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中华乳腺病杂志(电子版) ›› 2024, Vol. 18 ›› Issue (02) : 124 -127. doi: 10.3877/cma.j.issn.1674-0807.2024.02.011

综述

SHP基因影响乳腺癌内分泌治疗耐药的研究进展
古娇娇1, 李文涛1,()   
  1. 1. 450000 郑州大学人民医院乳腺外科
  • 收稿日期:2023-01-25 出版日期:2024-04-01
  • 通信作者: 李文涛

Impact of SHP gene on endocrine therapy resistance in breast cancer

Jiaojiao Gu, Wentao Li()   

  • Received:2023-01-25 Published:2024-04-01
  • Corresponding author: Wentao Li
引用本文:

古娇娇, 李文涛. SHP基因影响乳腺癌内分泌治疗耐药的研究进展[J]. 中华乳腺病杂志(电子版), 2024, 18(02): 124-127.

Jiaojiao Gu, Wentao Li. Impact of SHP gene on endocrine therapy resistance in breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2024, 18(02): 124-127.

激素受体(HR)阳性乳腺癌约占乳腺癌的70%,其中30%的HR阳性乳腺癌患者会出现内分泌治疗耐药。逆转HR阳性乳腺癌患者内分泌治疗耐药对改善患者预后和提高患者生存率至关重要。生长因子、细胞周期依赖性蛋白激酶、组蛋白去乙酰酶、雄激素受体和PI3K-AKT-mTOR信号通路等多种因素均可诱导HR阳性乳腺癌患者内分泌治疗耐药。短异质二聚体伴侣(SHP)是一种孤儿核受体,可调控多条受体依赖的信号通路。因此,笔者对SHP在HR阳性乳腺癌患者中的表达情况及相关信号通路进行分析,探讨SHP基因与乳腺癌内分泌治疗耐药的相关性,为逆转内分泌治疗耐药寻找新靶点。

图1 核受体和SHP蛋白结构注:NR为核受体;SHP为短异质二聚体伴侣
图2 FXB促进SHP基因表达后的调控途径注:FXR为胆囊酸X受体;SHP为短异质二聚体伴侣;LRH-1为肝受体同源物-1;HDAC为组蛋白去乙酰化酶;ER为雌激素受体;SREBP-1c为类固醇调节元件结合蛋白-1c
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