切换至 "中华医学电子期刊资源库"

中华乳腺病杂志(电子版) ›› 2010, Vol. 04 ›› Issue (01) : 99 -105. doi: 10.3877/cma.j.issn.1674-0807.2010.01.015

综述

人类组织激肽释放酶基因与乳腺癌关系的研究进展
李梅芳1, 何建蓉1,()   
  1. 1.20025 上海,上海交通大学医学院附属瑞金医院乳腺疾病诊治中心
  • 收稿日期:2009-04-21 出版日期:2010-02-01
  • 通信作者: 何建蓉
  • 基金资助:
    上海教育委员会重点学科建设项目资助(J50208)

Advances in the study of the relationship between human tissue kallikrein gene and breast cancer

Mei-fang LI, Jianrong He()   

  • Received:2009-04-21 Published:2010-02-01
  • Corresponding author: Jianrong He
引用本文:

李梅芳, 何建蓉. 人类组织激肽释放酶基因与乳腺癌关系的研究进展[J/OL]. 中华乳腺病杂志(电子版), 2010, 04(01): 99-105.

Mei-fang LI, Jianrong He. Advances in the study of the relationship between human tissue kallikrein gene and breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2010, 04(01): 99-105.

图1 人类组织激肽释放酶基因座的结构 箭头的方向表示基因转录的方向,绿色表示为传统经典的KLK,蓝色表示为非经典的KLK。
图2 人类组织激肽释放酶基因和蛋白质的结构 盒子结构表示为外显子,线性结构表示为内含子,H 代表组氨酸,D 代表天冬氨酸,S代表丝氨酸。Ⅰ代表Ⅰ型内含子,Ⅱ代表Ⅱ型内含子,0代表0型内含子。
[1]
梁燕,范林军.老年乳腺癌的临床流行病学.中华乳腺病杂志:电子版,2008,2:61-62.
[2]
郑一琼,李席如,李荣.乳腺癌保乳综合治疗的进展.中华乳腺病杂志:电子版,2008,2:35-41.
[3]
Emami N,Diamandis EP.Human tissue kallikreins:a road under construction.Clin Chim Acta 2007,381:78-84.
[4]
Borgono CA,Michael IP,Diamandis EP.Human tissue kallikreins:physiologic roles and applications in cancer.Mol Cancer Res,2004,2:257-280.
[5]
Klein EA.What's new in prostate cancer screening and prevention?Cleve Clin J Med,2009,76:439-445.
[6]
Planque C,Li L,Zheng Y,et al.A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma.Clin Cancer Res,2008,14:1355-1362.
[7]
Talieri M,Li L,Zheng Y,et al.The use of kallikrein-related peptidases as adjuvant prognostic markers in colorectal cancer.Br J Cancer,2009,100:1659-1665.
[8]
Yu H,Levesque MA,Clark GM,et al.Prognostic value of prostate-specific antigen for women with breast cancer:a large United States cohort study.Clin Cancer Res,1998,4:1489-1497.
[9]
Narita D,Cimpean AM,Anghel A,et al.Prostate-specific antigen value as a marker in breast cancer.Neoplasma,2006,53:161-167.
[10]
Black MH,Diamandis EP.The diagnostic and prognostic utility of prostate-specific antigen for diseases of the breast.Breast Cancer Res Treat,2000,59:1-14.
[11]
Borchert GH,Giai M,Diamandis EP.Elevated levels of prostate-specific antigen in serum of women with fibroadenomas and breast cysts.J Natl Cancer Inst,1997,89:587-588.
[12]
Borchert GH,Melegos DN,Tomlinson G,et al.Molecular forms of prostate-specific antigen in the serum of women with benign and malignant breast diseases.Br J Cancer,1997,76:1087-1094.
[13]
Giai M,Yu H,Roagna R,et al.Prostate-specific antigen in serum of women with breast cancer.Br J Cancer,1995,72:728-731.
[14]
Sauter ER,Daly M,Lenahan K,et al.Prostate-specific antigen levels in nipple aspirate fluid correlate with breast cancer risk.Cancer Epidemiol Biomarkers Prev,1996,5:967-970,
[15]
Sauter ER,Babb J,Daly M,et al.Prostate-specific antigen production in the female breast:association with progesterone.Cancer Epidemiol Biomarkers Prev,1998 7:315-320,
[16]
Sauter ER,Klein G,Wagner Mann C,et al.Prostate-specific antigen expression in nipple aspirate fluid is associated with advanced breast cancer.Cancer Detect Prev,2004,28:27-31.
[17]
Liu XL,Wazer DE,Watanabe K,et al.Identification of a novel serine protease-like gene,the expression of which is downregulated during breast cancer progression.Cancer Res,1996,56:3371-3379.
[18]
Goyal J,Smith KM,Cowan JM,et al.The role for NES1 serine protease as a novel tumor suppressor.Cancer Res,1998,58:4782-4786.
[19]
Li B,Goyal J,Dhar S,et al.CpG methylation as a basis for breast tumor-specific loss of NES1/kallikrein 10 expression.Cancer Res,2001,61:8014-8021.
[20]
Kioulafa M,Kaklamanis L,Stathopoulos E,et al.Kallikrein 10(KLK10)methylation as a novel prognostic biomarker in early breast cancer.Ann Oncol,2009,20:1020-1025..
[21]
Luo LY,Diamandis EP,Look MP,et al.Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance.Br J Cancer,2002,86:1790-1796.
[22]
Feng B,Xu WB,Zheng MH,et al.Clinical significance of human kallikrein 10 gene expression in colorectal cancer and gastric cancer.J Gastroenterol Hepatol,2006,21:1596-1603.
[23]
Holzscheiter L,Biermann J C,Kotzsch M,et al.Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7:prognostic relevance of KLK7 mRNA expression in breast cancer.Clin Chem,2006,52:1070-1079.
[24]
Yousef GM,Yacoub GM,Polymeris ME,et al.Kallikrein gene downregulation in breast cancer.Br J Cancer,2004,90:167-172.
[25]
Yousef GM,Scorilas A,Nakamura T,et al.The prognostic value of the human kallikrein gene 9(KLK9)in breast cancer.Breast Cancer Res Treat,2003,78:149-158.
[26]
Yousef GM,Magklara A,Diamandis EP.KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer.Genomics,2000,69:331-341.
[27]
Chang A,Yousef GM,Scorilas A,et al.Human kallikrein gene 13(KLK13)expression by quantitative RT-PCR:an independent indicator of favourable prognosis in breast cancer.Br J Cancer,2002,86:1457-1464.
[28]
Yousef GM,Scorilas A,Magklara A,et al.The androgen-regulated gene human kallikrein 15(KLK15)is an independent and favourable prognostic marker for breast cancer.Br J Cancer,2002,87:1294-1300,999.
[29]
Papachristopoulou G,Avgeris M,Scorilas A.Expression analysis and study of KLK4 in benign and malignant breast tumours.Thromb Haemost,2009,101:381-387.
[30]
Mange A,Desmetz C,Berthes ML,et al.Specific increase of human kallikrein 4 mRNA and protein levels in breast cancer stromal cells.Biochem Biophys Res Commun,2008,375:107-112.
[31]
Yousef GM,Scorilas A,Kyriakopoulou LG,et al.Human kallikrein gene 5(KLK5)expression by quantitative PCR:an independent indicator of poor prognosis in breast cancer.Clin Chem,2002,48:1241-1250.
[32]
Pampalakis G,Sotiropoulou G.Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer.Biol Chem,2006,387:773-782.
[33]
Sano A,Sangai T,Maeda H,et al.Kallikrein 11 expressed in human breast cancer cells releases insulin-like growth factor through degradation of IGFBP-3.Int J Oncol,2007,30:1493-1498.
[34]
Fritzsche F,Gansukh T,Borgono CA,et al.Expression of human Kallikrein 14(KLK14)in breast cancer is associated with higher tumour grades and positive nodal status.Br J Cancer,2006,94:540-547.
[35]
Borgono CA,Grass L,Soosaipillai A,et al.Human kallikrein 14:a new potential biomarker for ovarian and breast cancer.Cancer Res,2003,63:9032-9041.
[36]
Yousef GM,Borgono CA,Scorilas A,et al.Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis.Br J Cancer,2002,87:1287-1293.
[37]
Zhao W,Wang L,Lu X,et al.A coding polymorphism of the kallikrein 1 gene is associated with essential hypertension:a tagging SNP-based association study in a Chinese Han population.J Hypertens,2007,25:1821-1827.
[38]
Sardana G,Dowell B,Diamandis EP.Emerging biomarkers for the diagnosis and prognosis of prostate cancer.Clin Chem,2008,54:1951-1960.
[1] 李洋, 蔡金玉, 党晓智, 常婉英, 巨艳, 高毅, 宋宏萍. 基于深度学习的乳腺超声应变弹性图像生成模型的应用研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 563-570.
[2] 周荷妹, 金杰, 叶建东, 夏之一, 王进进, 丁宁. 罕见成人肋骨郎格汉斯细胞组织细胞增生症被误诊为乳腺癌术后骨转移一例[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 380-383.
[3] 河北省抗癌协会乳腺癌专业委员会护理协作组. 乳腺癌中心静脉通路护理管理专家共识[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 321-329.
[4] 刘晨鹭, 刘洁, 张帆, 严彩英, 陈倩, 陈双庆. 增强MRI 影像组学特征生境分析在预测乳腺癌HER-2 表达状态中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 339-345.
[5] 张晓宇, 殷雨来, 张银旭. 阿帕替尼联合新辅助化疗对三阴性乳腺癌的疗效及预后分析[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 346-352.
[6] 邱琳, 刘锦辉, 组木热提·吐尔洪, 马悦心, 冷晓玲. 超声影像组学对致密型乳腺背景中非肿块型乳腺癌的诊断价值[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 353-360.
[7] 程燕妮, 樊菁, 肖瑶, 舒瑞, 明昊, 党晓智, 宋宏萍. 乳腺组织定位标记夹的应用与进展[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 361-365.
[8] 涂盛楠, 胡芬, 张娟, 蔡海峰, 杨俊泉. 天然植物提取物在乳腺癌治疗中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 366-370.
[9] 朱文婷, 顾鹏, 孙星. 非酒精性脂肪性肝病对乳腺癌发生发展及治疗的影响[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 371-375.
[10] 葛睿, 陈飞, 李杰, 李娟娟, 陈涵. 多基因检测在早期乳腺癌辅助治疗中的应用价值[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(05): 257-263.
[11] 韩萌萌, 冯雪园, 马宁. 乳腺癌改良根治术后桡神经损伤1例[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 117-118.
[12] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[13] 张志兆, 王睿, 郜苹苹, 王成方, 王成, 齐晓伟. DNMT3B与乳腺癌预后的关系及其生物学机制[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 624-629.
[14] 王玲艳, 高春晖, 冯雪园, 崔鑫淼, 刘欢, 赵文明, 张金库. 循环肿瘤细胞在乳腺癌新辅助及术后辅助治疗中的应用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 630-633.
[15] 赵林娟, 吕婕, 王文胜, 马德茂, 侯涛. 超声引导下染色剂标记切缘的梭柱型和圆柱型保乳区段切除术的效果研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 634-637.
阅读次数
全文


摘要