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中华乳腺病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (03) : 187 -190. doi: 10.3877/cma.j.issn.1674-0807.2018.03.012

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循环肿瘤细胞及循环肿瘤DNA检测在乳腺癌中的研究进展
戚丽娜1, 郑树1,()   
  1. 1. 310009 杭州,浙江大学肿瘤研究所
  • 收稿日期:2016-12-10 出版日期:2018-06-01
  • 通信作者: 郑树

Detection of circulating tumor cells and circulating tumor DNA in breast cancer

Lina Qi1, Shu Zheng1()   

  • Received:2016-12-10 Published:2018-06-01
  • Corresponding author: Shu Zheng
引用本文:

戚丽娜, 郑树. 循环肿瘤细胞及循环肿瘤DNA检测在乳腺癌中的研究进展[J]. 中华乳腺病杂志(电子版), 2018, 12(03): 187-190.

Lina Qi, Shu Zheng. Detection of circulating tumor cells and circulating tumor DNA in breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2018, 12(03): 187-190.

乳腺癌是中国女性最常见的癌症,其早期检测、个体化治疗及实时疾病监测一直是科研及临床工作者关注的重点。癌症患者血液中循环肿瘤细胞(CTC)和循环肿瘤DNA(ctDNA)的检测微创、简便,易实时获取信息。目前,有关CTC富集鉴定方法多种多样,CTC及ctDNA检测的敏感度和特异度较前有所提高,未来研究面临的最大挑战为肿瘤细胞特异性标志物的开发以及ctDNA临床意义的研究。CTC及ctDNA在基础研究、检测方法、CTC培养、早期肿瘤检测、个体化治疗及临床预后等方面的研究均有开展。笔者对乳腺癌CTC及ctDNA的研究进展作一总结。

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