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中华乳腺病杂志(电子版) ›› 2017, Vol. 11 ›› Issue (05) : 296 -299. doi: 10.3877/cma.j.issn.1674-0807.2017.05.009

综述

雄激素受体在乳腺癌治疗中的研究进展
杨满1,2, 韦伟2,()   
  1. 1.515000,广东省汕头大学医学院临床医学系
    2.518000,广东省北京大学深圳医院甲状腺乳腺外科
  • 收稿日期:2016-09-07 出版日期:2017-10-01
  • 通信作者: 韦伟
  • 基金资助:
    深圳市科技计划项目资助研究(JCYJ20150403091443284)

Research progress of androgen receptor in breast cancer treatment

Man Yang, Wei Wei()   

  • Received:2016-09-07 Published:2017-10-01
  • Corresponding author: Wei Wei
引用本文:

杨满, 韦伟. 雄激素受体在乳腺癌治疗中的研究进展[J/OL]. 中华乳腺病杂志(电子版), 2017, 11(05): 296-299.

Man Yang, Wei Wei. Research progress of androgen receptor in breast cancer treatment[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2017, 11(05): 296-299.

乳腺癌是一种全身性疾病,内分泌治疗是其十分重要的治疗方式,但内分泌治疗耐药是临床非常棘手的问题。 雄激素受体(AR)属于核受体超家族,在人体多个组织器官中表达并发挥相应作用。 AR 在相当比例的乳腺癌中呈高表达,可能在乳腺癌发生、发展中起重要作用,有望成为乳腺癌内分泌治疗的新靶点;特别是对传统内分泌治疗耐药及AR 阴性的患者,靶向AR 可能是内分泌治疗有效的补充和解救策略。 笔者总结了AR 的作用机制及其在乳腺癌治疗中的研究进展。

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