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中华乳腺病杂志(电子版) ›› 2026, Vol. 20 ›› Issue (05) : 318 -322. doi: 10.3877/cma.j.issn.1674-0807.2026.05.009

综述

不同分子分型乳腺癌类器官模型的构建与优化
罗怡欣, 王泳翕, 谢晓云, 黎珂睿, 李杰, 张哲, 陈卓, 王芳†()   
  1. 450052 郑州,郑州大学第一附属医院乳腺外科
  • 收稿日期:2025-12-08 出版日期:2026-10-01
  • 通信作者: 王芳

Construction and optimization of organoid models for different molecular subtypes of breast cancer

Yixin Luo, Yongxi Wang, Xiaoyun Xie   

  • Received:2025-12-08 Published:2026-10-01
引用本文:

罗怡欣, 王泳翕, 谢晓云, 黎珂睿, 李杰, 张哲, 陈卓, 王芳. 不同分子分型乳腺癌类器官模型的构建与优化[J/OL]. 中华乳腺病杂志(电子版), 2026, 20(05): 318-322.

Yixin Luo, Yongxi Wang, Xiaoyun Xie. Construction and optimization of organoid models for different molecular subtypes of breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2026, 20(05): 318-322.

乳腺癌不同分子分型在激素依赖、HER-2信号、干性维持和微环境依赖方面存在差异,这些差异会影响类器官的形成、扩增和表型稳定。患者来源乳腺癌类器官可保留部分来源肿瘤的组织结构、受体状态和药物反应,已被用于机制研究、药物筛选和治疗反应评估。本文围绕Luminal型、HER-2阳性型和三阴性乳腺癌的培养需求,归纳不同分子分型乳腺癌类器官的建模难点、质控指标和优化方向,并分析样本代表性、微环境缺失和标准化不足对后续应用的影响。

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