目的

探讨85 例单乳单孔乳白色乳头溢液临床因素与病理检查结果的关系。

方法

回顾性分析2004 年6 月至2009 年5 月本院收治的85 例单乳单孔乳白色乳头溢液患者的临床因素与病理检查结果的关系。 定性资料的比较采用两样本率χ² 检验或连续性校正χ² 检验。

结果

本组患者中，乳腺癌患者约占14.12%（12/85），年龄＞50岁的乳腺癌患者比年龄≤50岁者多见（χ² =14.43，P=0.00）；绝经期乳腺癌患者比未绝经者多见（χ² =33.27，P=0.00）；病程＞12个月的乳腺癌患者比病程≤12个月者多见（χ²=8.89，P=0.00）；乳管内占位距离乳头距离＞2 cm的乳腺癌患者比≤2 cm者多见（χ²=24.04，P=0.00）；伴有肿块的乳腺癌患者比不伴肿块者多见（χ²=20.64，P=0.00）；左侧乳头溢液患者乳腺癌发生率与右侧乳头溢液患者间差异无统计学意义（χ²=0.00，P=0.76）。 纤维乳管镜诊断乳腺癌的灵敏度为83.33% （10/12）。

结论

单乳单孔乳白色乳头溢液患者乳腺癌风险较高，多见于年龄＞50 岁、绝经期、病程≥12 个月和乳管内占位距离乳头＞2 cm 的患者，并多伴有肿块，临床不可忽视。 纤维乳管镜对单乳单孔乳白色乳头溢液患者的乳腺癌诊断符合率较高。

Objective

To explore the relation between the pathological results and clinical data in 85 cases of white nipple discharge from single breast duct.

Methods

Retrospective analysis of the relation between the pathological results and clinical data in 85 cases of white nipple discharge from single breast duct treated in our hospital from June 2004 to May 2009.Chi-square test or continuity correction chi-square was used for statistical analysis.

Results

Of the 85 cases，12 had breast cancer， occupying 14.12%.In the 12 breast cancer cases， patients aged ＞50 years were more than those aged ≤50 （χ² =14.43，P=0.00）， perimenopausal patients were more than non-menopausal ones （χ² =33.27，P=0.00）， patients with disease course ＞12 months were more than those≤12 months（χ²=8.89，P=0.00），patients with intraductal lesion＞2 cm from the nipple were more than those ≤2 cm from the nipple（χ²=24.04，P=0.00）， patients with mass were more than those without mass（χ²=20.64，P=0.00）， but patients with nipple discharge of the left breast had no statistical difference with those with nipple discharge of the right breast（χ²=0.00，P=0.76）.The sensitivity of fiberoptic ductoscopy（FDS） was 83.33% （10/12）.

Conclusions

Breast cancer can occur in white nipple discharge from single breast duct.Patients with age ＞50 years， postmenopause， disease course ＞12 months and intraductal lesion ＞2 cm from the nipple are common， and most patients have mass.So enough attention should be given.The diagnoses accordance rate of FDS for breast cancer is high in white nipple discharge from single breast duct.