切换至 "中华医学电子期刊资源库"

中华乳腺病杂志(电子版) ›› 2011, Vol. 05 ›› Issue (06) : 713 -720. doi: 10.3877/cma.j.issn.1674-0807.2011.06.008

综述

缝隙连接在乳腺疾病发生发展中的作用
明佳1, 范林军1, 姜军1   
  1. 1.400038 重庆,第三军医大学西南医院乳腺疾病中心
  • 收稿日期:2010-11-10 出版日期:2011-12-01
  • 基金资助:
    重庆市自然科学基金资助项目(2008BB5102)

Role of gap junction in the development and progression of breast disease

Jia MING, Linjun FAN, Jun JIANG   

  • Received:2010-11-10 Published:2011-12-01
引用本文:

明佳, 范林军, 姜军. 缝隙连接在乳腺疾病发生发展中的作用[J/OL]. 中华乳腺病杂志(电子版), 2011, 05(06): 713-720.

Jia MING, Linjun FAN, Jun JIANG. Role of gap junction in the development and progression of breast disease[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2011, 05(06): 713-720.

[1]
Lamote I, Meyer E, Massart-Leen AM, et al. Sex steroids and growth factors in the regulation of mammary gland proliferation, differentiation, and involution[J]. Steroids,2004,69(3):145-159.
[2]
Parthasarathi K, Ichimura H, Monma E, et al. Connexin 43 mediates spread of Ca2+ dependent proinflammatory responses in lung capillaries[J]. J Clin Invest,2006,116(8):2193-2200.
[3]
Goldberg GS, Moreno AP, Lampe PD. Gap junctions between cells expressing connexin 43 or 32 show inverse perselectivity to adenosine and ATP[J]. J Biol Chem,2002,277(39):36 725-36 730.
[4]
Conklin CM, Bechberger JF, MacFabe D, et al. Genistein and quercetin increase connexin 43 and suppress growth of breast cancer cells[J]. Carcinogenesis,2007,28(1):93-100.
[5]
Saunders MM, Seraj MJ, Li Z, et al. Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication[J]. Cancer Res,2001,61(5):1765-1767.
[6]
Monaghan P, Clarke C, Perusinghe NP, et al. Gap junction distribution and connexin expression in human breast[J].Exp Cell Res,1996,223(1):29-38.
[7]
Monaghan P, Moss D. Connexin expression and gap junctions in the mammary gland[J]. Cell Biol Int,1996,20(2):121-125.
[8]
Talhouk RS, Elble RC, Bassam R, et al. Developmental expression patterns and regulation of connexins in the mouse mammary gland: expression of connexin30 in lactogenesis[J]. Cell Tissue Res,2005,319(1):49-59.
[9]
Locke D, Jamieson S, Stein T, et al. Nature of Cx30- containing channels in the adult mouse mammary gland[J]. Cell Tissue Res,2006,328(1):97-107.
[10]
Pozzi A, Risek B, Kiang DT, et al. Analysis of multiple gap junction gene products in the rodent and human mammary gland[J]. Exp Cell Res,1995,220(1):212-219.
[11]
Lambe T, Finlay D, Murphy M, et al. Differential expression of connexin 43 in mouse mammary cells[J]. Cell Biol Int,2006,30(5):472-479.
[12]
Bry C, Maass K, Miyoshi K, et al. Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired development[J]. Dev Biol,2004,267(2):418-429.
[13]
Locke D, Stein T, Davies C, et al. Altered permeability and modulatory character of connexin channels during mammary gland development[J]. Exp Cell Res,2004,298(2):643-660.
[14]
Reaume AG, de Sousa PA, Kulkarni S,et al. Cardiac malformation in neonatal mice lacking connexin 43[J]. Science,1995,267(5205):1831-1834.
[15]
Plum A, Hallas G, Magin T, et al. Unique and shared functions of different connexins in mice[J]. Curr Biol, 2000,10(18):1083-1091.
[16]
Kanczuga-Koda L,Sulkowski S,Tomaszewski J,et al. Connexins 26 and 43 correlate with Bak,but not with Bcl-2 protein in breast cancer[J]. Oncol Rep,2005,14(2):325-329.
[17]
Oktem G,Bilir A,Ayla S,et al. Role of intercellular communications in breast cancer multicellular tumor spheroids after chemotherapy[J]. Oncol Res,2006,16(5):225-233.
[18]
Lee SW, Tomasetto C, Paul D, et al. Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines[J]. J Cell Biol,1992,118(5):1213-1221.
[19]
Zhang YW, Nakayama K, Morita I. A novel route for connexin 43 to inhibit cell proliferation: negative regulation of S-phase kinase-associated protein (Skp2) [J]. Cancer Res,2003,63(7):1623-1630.
[20]
Rosenkranz HS, Pollack N, Cunningham AR. Exploring the relationship between the inhibition of gap junctional intercellular communication and other biological phenomena[J]. Carcinogenesis,2000,21(5):1007-1011.
[21]
Tan LW, Bianco T, Dobrovic A. Variable promoter region CpG island methylation of the putative tumor suppressor gene connexin 26 in breast cancer[J]. Carcinogenesis,2002,23(2):231-236.
[22]
Singal R, Tu ZJ, Vanwert JM, et al. Modulation of the connexin26 tumor suppressor gene expression through methylation in human mammary epithelial cell lines[J]. Anticancer Res,2000,20(1A):59-64.
[23]
Jamieson S, Going JJ, D'Arcy R, et al. Expression of gap junction proteins connexin 26 and connexin 43 in normal human breast and in breast tumours[J]. J Pathol,1998,184(1):37-43.
[24]
Gould VE, Mosquera JM,Leykauf K,et al. The phosphorylated form of connexin 43 is up-regulated in breast hyperplasias and carcinomas and in their neoformed capillaries[J]. Hum Pathol,2005,36(5):536-545.
[25]
Naoi Y, Miyoshi Y, Taguchi T, et al. Connexin 26 expression is associated with lymphatic vessel invasion and poor prognosis in human breast cancer[J]. Breast Cancer Res Treat,2007,106(1):11-17.
[26]
McLachlan E, Shao Q, Wang HL, et al. Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis [J]. Cancer Res,2006,66(20):9886-9894.
[27]
Kanczuga-Koda L, Sulkowski S, Lenczewski A, et al. Increased expression of connexins 26 and 43 in lymph node metastases of breast cancer[J]. J Clin Pathol,2006,59(4):429-433.
[28]
Park SY, Lee HE, Li H, et al. Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer[J]. Clin Cancer Res,2010,16(3):876-887.
[29]
Li Z, Zhou Z, Welch DR, et al. Expressing connexin 43 in breast cancer cells reduces their metastasis to lungs[J]. Clin Exp Metastasis,2008,25(8):893-901.
[30]
Pollmann MA, Shao Q, Laird DW, et al. Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture[J]. Breast Cancer Res,2005,7(4):R522-534.
[31]
Elzarrad MK, Haroon A, Willecke K, et al. Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium[J]. BMC Med,2008,6:20-35.
[32]
Cai J,Jiang WG,Mansel RE. Gap junctional communication and the tyrosine phosphorylation of connexin 43 in interaction between breast cancer and endothelial cells[J]. Int J Mol Med,1998,1(1):273-278.
[33]
Bellahcene A, Bachelier R, Detry C, et al. Transcriptome analysis reveals an osteoblast-like phenotype for human osteotropic breast cancer cells[J]. Breast Cancer Res Treat,2007,101(2):135-148.
[34]
Moharita AL,Taborga M,Corcoran KE,et al. SDF-1alpha regulation in breast cancer cells contacting bone marrow stroma is critical for normal hematopoiesis[J]. Blood,2006,108(10):3245-3252.
[35]
MaLachlan E, Shao Q, Laird DW. Connexins and gap junctions in mammary gland development and breast cancer progression[J]. J Membr Biol,2007,218(1/3):107-121.
[1] 李洋, 蔡金玉, 党晓智, 常婉英, 巨艳, 高毅, 宋宏萍. 基于深度学习的乳腺超声应变弹性图像生成模型的应用研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 563-570.
[2] 河北省抗癌协会乳腺癌专业委员会护理协作组. 乳腺癌中心静脉通路护理管理专家共识[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 321-329.
[3] 刘晨鹭, 刘洁, 张帆, 严彩英, 陈倩, 陈双庆. 增强MRI 影像组学特征生境分析在预测乳腺癌HER-2 表达状态中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 339-345.
[4] 张晓宇, 殷雨来, 张银旭. 阿帕替尼联合新辅助化疗对三阴性乳腺癌的疗效及预后分析[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 346-352.
[5] 邱琳, 刘锦辉, 组木热提·吐尔洪, 马悦心, 冷晓玲. 超声影像组学对致密型乳腺背景中非肿块型乳腺癌的诊断价值[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 353-360.
[6] 程燕妮, 樊菁, 肖瑶, 舒瑞, 明昊, 党晓智, 宋宏萍. 乳腺组织定位标记夹的应用与进展[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 361-365.
[7] 涂盛楠, 胡芬, 张娟, 蔡海峰, 杨俊泉. 天然植物提取物在乳腺癌治疗中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 366-370.
[8] 朱文婷, 顾鹏, 孙星. 非酒精性脂肪性肝病对乳腺癌发生发展及治疗的影响[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 371-375.
[9] 周荷妹, 金杰, 叶建东, 夏之一, 王进进, 丁宁. 罕见成人肋骨郎格汉斯细胞组织细胞增生症被误诊为乳腺癌术后骨转移一例[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 380-383.
[10] 葛睿, 陈飞, 李杰, 李娟娟, 陈涵. 多基因检测在早期乳腺癌辅助治疗中的应用价值[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(05): 257-263.
[11] 韩萌萌, 冯雪园, 马宁. 乳腺癌改良根治术后桡神经损伤1例[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 117-118.
[12] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[13] 张志兆, 王睿, 郜苹苹, 王成方, 王成, 齐晓伟. DNMT3B与乳腺癌预后的关系及其生物学机制[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 624-629.
[14] 王玲艳, 高春晖, 冯雪园, 崔鑫淼, 刘欢, 赵文明, 张金库. 循环肿瘤细胞在乳腺癌新辅助及术后辅助治疗中的应用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 630-633.
[15] 赵林娟, 吕婕, 王文胜, 马德茂, 侯涛. 超声引导下染色剂标记切缘的梭柱型和圆柱型保乳区段切除术的效果研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 634-637.
阅读次数
全文


摘要