切换至 "中华医学电子期刊资源库"

中华乳腺病杂志(电子版) ›› 2009, Vol. 03 ›› Issue (02) : 204 -209. doi: 10.3877/cma.j.issn.1674-0807.2009.02.011

综述

基因分型在乳腺癌个体化治疗中的应用
陈振东1, 李敏1, 陈娟1   
  1. 1.230022 合肥,安徽医科大学第一附属医院肿瘤内科
  • 收稿日期:2008-07-17 出版日期:2009-04-01

Genotyping in individual treatment of breast cancer

Zhendong Chen, Min Li, Juan Chen   

  • Received:2008-07-17 Published:2009-04-01
引用本文:

陈振东, 李敏, 陈娟. 基因分型在乳腺癌个体化治疗中的应用[J/OL]. 中华乳腺病杂志(电子版), 2009, 03(02): 204-209.

Zhendong Chen, Min Li, Juan Chen. Genotyping in individual treatment of breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2009, 03(02): 204-209.

表1 乳腺癌各基因亚型的蛋白质表达
表2 2007年圣安东尼奥乳腺癌会议有关基因分型的论文及其评价
[1]
Perou C M,S∅rlie T,Eisen M B,et al.Molecular portraits of human breast tumours.Nature,2000,406:747-752.
[2]
Sorlie T,Tibshirani R,Parker J,et al.Repeated observation of breast tumor subtypes in independent gene expression data sets.Proc Natl Acad Sci USA,2003,100:8418-8423.
[3]
Rouzier R,Perou C M,Symmans W F,et al.Breast cancer molecular subtypes respond differently to preoperative chemotherapy.Clin Cancer Res,2005,11:5678-5685.
[4]
Oratz R,Paul D,Cohn A,et al.Impact of oncotype DX on decision making in breast cancer clinical practice.Breast Cancer Res Treat,2006,100:S100.
[5]
Paik S,Shak S,Tang G,et al.A multigene assay to predict recurrence of tamoxifen-treated,node-negative breast cancer.N Engl J Med,2004,351:2817-2826.
[6]
Gianni L,Zambetti M,Clark K,et al.Gene expression profiles in paraffin-embedded core biopsy tissue predict response to chemotherapy in women with locally advanced breast cancer.J Clin Oncol,2005,23:7265-7277.
[7]
Lo S S,Norton J,Mumby P B,et al.Prospective multicenter study of the impact of the 21-gene recurrence score(RS)assay on medical oncologist(MO)and patient(pt)adjuvant breast cancer(BC)treatment selection.Proc Am Soc Clin Oncol,2007,25:22s.
[8]
Lyman G H,Cosler L E,Kuderer N M,et al.Impact of a 21-gene RT-PCR assay on treatment decisions in early-stage breast cancer:an economic analysis based on prognostic and predictive validation studies.Cancer,2007,109:1011-1018.
[9]
Hornberger J,Cosler L E,Lyman G H.Economic analysis of targeting chemotherapy using a 21-gene RT-PCRassay in lymph-node-negative,estrogen-receptor-positive,early-stage breast cancer.Am J Manag Care,2005,11:313-324.
[10]
Nielsen T O,Hsu F D,Jensen K,et al.Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma.Clin Cancer Res,2004,10:5367-5374.
[11]
Carey L A,Perou C M,Livasy C,et al.Race,breast cancer subtypes,and survival in the Carolina Breast Cancer Study.JAMA,2006,295:2492-2502.
[12]
Lalloo F,Varley J,Ellis D,et al.Prediction of pathogenic mutations in patients with early-onset breast cancer by family his-tory.Lancet,2003,361:1101-1102.
[13]
Goldstein L J,Gray R,Badve S,et al.Prognostic utility of the 21-gene assay in hormone receptor-positive operable breast cancer compared with classical clinicopathologic features.J Clin Oncol,2008,26:4063-4071.
[14]
Mook S,Van't Veer L J,Rutgers E J,et al.Individualization of therapy using Mammaprint:from development to the MINDACT Trial.Cancer Genomics Proteomics,2007,4:147-155.
[15]
Albain K,Barlow W,Shak S,et al.Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal,node-positive,ER-positive breast cancer(S8814,INT0100).Breast Cancer Res Treat,2007,106:LBA10.
[16]
Paik S,Shak S,Tang G,et al.Gene expression and benefit of chemotherapy in women with node-negative,estrogen receptor-positive breast cancer.J Clin Oncol,2006,24:3726-3734.
[17]
Carey L A,Dees E C,Sawyer L,et al.The triple negative paradox:primary tumor chemosensitivity of breast cancer subtypes.Clin Cancer Res,2007,15:2329-2334.
[18]
Cardoso F,Van't Veer L,Rutgers E,et al.Clinical application of the 70-gene profile:the MINDACT trial.J Clin Oncol,2008,26:729-735.
[19]
Liang H,Brufsky A M,Lembersky B B,et al.A retrospective analysis of the impact of oncotype DX low recurrence score results on treatment decisions in a single academic breast cancer center.Breast Cancer Res Treat,2007,106:S105.
[1] 李洋, 蔡金玉, 党晓智, 常婉英, 巨艳, 高毅, 宋宏萍. 基于深度学习的乳腺超声应变弹性图像生成模型的应用研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 563-570.
[2] 周荷妹, 金杰, 叶建东, 夏之一, 王进进, 丁宁. 罕见成人肋骨郎格汉斯细胞组织细胞增生症被误诊为乳腺癌术后骨转移一例[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 380-383.
[3] 河北省抗癌协会乳腺癌专业委员会护理协作组. 乳腺癌中心静脉通路护理管理专家共识[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 321-329.
[4] 刘晨鹭, 刘洁, 张帆, 严彩英, 陈倩, 陈双庆. 增强MRI 影像组学特征生境分析在预测乳腺癌HER-2 表达状态中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 339-345.
[5] 张晓宇, 殷雨来, 张银旭. 阿帕替尼联合新辅助化疗对三阴性乳腺癌的疗效及预后分析[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 346-352.
[6] 邱琳, 刘锦辉, 组木热提·吐尔洪, 马悦心, 冷晓玲. 超声影像组学对致密型乳腺背景中非肿块型乳腺癌的诊断价值[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 353-360.
[7] 程燕妮, 樊菁, 肖瑶, 舒瑞, 明昊, 党晓智, 宋宏萍. 乳腺组织定位标记夹的应用与进展[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 361-365.
[8] 涂盛楠, 胡芬, 张娟, 蔡海峰, 杨俊泉. 天然植物提取物在乳腺癌治疗中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 366-370.
[9] 朱文婷, 顾鹏, 孙星. 非酒精性脂肪性肝病对乳腺癌发生发展及治疗的影响[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 371-375.
[10] 葛睿, 陈飞, 李杰, 李娟娟, 陈涵. 多基因检测在早期乳腺癌辅助治疗中的应用价值[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(05): 257-263.
[11] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[12] 韩萌萌, 冯雪园, 马宁. 乳腺癌改良根治术后桡神经损伤1例[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 117-118.
[13] 张志兆, 王睿, 郜苹苹, 王成方, 王成, 齐晓伟. DNMT3B与乳腺癌预后的关系及其生物学机制[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 624-629.
[14] 王玲艳, 高春晖, 冯雪园, 崔鑫淼, 刘欢, 赵文明, 张金库. 循环肿瘤细胞在乳腺癌新辅助及术后辅助治疗中的应用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 630-633.
[15] 赵林娟, 吕婕, 王文胜, 马德茂, 侯涛. 超声引导下染色剂标记切缘的梭柱型和圆柱型保乳区段切除术的效果研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 634-637.
阅读次数
全文


摘要