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中华乳腺病杂志(电子版) ›› 2017, Vol. 11 ›› Issue (03) : 179 -181. doi: 10.3877/cma.j.issn.1674-0807.2017.03.012

综述

多西紫杉醇药物浓度-时间曲线下面积给药方式在乳腺癌患者中的应用
宋艳莉1, 周冬仙1,()   
  1. 1.518020 深圳市人民医院(暨南大学附属第二临床医学院)乳腺甲状腺外科
  • 收稿日期:2016-08-26 出版日期:2017-06-01
  • 通信作者: 周冬仙

Drug application based on area under docetaxel concentration-time curve in breast cancer patients

Yanli Song, Dongxian Zhou()   

  • Received:2016-08-26 Published:2017-06-01
  • Corresponding author: Dongxian Zhou
引用本文:

宋艳莉, 周冬仙. 多西紫杉醇药物浓度-时间曲线下面积给药方式在乳腺癌患者中的应用[J/OL]. 中华乳腺病杂志(电子版), 2017, 11(03): 179-181.

Yanli Song, Dongxian Zhou. Drug application based on area under docetaxel concentration-time curve in breast cancer patients[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2017, 11(03): 179-181.

多西紫杉醇是一种半合成的紫杉烷类抗肿瘤药物。 其通过抗微管作用抑制细胞分裂增殖,达到抑制肿瘤的目的,因此,在各期乳腺癌中均有较广泛的应用。 由于其血液学不良反应大,临床上个体间用药剂量差异明显,甚至出现不规范用药现象。 为了使用更高的药物剂量去获得患者的最大耐受,使患者得到以最佳治疗效果和最小不良反应为目的的精准治疗,笔者对多西紫杉醇的药代动力学及其与化疗不良反应的关系,以及依据体表面积和依据药物浓度-时间曲线下面积给药方式的相关研究进展作一综述,以期为临床上合理调节用药量提供参考。

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