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中华乳腺病杂志(电子版) ›› 2016, Vol. 10 ›› Issue (01) : 47 -49. doi: 10.3877/cma.j.issn.1674-0807.2016.01.011

综述

PDZK1 基因在ER 阳性乳腺癌中的研究进展
崔智淼1, 骆成玉1,()   
  1. 1.100038 北京,首都医科大学附属复兴医院普外科
  • 收稿日期:2015-10-08 出版日期:2016-02-01
  • 通信作者: 骆成玉

Research progress on PDZK1 gene in ER positive breast cancer

Zhimiao Cui, Chengyu Luo()   

  • Received:2015-10-08 Published:2016-02-01
  • Corresponding author: Chengyu Luo
引用本文:

崔智淼, 骆成玉. PDZK1 基因在ER 阳性乳腺癌中的研究进展[J/OL]. 中华乳腺病杂志(电子版), 2016, 10(01): 47-49.

Zhimiao Cui, Chengyu Luo. Research progress on PDZK1 gene in ER positive breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2016, 10(01): 47-49.

乳腺癌是女性最常见的恶性肿瘤之一,其中大部分为ER 阳性。 乳腺癌的发生、发展是一个多病因、多阶段、多因素共同作用的复杂过程。 PDZK1 基因是乳腺癌易感基因之一,其在ER 阳性乳腺癌中表达明显升高,相关机制可能包括Akt 磷酸化、MEK/ERK1/2 及HER-2/neu 信号通路等。 笔者总结了PDZK1 基因的结构、功能及其在ER 阳性乳腺癌中的研究进展。

图1 PDZK1 基因在乳腺癌细胞中的作用机制
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