切换至 "中华医学电子期刊资源库"

中华乳腺病杂志(电子版) ›› 2017, Vol. 11 ›› Issue (01) : 47 -49. doi: 10.3877/cma.j.issn.1674-0807.2017.01.010

综述

调节性T 细胞在乳腺癌免疫治疗中的作用
王雪霏1, 孙强1,(), 彭理1, 徐颖1, 赵佳琳1, 徐倩倩1, 陈畅1   
  1. 1.100730 中国医学科学院北京协和医学院北京协和医院乳腺外科
  • 收稿日期:2016-03-28 出版日期:2017-02-01
  • 通信作者: 孙强

Role of regulatory T cells in immunotherapy of breast cancer

Xuefei Wang, Qiang Sun(), Li Peng, Ying Xu, Jiali Zhao, Qianqin Xu, Chang Chen   

  • Received:2016-03-28 Published:2017-02-01
  • Corresponding author: Qiang Sun
引用本文:

王雪霏, 孙强, 彭理, 徐颖, 赵佳琳, 徐倩倩, 陈畅. 调节性T 细胞在乳腺癌免疫治疗中的作用[J/OL]. 中华乳腺病杂志(电子版), 2017, 11(01): 47-49.

Xuefei Wang, Qiang Sun, Li Peng, Ying Xu, Jiali Zhao, Qianqin Xu, Chang Chen. Role of regulatory T cells in immunotherapy of breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2017, 11(01): 47-49.

免疫治疗是利用免疫系统来治疗疾病。 近年来,随着免疫学的深入研究,免疫治疗开始应用于包括肿瘤在内的多种疾病,并显示出其独特的疗效。 相关研究发现,调节性T 细胞(Treg)是一群具有免疫抑制功能的T 细胞,是肿瘤浸润性淋巴细胞中起到免疫抑制作用的关键细胞。 乳腺癌免疫治疗包括主动免疫治疗和被动免疫治疗。 笔者重点阐述以Treg 为靶点的免疫治疗最新研究成果及其在免疫治疗中的地位,以期为乳腺癌的进一步相关研究提供参考。

[1]
Bahl S, Roses RE, Sharma A, et al. Asymptomatic changes in cardiac function can occur in ductal carcinoma-in-situ patients following treatment with HER-2/neu-pulsed dendritic cell vaccines [J]. Am J Surg,2009,198(4):488-494.
[2]
张欢,吴斌. 乳腺癌免疫治疗的研究进展[J/CD]. 中华乳腺病杂志(电子版),2015,9(4):264-269.
[3]
Wiedermann U,Wiltschke C,Jasinska J,et al. A virosomal formulated Her-2/neu multi-peptide vaccine induces Her-2/neu-specific immune responses in patients with metastatic breast cancer: a phase I study[J]. Breast Cancer Res Treat,2010,119(3):673-683.
[4]
Pichinuk E, Benhar I, Jacobi O, et al. Antibody targeting of cellbound MUC1 SEA domain kills tumor cells[J]. Cancer Res,2012,72(13):3324-3336.
[5]
Shumway NM, Ibrahim N, Ponniah S, et al. Therapeutic breast cancer vaccines: a new strategy for early-stage disease [J]. Bio Drugs,2009,23(5):277-287.
[6]
Strauss L,Bergmann C,Szczepanski M,et al. A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta 1 mediates suppression in the tumor microenvironment[J]. Clin Cancer Res,2007,13(15 Pt 1):4345-4354.
[7]
Sakaguchi S, Miyara M, Costantino CM, et al. FOXP3+ regulatory T cells in the human immune system[J]. Nat Rev Immunol, 2010,10(7):490-500.
[8]
Byrne WL, Mills KH, Lederer JA, et al. Targeting regulatory T cells in cancer[J]. Cancer Res,2011,71(22):6915-6920.
[9]
Cao X, Cai SF, Fehniger TA, et al. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance[J]. Immunity,2007,27(4):635-646.
[10]
于海明,杨俊兰,焦顺昌.乳腺癌肿瘤免疫微环境研究进展[J]. 解放军医学院学报,2013,34(6):664-666,669.
[11]
任莉莉,邓春艳,蒋锦杏,等. 细胞免疫治疗对乳腺癌患者Treg 细胞表达的影响[J]. 山西医科大学学报,2015,46(7):672-675.
[12]
Gobert M, Treilleux I, Bendriss-Vermare N, et al. Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome [J]. Cancer Res,2009,69(5):2000-2009.
[13]
Liu F,Lang R, Zhao J, et al. CD8+ cytotoxic T cell and FOXP3+regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes[J]. Breast Cancer Res Treat,2011,130 (2):645-655.
[14]
Aruga T, Suzuki E, Saji S, et al. A low number of tumor-infiltrating FOXP3-positive cells during primary systemic chemotherapy correlates with favorable anti-tumor response in patients with breast cancer[J].Oncol Rep,2009,22(2):273-278.
[15]
Zou W. Regulatory T cells, tumour immunity and immunotherapy [J].Nat Rev Immunol,2006,6(4):295-307.
[16]
Beyer M, Schultze JL. Regulatory T cells in cancer [J]. Blood,2006,108(3):804-811.
[17]
Nakanishi J, Wada Y, Matsumoto K, et al. Overexpression of B7-H1(PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers [J]. Cancer Immunol Immunother,2007,56(8):1173-1182.
[18]
Curiel TJ,Wei S,Dong H,et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity [J]. Nat Med, 2003,9(5):562-567.
[19]
Ohaegbulam KC, Assal A, Lazar-Molnar E, et al. Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway [J].Trends Mol Med,2015,21(1):24-33.
[20]
Raedler LA. Opdivo (nivolumab):second PD-1 inhibitor receives FDA approval for unresectable or metastatic melanoma[J]. Am Health Drug Benefits,2015,8(Spec Feature):180-183.
[21]
Sigal LH. Basic science for the clinician 55: CTLA-4 [J]. J Clin Rheumatol,2012,18(3):155-158.
[22]
Wang XY,Zuo D,Sarkar D,et al. Blockade of cytotoxic T-lymphocyte antigen-4 as a new therapeutic approach for advanced melanoma [J].Expert Opin Pharmacother,2011,12(17):2695-2706.
[23]
李明月. MMPs 抑制剂通过改善肿瘤微环境提高CTLA-4 抗体治疗乳腺癌的实验研究[D].长春:吉林大学,2015.
[24]
王建霞. 联合抗CTLA-4 抗体及JAK2 抑制剂治疗小鼠乳腺癌的实验研究[D]. 长春:吉林大学,2014.
[25]
沈文状,董鸿,张林,等. 抗CTLA-4 抗体联合阿霉素治疗小鼠乳腺癌的疗效及机制分析[J]. 重庆医学,2015,44(23):3172-3175.
[26]
Lakshmi Narendra B, Eshvendar Reddy K, Shantikumar S, et al.Immune system: a double-edged sword in cancer [J]. Inflamm Res,2013,62(9):823-834.
[27]
Kim HJ, Barnitz RA, Kreslavsky T, et al. Stable inhibitory activity of regulatory T cells requires the transcription factor Helios[J]. Science,2015,350(6258):334-339.
[1] 李洋, 蔡金玉, 党晓智, 常婉英, 巨艳, 高毅, 宋宏萍. 基于深度学习的乳腺超声应变弹性图像生成模型的应用研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 563-570.
[2] 周荷妹, 金杰, 叶建东, 夏之一, 王进进, 丁宁. 罕见成人肋骨郎格汉斯细胞组织细胞增生症被误诊为乳腺癌术后骨转移一例[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 380-383.
[3] 河北省抗癌协会乳腺癌专业委员会护理协作组. 乳腺癌中心静脉通路护理管理专家共识[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 321-329.
[4] 刘晨鹭, 刘洁, 张帆, 严彩英, 陈倩, 陈双庆. 增强MRI 影像组学特征生境分析在预测乳腺癌HER-2 表达状态中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 339-345.
[5] 张晓宇, 殷雨来, 张银旭. 阿帕替尼联合新辅助化疗对三阴性乳腺癌的疗效及预后分析[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 346-352.
[6] 邱琳, 刘锦辉, 组木热提·吐尔洪, 马悦心, 冷晓玲. 超声影像组学对致密型乳腺背景中非肿块型乳腺癌的诊断价值[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 353-360.
[7] 程燕妮, 樊菁, 肖瑶, 舒瑞, 明昊, 党晓智, 宋宏萍. 乳腺组织定位标记夹的应用与进展[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 361-365.
[8] 涂盛楠, 胡芬, 张娟, 蔡海峰, 杨俊泉. 天然植物提取物在乳腺癌治疗中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 366-370.
[9] 朱文婷, 顾鹏, 孙星. 非酒精性脂肪性肝病对乳腺癌发生发展及治疗的影响[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 371-375.
[10] 韩萌萌, 冯雪园, 马宁. 乳腺癌改良根治术后桡神经损伤1例[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 117-118.
[11] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[12] 张志兆, 王睿, 郜苹苹, 王成方, 王成, 齐晓伟. DNMT3B与乳腺癌预后的关系及其生物学机制[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 624-629.
[13] 王玲艳, 高春晖, 冯雪园, 崔鑫淼, 刘欢, 赵文明, 张金库. 循环肿瘤细胞在乳腺癌新辅助及术后辅助治疗中的应用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 630-633.
[14] 赵林娟, 吕婕, 王文胜, 马德茂, 侯涛. 超声引导下染色剂标记切缘的梭柱型和圆柱型保乳区段切除术的效果研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 634-637.
[15] 陈伟杰, 何小东. 胆囊癌免疫靶向治疗进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 763-768.
阅读次数
全文


摘要