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中华乳腺病杂志(电子版) ›› 2024, Vol. 18 ›› Issue (03) : 175 -179. doi: 10.3877/cma.j.issn.1674-0807.2024.03.007

综述

乳酸脱氢酶A在乳腺癌中的作用
刘世佳1, 陶新楠1, 史晋宇1, 吕文豪1, 张亚芬1,()   
  1. 1. 030001 太原,山西医科大学附属第五临床医学院乳腺外科
  • 收稿日期:2022-11-25 出版日期:2024-06-01
  • 通信作者: 张亚芬

Role of lactate dehydrogenase A in breast cancer

Shijia Liu, Xinnan Tao, Jinyu Shi   

  • Received:2022-11-25 Published:2024-06-01
引用本文:

刘世佳, 陶新楠, 史晋宇, 吕文豪, 张亚芬. 乳酸脱氢酶A在乳腺癌中的作用[J]. 中华乳腺病杂志(电子版), 2024, 18(03): 175-179.

Shijia Liu, Xinnan Tao, Jinyu Shi. Role of lactate dehydrogenase A in breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2024, 18(03): 175-179.

乳腺癌是具有高度异质性和复杂性的代谢疾病,主要通过Warburg效应进行细胞代谢重编程。乳酸脱氢酶A是Warburg效应的关键酶,在乳腺癌增殖、迁移、酸性微环境形成、免疫逃逸等方面发挥着关键作用。因此,笔者就乳酸脱氢酶A的结构、位置、功能及其在乳腺癌中的作用机制进行总结,着重讨论其在乳腺癌临床诊断、治疗和预后中的潜在意义,并提出乳酸脱氢酶A可作为抑制乳腺癌增殖和侵袭的新靶点。

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