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中华乳腺病杂志(电子版) ›› 2017, Vol. 11 ›› Issue (01) : 50 -54. doi: 10.3877/cma.j.issn.1674-0807.2017.01.011

综述

长链非编码RNA 在乳腺癌中的研究进展
吴莹莹1, 黄劲龙2,()   
  1. 1.362200 福建省晋江市医院妇产科
    2.350001 福建医科大学附属协和医院血液病研究所
  • 收稿日期:2016-03-08 出版日期:2017-02-01
  • 通信作者: 黄劲龙

Research progress of long noncoding RNAs in breast cancer

Yingying Wu, Jinlong Huang()   

  • Received:2016-03-08 Published:2017-02-01
  • Corresponding author: Jinlong Huang
引用本文:

吴莹莹, 黄劲龙. 长链非编码RNA 在乳腺癌中的研究进展[J/OL]. 中华乳腺病杂志(电子版), 2017, 11(01): 50-54.

Yingying Wu, Jinlong Huang. Research progress of long noncoding RNAs in breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2017, 11(01): 50-54.

长链非编码RNA(lncRNA)与肿瘤的关联逐渐成为研究的热点,其在致癌与肿瘤抑制中的作用需要进一步阐明。 乳腺癌是女性最常见的恶性肿瘤,严重危害女性的身心健康。 多种lncRNA在乳腺癌中异常表达,同时也与乳腺癌干细胞的形成有关。 笔者对乳腺癌中异常表达的lncRNA 及其与肿瘤发生、发展的关系进行综述,以期为乳腺癌的诊疗提供新的思路。

表1 乳腺癌组织中异常表达的lncRNA
lncRNA 染色体位置 表达水平 主要作用
ARA[34] Xq23 上调 沉默ARA可增加肿瘤对多柔比星的敏感性,抑制细胞增殖及转移,并促进细胞凋亡
BC200/BCYRN1[35-36] 2p21 上调 BC200表达与肿瘤的高核分级相关,预示肿瘤的增殖行为,可作为肿瘤进展的预后标志物
CCAT2[37-38] 8q24.21 上调 CCAT2表达可增强肿瘤细胞增殖、迁移能力,同时降低对化疗的敏感性
GAS5[9,39] 1q25.1 下调 GAS5表达可诱导肿瘤细胞生长停滞,促进细胞凋亡,增加化疗敏感性
HOTAIR[5] 12q13.13 上调 HOTAIR是肿瘤转移与预后不良的重要标志物,下调HOTAIR可抑制肿瘤侵袭
H19[40] 11p15.5 上调 H19高表达可促进肿瘤细胞增殖与转移
JADE[41] 4q28.2 上调 JADE参与影响DNA损伤反应,下调JADE可抑制乳腺肿瘤的生长
Loc554202(MIR31HG)[42] 9p21.3 上调 与病理分期及肿瘤大小有关,下调Loc554202可抑制肿瘤细胞增殖、侵袭和转移,诱导细胞凋亡
LSINCT5[16] 5p15.33 上调 下调LSINCT5可抑制肿瘤细胞增殖
ROR[23] 18q21.31 上调 ROR高表达可促进肿瘤细胞增殖、侵袭和转移,抑制p53基因介导的细胞周期停滞及凋亡
MALAT1[19,43] 11q13.1 上调 MALAT1高表达促进肿瘤细胞的增殖、侵袭和转移
PANDA[44-45] 6p21.2 上调 过表达PANDA可阻断蒽环类药物的抗肿瘤作用
SRA[24] 5q31.3 上调 SRA通过激活ER来促进细胞增殖
TreRNA[46] 20q13 上调 TreRNA高表达促进肿瘤细胞增殖、侵袭和转移
UCA1[27] 19p13.12 上调 UCA1高表达有致瘤作用,促进肿瘤细胞的增殖
XIST[30-31] Xq13.2 缺失 XIST参与BRCA1基因介导的表观遗传修饰,与X染色体失活有关
ZFAS1[33] 20q13.13 下调 ZFAS1参与乳腺发育,可抑制细胞增殖与分化
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