 通信作者: 李靖若

Research status of zeste gene enhancer homolog 2 in breast cancer

Diandian Sun1, Jingruo Li1(), Linfeng Zhang1   

  • Received:2017-02-14 Published:2018-04-01
  • Corresponding author: Jingruo Li
引用本文:

孙典典, 李靖若, 张临风, 孙丹丹. zeste基因增强子同源物2在乳腺癌中的研究现状[J]. 中华乳腺病杂志(电子版), 2018, 12(02): 120-122.

Diandian Sun, Jingruo Li, Linfeng Zhang. Research status of zeste gene enhancer homolog 2 in breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2018, 12(02): 120-122.

zeste基因增强子同源物2(EZH2)是果蝇zeste基因增强子[E(z)]的人类同源物组蛋白甲基化的重要工具酶,也是多梳基因家族PcG(polycomb group)的核心成员。EZH2参与多梳蛋白复合体2的形成,促使相应组蛋白甲基化,从表观遗传学的角度介导相应靶基因沉默,在肿瘤的发生、发展过程中发挥着重要作用。其高表达与多种恶性肿瘤的发生、发展和极差的预后密切相关。近年来,越来越多的学者对EZH2的致癌机制进行了深入研究,为乳腺癌转移的检测、预后评估及治疗提供了全新的思路。笔者就EZH2表达情况及其与乳腺癌发生、发展、转移及预后之间的关系作一综述,以便临床医师更好地认识这一新的肿瘤标志物。

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