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中华乳腺病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (02) : 69 -72. doi: 10.3877/cma.j.issn.1674-0807.2018.02.002

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激素受体阳性晚期转移性乳腺癌的内分泌治疗
高德宗1,()   
  1. 1. 250033 济南,山东大学第二医院乳腺科
  • 收稿日期:2016-08-19 出版日期:2018-04-01
  • 通信作者: 高德宗
  • 基金资助:
    山东省自然科学基金资助项目(2015ZRE27471)

Endocrine therapy for hormone receptor-positive advanced metastatic breast cancer

Dezong Gao1,()   

  1. 1. Department of Breast Surgery, Second Hospital of Shandong University, Jinan 250033, China
  • Received:2016-08-19 Published:2018-04-01
  • Corresponding author: Dezong Gao
  • About author:
    Corresponding author: Gao Dezong, Email:
引用本文:

高德宗. 激素受体阳性晚期转移性乳腺癌的内分泌治疗[J/OL]. 中华乳腺病杂志(电子版), 2018, 12(02): 69-72.

Dezong Gao. Endocrine therapy for hormone receptor-positive advanced metastatic breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2018, 12(02): 69-72.

对于晚期转移性乳腺癌患者,临床治疗的目的是减轻症状、改善生活质量及延长患者生存时间。由于内分泌治疗不良反应小、疗效好,是激素受体阳性没有内脏危象的晚期乳腺癌患者的优先选择。内分泌治疗可能最终会导致耐药,如何延缓耐药,推迟化疗从而减轻患者痛苦是目前临床研究的热点。笔者总结了绝经前、后激素受体阳性晚期转移性乳腺癌患者内分泌治疗相关研究的最新进展以及其与小分子靶向药物联合应用的效果,希望为广大乳腺外科医师提供参考。

For the patients with advanced metastatic breast cancer, clinical treatment aims to relieve the symptoms, improve quality of life and prolong patients' survival. Endocrine therapy has mild adverse reactions and good efficacy, regarded as the first choice of hormone receptor-positive advanced breast cancer patients without visceral crisis. Endocrine therapy may eventually lead to drug resistance. How to postpone the drug resistance, put off the chemotherapy and reduce the pain is currently the hotspot of clinical research. In this paper, we summarized the latest research advancement in endocrine therapy and its combination with small molecule targeted drugs for pre- and post-menopausal hormone receptor-positive advanced metastatic breast cancer, in order to provide a reference for breast surgeons.

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