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中华乳腺病杂志(电子版) ›› 2017, Vol. 11 ›› Issue (05) : 292 -295. doi: 10.3877/cma.j.issn.1674-0807.2017.05.008

综述

肿瘤特异性CD8+ T 细胞在三阴性乳腺癌免疫治疗中的应用
王梦川1, 吴爱国1,()   
  1. 1.510282 广州,南方医科大学珠江医院普外科
  • 收稿日期:2017-05-20 出版日期:2017-10-01
  • 通信作者: 吴爱国
  • 基金资助:
    南方医科大学科研启动计划(PY2014N062)

Application of tumor-specific CD8+ T cells in immunotherapy for triple-negative breast cancer

Mengchuan Wang, Aiguo Wu()   

  • Received:2017-05-20 Published:2017-10-01
  • Corresponding author: Aiguo Wu
引用本文:

王梦川, 吴爱国. 肿瘤特异性CD8+ T 细胞在三阴性乳腺癌免疫治疗中的应用[J/OL]. 中华乳腺病杂志(电子版), 2017, 11(05): 292-295.

Mengchuan Wang, Aiguo Wu. Application of tumor-specific CD8+ T cells in immunotherapy for triple-negative breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2017, 11(05): 292-295.

三阴性乳腺癌(TNBC)是ER、PR、HER-2 表达均为阴性的一类乳腺癌,临床上常规的治疗手段包括手术、放射治疗及化疗。 肿瘤的免疫治疗是目前的研究热点之一,其中起重要作用的是肿瘤特异性CD8+ T 细胞。 在基础研究方面,CD8+ T 细胞在TNBC 的过继性免疫治疗和肿瘤疫苗领域均有所应用。 在临床研究方面,肿瘤浸润CD8+ T 细胞与TNBC 患者的预后相关,并且,目前已开展的程序性细胞死亡蛋白1(PD-1)/程序性细胞死亡蛋白1 配体(PD-L1)抑制剂亦与肿瘤特异性CD8+ T 细胞的活化调控机制有关。 因此,笔者就肿瘤特异性CD8+ T 细胞在三阴性乳腺癌免疫治疗中的应用进行简要的综述。

表1 近年关于肿瘤浸润CD8+T 细胞与三阴性乳腺癌患者预后的临床研究
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