目的

探讨乳腺针吸细胞学(FNAC)检查对乳腺肿瘤诊断的准确性及应用价值。

方法

对1193例乳腺疾病患者进行FNAC 检查,按照FNAC 诊断标准进行分级诊断;并将其中267例患者的组织病理学检查结果与FNAC 检查结果进行对比分析。FNAC 分级诊断结果与患者的年龄、肿瘤部位及大小之间的相关性分析采用χ² 检验。

结果

1193 例患者中,FNAC 诊断:I 级886 例(74.3%);II 级228例(19.1%);III级44例(3.6%);IV 级35例(2.9%)。乳腺FNAC阳性检出率(III级+IV 级)与患者的年龄、肿瘤部位及大小无显著相关性。FNAC 检查对乳腺恶性肿瘤诊断的敏感性为92.9%(79/85),特异性为100%(182/182);阳性似然比趋向无穷大,阴性似然比为0.07,Youden指数为0.93;假阴性率为7.0%(6/85),无一例假阳性。

结论

乳腺FNAC诊断乳腺恶性肿瘤的准确性高,对临床诊断、治疗有一定指导意义。

Objective

To st udy t he accuracy and clinical application val ue of fine needle aspiration cytol ogy(FNAC)in diagnosing breast t u mors.

Methods

FNAC was perf or med on 1193 cases with breast lesions,and 267 of t he m were subjected to histopat hol ogy diagnosis as well.The FNAC and histopathological diagnosis results were co mpared and anal yzed.The correlation bet ween FNAC results and age of patients,original region and size of tu mor was analyzed by chisquare test.

Results

Of the 1193 fine needle aspiration samples,886(74.3%)were diagnosed as grade I,228(19.1%)as Grade II,44(3.6%)as Grade III,and 35(2.9%)as grade IV.FNAC positive proportion(Grade III+Grade IV)didn't correlate with the age of patients,original region and size of tumor.Among them,267 cases were studied with histopathology as well.The sensitivity and the specificity of malignant tumor were 92.9% (79/85)and 100% (182/182),respectively.The positive likelihood ratio was infinite,and the negative likelihood ratio was 0.07,the Youden index was 0.93,the false negative rate were 7.0%(6/85),no false positive diagnosis was found.

Conclusions

FNAC has high accu-racy in diagnosing breast tumors,and is of clinical significance in guiding diagnosis and treatment.