切换至 "中华医学电子期刊资源库"

中华乳腺病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (02) : 116 -119. doi: 10.3877/cma.j.issn.1674-0807.2018.02.011

所属专题: 文献

讲座

多环芳烃与乳腺癌的相关性
禚英杰1, 余之刚1,()   
  1. 1. 250033 济南,山东大学第二医院乳腺外科
  • 收稿日期:2016-08-19 出版日期:2018-04-01
  • 通信作者: 余之刚

Correlation between polycyclic aromatic hydrocarbons and breast cancer

Yingjie Zhuo1, Zhigang Yu1()   

  • Received:2016-08-19 Published:2018-04-01
  • Corresponding author: Zhigang Yu
引用本文:

禚英杰, 余之刚. 多环芳烃与乳腺癌的相关性[J]. 中华乳腺病杂志(电子版), 2018, 12(02): 116-119.

Yingjie Zhuo, Zhigang Yu. Correlation between polycyclic aromatic hydrocarbons and breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2018, 12(02): 116-119.

随着交通工具及现代工业的发展,多环芳烃(PAHs)在空气中的含量逐步增加。乳腺癌作为一种女性常见的恶性肿瘤,发病率逐年上升。部分病因学研究表明,PAHs等环境污染物与乳腺癌存在一定的相关性。PAHs进入机体后,不仅能被代谢解毒,而且也可经代谢而被活化,形成致癌物质。笔者主要从PAHs的体内代谢、关键酶和代谢产物方面进行文献整理,并对当前PAHs与乳腺癌相关性的研究进行总结,进一步探讨PAHs在乳腺癌发病中的作用,以期为乳腺癌的预防和治疗提供新途径。

[1]
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017[J]. CA Cancer J Clin, 2017, 67(1): 7-30.
[2]
Chen W, Zheng R, Zhang S, et al. Cancer incidence and mortality in China in 2013: an analysis based on urbanization level[J]. Chin J Cancer Res, 2017, 29(1): 1-10.
[3]
Manjanatha MG, Chen JB, Shaddock JG, et al. Molecular analysis of lacI mutations in Rat2 cells exposed to 7, 12-dimethylbenz[a]anthracene: evidence for DNA sequence and DNA strand biases for mutation[J]. Mutat Res, 1996, 372(1): 53-64.
[4]
Tsai WT, Mi HH, Chang YM, et al. Polycyclic aromatic hydrocarbons (PAHs) in bio-crudes from induction-heating pyrolysis of biomass wastes[J]. Bioresour Technol, 2007, 98(5): 1133-1137.
[5]
Farmer PB, Singh R, Kaur B, et al. Molecular epidemiology studies of carcinogenic environmental pollutants. Effects of polycyclic aromatic hydrocarbons (PAHs) in environmental pollution on exogenous and oxidative DNA damage[J]. Mutat Res, 2003, 544(2/3): 397-402.
[6]
Nilsson R, Antic' R, Berni A, et al. Exposure to polycyclic aromatic hydrocarbons in women from Poland, Serbia and Italy--relation between PAH metabolite excretion, DNA damage, diet and genotype (the EU DIEPHY project) [J]. Biomarkers, 2013, 18(2): 165-173.
[7]
Lin Y, Yao Y, Liu S, et al. Role of mammary epithelial and stromal P450 enzymes in the clearance and metabolic activation of 7, 12-dimethylbenz(a)anthracene in mice[J]. Toxicol Lett, 2012, 212(2): 97-105.
[8]
Trombino AF, Near RI, Matulka RA, et al. Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis[J]. Breast Cancer Res Treat, 2000, 63(2): 117-131.
[9]
Henke N, Ferreirós N, Geisslinger G, et al. Loss of HIF-1α in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model[J]. Oncotarget, 2016, 7(18): 25 915-25 929.
[10]
黄燚,刘丹,饶绍琴,等.CYP1A1和CYP1A2基因多态性与汉族女性乳腺癌的关系[J/CD]. 中华乳腺病杂志(电子版),2013,7(5):345-350.
[11]
Farrell G. Effects of disease on expression and regulation of CYPs[J]. Mol Aspects Med, 1999, 20(1/2): 55-70, 137.
[12]
Gallagher EP, Wienkers LC, Stapleton PL, et al. Role of human microsomal and human complementary DNA-expressed cytochromes P4501A2 and P4503A4 in the bioactivation of aflatoxin B1[J]. Cancer Res, 1994, 54(1): 101-108.
[13]
Mu J, Jin F, Wang J, et al. The effects of CYP1A inhibition on alkyl-phenanthrene metabolism and embryotoxicity in marine medaka (Oryzias melastigma)[J]. Environ Sci Pollut Res Int, 2016, 23(11): 11 289-11 297.
[14]
Amrein BA, Bauer P, Duarte F, et al. Expanding the catalytic triad in epoxide hydrolases and related enzymes[J]. ACS Catal, 2015, 5(10): 5702-5713.
[15]
Strickland P, Kang D. Urinary 1-hydroxypyrene and other PAH metabolites as biomarkers of exposure to environmental PAH in air particulate matter [J]. Toxicol Lett, 1999, 108(2/3): 191-199.
[16]
Jongeneelen FJ. Benchmark guideline for urinary 1-hydroxypyrene as biomarker of occupational exposure to polycyclic aromatic hydrocarbons [J]. Ann Occup Hyg, 2001, 45(1): 3-13.
[17]
Shiue I. Are urinary polyaromatic hydrocarbons associated with adult hypertension, heart attack, and cancer? USA NHANES, 2011-2012[J]. Environ Sci Pollut Res Int, 2015, 22(21): 16 962-16 968.
[18]
Wang L, Zhao Y, Liu X, et al. Cancer risk of petrochemical workers exposed to airborne PAHs in industrial Lanzhou City, China[J]. Environ Sci Pollut Res Int, 2015, 22(24): 19 793-19 803.
[19]
Khariwala SS, Carmella SG, Stepanov I, et al. Self-reported tobacco use does not correlate with carcinogen exposure in smokers with head and neck cancer [J]. Laryngoscope, 2015, 125(8): 1844-1848.
[20]
Huc L, Rissel M, Solhaug A, et al. Multiple apoptotic pathways induced by p53-dependent acidification in benzo[a]pyrene-exposed hepatic F258 cells[J]. J Cell Physiol, 2006, 208(3): 527-537.
[21]
Kim SJ, Ko CB, Park C, et al. p38 MAP kinase regulates benzo(a)pyrene-induced apoptosis through the regulation of p53 activation[J]. Arch Biochem Biophys, 2005, 444(2): 121-129.
[22]
Topinka J, Milcova A, Libalova H, et al. Biomarkers of exposure to tobacco smoke and environmental pollutants in mothers and their transplacental transfer to the foetus. Part I: bulky DNA adducts [J]. Mutat Res, 2009, 669(1/2): 13-19.
[23]
Moolenaar-Wirsiy PJ, Wirsiy YG, Urso P. Presence of CD4(+) SP and DP (gammadelta, alphabeta) T-cells expressing BPDE-DNA adducts in progeny of mouse dams exposed to benzo (alpha) pyrene at mid-gestation[J]. J Immunotoxicol, 2007, 4(4): 267-277.
[24]
Okona-Mensah KB, Battershill J, Boobis A, et al. An approach to investigating the importance of high potency polycyclic aromatic hydrocarbons (PAHs) in the induction of lung cancer by air pollution[J]. Food Chem Toxicol, 2005, 43(7): 1103-1116.
[25]
Moorthy B, Chu C, Carlin DJ. Polycyclic aromatic hydrocarbons: from metabolism to lung cancer [J]. Toxicol Sci, 2015, 145(1): 5-15.
[26]
Kasala ER, Bodduluru LN, Barua CC, et al. Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice[J]. Pharmacol Rep, 2016, 68(2): 310-318.
[27]
Das S, Das J, Samadder A, et al. Efficacy of PLGA-loaded apigenin nanoparticles in Benzo[a]pyrene and ultraviolet-B induced skin cancer of mice: mitochondria mediated apoptotic signalling cascades[J]. Food Chem Toxicol, 2013, 62: 670-680.
[28]
Harris KL, Pulliam SR, Okoro E, et al. Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a Polyposis In Rat Coli (PIRC) rat model of colon cancer[J]. Oncotarget, 2016, 7(20): 28 947-28 960.
[29]
Kabátková M, Zapletal O, Tylichová Z, et al. Inhibition of β-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation[J]. Mutagenesis, 2015, 30(4): 565-576.
[30]
Gozal D, Ham SA, Mokhlesi B. Sleep apnea and cancer: analysis of a nationwide population sample[J]. Sleep, 2016, 39(8): 1493-1500.
[31]
Liu X, He Y, Li F, et al. Caspase-3 promotes genetic instability and carcinogenesis [J]. Mol Cell, 2015, 58(2): 284-296.
[32]
Kabel AM, Elkhoely AA. Ameliorative potential of fluoxetine/raloxifene combination on experimentally induced breast cancer[J]. Tissue Cell, 2016, 48(2): 89-95.
[33]
Shaban N, Abdel-Rahman S, Haggag A, et al. Combination between taxol-encapsulated liposomes and eruca sativa seed extract suppresses mammary tumors in female rats induced by 7, 12 dimethylbenz(α)anthracene[J]. Asian Pac J Cancer Prev, 2016, 17(1): 117-123.
[34]
Wang F, Ma Z, Wang F, et al. Establishment of novel rat models for premalignant breast disease[J]. Chin Med J (Engl), 2014, 127(11): 2147-2152.
[35]
Parada H Jr, Steck SE, Cleveland RJ, et al. Genetic polymorphisms of phase I metabolizing enzyme genes, their interaction with lifetime grilled and smoked meat intake, and breast cancer incidence[J]. Ann Epidemiol, 2017, 27(3): 208-214.
[36]
Parikh PV, Wei Y. PAHs and PM2.5 emissions and female breast cancer incidence in metro Atlanta and rural Georgia[J]. Int J Environ Health Res, 2016, 26(4): 458-466.
[37]
Pulkrabova J, Stupak M, Svarcova A, et al. Relationship between atmospheric pollution in the residential area and concentrations of polycyclic aromatic hydrocarbons (PAHs) in human breast milk[J]. Sci Total Environ, 2016, 562: 640-647.
[38]
Niehoff N, White AJ, McCullough LE, et al. Polycyclic aromatic hydrocarbons and postmenopausal breast cancer: An evaluation of effect measure modification by body mass index and weight change[J]. Environ Res, 2017, 152: 17-25.
[39]
Fenga C. Occupational exposure and risk of breast cancer[J]. Biomed Rep, 2016, 4(3): 282-292.
[1] 刘婷婷, 林妍冰, 汪珊, 陈幕荣, 唐子鉴, 代东伶, 夏焙. 超声衰减参数成像评价儿童代谢相关脂肪性肝病的价值[J]. 中华医学超声杂志(电子版), 2023, 20(08): 787-794.
[2] 郏亚平, 曾书娥. 含鳞状细胞癌成分的乳腺化生性癌的超声与病理特征分析[J]. 中华医学超声杂志(电子版), 2023, 20(08): 844-848.
[3] 唐玮, 何融泉, 黄素宁. 深度学习在乳腺癌影像诊疗和预后预测中的应用[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 323-328.
[4] 康夏, 田浩, 钱进, 高源, 缪洪明, 齐晓伟. 骨织素抑制破骨细胞分化改善肿瘤骨转移中骨溶解的机制研究[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 329-339.
[5] 衣晓丽, 胡沙沙, 张彦. HER-2低表达对乳腺癌新辅助治疗疗效及预后的影响[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 340-346.
[6] 施杰, 李云涛, 高海燕. 腋窝淋巴结阳性Luminal A型乳腺癌患者新辅助与辅助化疗的预后及影响因素分析[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 353-361.
[7] 伍秋苑, 陈佩贤, 邓裕华, 何添成, 周丹. 肠道微生物在乳腺癌中的研究进展[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 362-365.
[8] 谭巧, 苏小涵, 侯令密, 黎君彦, 邓世山. 乳腺髓样癌的诊治进展[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 366-368.
[9] 周婉丽, 钱铮, 李喆. 槐耳在乳腺癌免疫治疗中的研究进展[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 369-371.
[10] 熊倩, 罗凤. 乳腺癌患者术后康复现状与对策的研究进展[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 372-374.
[11] 杨小菁, 姜瑞瑞, 石玉香, 王静静, 李长天. 乳腺孤立性纤维性肿瘤一例[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 375-377.
[12] 冯雪园, 韩萌萌, 马宁. 乳腺原发上皮样血管内皮瘤一例[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 378-380.
[13] 何吉鑫, 杨燕妮, 王继伟, 李建国, 谢铭. 肠道菌群及肠道代谢产物参与慢性便秘发生机制的研究进展[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 495-499.
[14] 王磊, 李梦, 孙文利, 刘瑞, 王红春, 卢光泽, 赵颖, 郭进艳, 刘红星. 液相色谱质谱法对急性白血病患者血浆代谢组学的特征分析[J]. 中华临床医师杂志(电子版), 2023, 17(08): 850-857.
[15] 张大涯, 陈世锔, 陈润祥, 张晓冬, 李达, 白飞虎. 肠道微生物群对代谢相关脂肪性肝病发展的影响[J]. 中华临床医师杂志(电子版), 2023, 17(07): 828-833.
阅读次数
全文


摘要