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中华乳腺病杂志(电子版) ›› 2025, Vol. 19 ›› Issue (02) : 70 -75. doi: 10.3877/cma.j.issn.1674-0807.2025.02.002

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乳腺癌HER-2低表达及超低表达临床研究进展
李金泽1, 彭雅琪2, 刘月平1, 马力3,()   
  1. 1. 050035 石家庄,河北医科大学第四医院病理科
    2. 050017 石家庄,河北医科大学基础医学院临床医学系
    3. 050035 石家庄,河北医科大学第四医院乳腺中心
  • 收稿日期:2024-10-22 出版日期:2025-04-01
  • 通信作者: 马力

Clinical insights on HER-2-low and HER-2-ultralow in breast cancer

Jinze Li1, Yaqi Peng2, Yueping Liu1, Li Ma3,()   

  1. 1. Department of Pathology,Fourth Hospital of Hebei Medical University, Shijiazhuang 050035, China
    2. Department of Clinical Medicine, College of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China
    3. Breast Disease Center, Fourth Hospital of Hebei Medical University, Shijiazhuang 050035, China
  • Received:2024-10-22 Published:2025-04-01
  • Corresponding author: Li Ma
引用本文:

李金泽, 彭雅琪, 刘月平, 马力. 乳腺癌HER-2低表达及超低表达临床研究进展[J/OL]. 中华乳腺病杂志(电子版), 2025, 19(02): 70-75.

Jinze Li, Yaqi Peng, Yueping Liu, Li Ma. Clinical insights on HER-2-low and HER-2-ultralow in breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2025, 19(02): 70-75.

乳腺癌治疗的关键在于早期诊断和有效的治疗手段。HER-2在乳腺癌的生物学行为及发病机制中发挥着关键作用。随着新型抗体药物偶联物的问世,打破了传统抗HER-2靶向治疗依赖HER-2受体表达或基因扩增的局面,使得乳腺癌HER-2低表达及超低表达患者不断进入研究序列,成为临床研究的焦点,开启了乳腺癌治疗的新篇章。本文旨在从临床及病理学角度,对乳腺癌HER-2低表达及超低表达检测的必要性、检测手段及影响HER-2低表达及超低表达精准检测的因素等方面展开综述。

The key to successful treatment of breast cancer lies in the prompt diagnosis and effective therapeutic strategies. HER-2 plays a pivotal role in the biological behavior and pathogenesis of breast cancer,exerting significant influence on its progression and development. The development of novel antibody-drug conjugates (ADC) has disrupted the situation where traditional anti-HER-2 targeted therapy relied on receptor expression or gene amplification, bringing HER-2-low and HER-2-ultralow subtypes of breast cancer increasingly into the public view. This has sparked a renewed research focus and inaugurated a new era in the treatment of breast cancer. This article aims to provide a comprehensive review from clinical and pathological perspectives regarding the necessity of detecting HER-2-low and HER-2-ultralow expression in breast cancer,detection methods, as well as the factors influencing the precise detection of HER-2-low and HER-2-ultralow subtypes.

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