切换至 "中华医学电子期刊资源库"

中华乳腺病杂志(电子版) ›› 2013, Vol. 07 ›› Issue (03) : 160 -167. doi: 10.3877/cma. j. issn.1674-0807.2013.03.003

专家论坛

乳腺癌的生物治疗进展
程琳1, 彭媛1, 王殊1,()   
  1. 1.100044 北京,北京大学人民医院乳腺中心
  • 收稿日期:2013-03-06 出版日期:2013-06-01
  • 通信作者: 王殊

Advances in biological treatment for breast cancer

Lin CHENG, Yuan PENG, Shu WANG()   

  • Received:2013-03-06 Published:2013-06-01
  • Corresponding author: Shu WANG
引用本文:

程琳, 彭媛, 王殊. 乳腺癌的生物治疗进展[J/OL]. 中华乳腺病杂志(电子版), 2013, 07(03): 160-167.

Lin CHENG, Yuan PENG, Shu WANG. Advances in biological treatment for breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2013, 07(03): 160-167.

[1]
Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network [J]. Nat Rev Mol Cell Biol,2001,2(2): 127-137.
[2]
Spector NL, Blackwell KL. Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2 positive breast cancer [J]. J Clin Oncol,2009,27(34): 5838-5847.
[3]
Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2 [J]. N Engl J Med,2001,344(11): 783-792.
[4]
Murphy CG, Morris PG. Recent advances in novel targeted therapies for HER2-positive breast cancer [J]. Anticancer Drugs,2012,23(8): 765-776.
[5]
Awada A, Bozovic-Spasojevic I, Chow L. New therapies in HER2-positive breast cancer: a major step towards a cure of the disease? [J]. Cancer Treat Rev,2012,38(5): 494-504.
[6]
Arteaga CL, Sliwkowski MX, Osborne CK, et al. Treatment of HER2-positive breast cancer: current status and future perspectives [J]. Nat Rev Clin Oncol,2011,9(1): 16-32.
[7]
Gianni L, Eiermann W, Semiglazov V, et al. Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone,in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort [J]. Lancet,2010,375(9712): 377-384.
[8]
Buzdar AU,Ibrahim NK,Francis D,et al. Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer [J]. J Clin Oncol,2005,23(16): 3676-3685.
[9]
Wong H, Leung R, Kwong A, et al. Integrating molecular mechanisms and clinical evidence in the management of trastuzumab resistant or refractory HER-2+ metastatic breast cancer [J]. Oncologist,2011,16(11): 1535-1546.
[10]
Gajria D, Chandarlapaty S. HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies [J]. Expert Rev Anticancer Ther,2011,11(2): 263-275.
[11]
Scaltriti M,Eichhorn PJ,Cortés J,et al. Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients[J]. Proc Natl Acad Sci U S A,2011,108(9): 3761-3766.
[12]
Lewis Phillips GD, Li G, Dugger DL, et al. Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibodycytotoxic drug conjugate [J]. Cancer Res,2008,68(22): 9280-9290.
[13]
Krop IE, Beeram M, Modi S, et al. Phase Ⅰ study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer [J]. J Clin Oncol,2010,28(16): 2698-2704.
[14]
Burris HA 3rd,Rugo HS, Vukelja SJ,et al. Phase Ⅱstudy of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy [J]. J Clin Oncol,2011,29(4): 398-405.
[15]
Krop IE, LoRusso P, Miller KD, et al. A phase Ⅱstudy of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab,lapatinib,an anthracycline,a taxane, and capecitabine [J]. J Clin Oncol,2012,30(26): 3234-3241.
[16]
Scheuer W, Friess T, Burtscher H, et al. Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment of HER2-positive human xenofraft tumor models [J].Cancer Res,2009,69(24): 9330-9336.
[17]
Baselga J, Gelmon KA, Verma S, et al. Phase Ⅱtrial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy [J]. J Clin Oncol,2010,28(7): 1138-1144.
[18]
Baselga J, Swain SM. CLEOPATRA: a phase Ⅲevaluation of pertuzumab and trastuzumab for HER2-positive metastatic breast cancer[J]. Clin Breast Cancer,2010,10(6): 489-491.
[19]
Baselga J, Cortés J, Kim SB, et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer [J]. N Engl J Med,2012,366(2): 109-119.
[20]
Gianni L, Pienkowski T, Im YH, et al. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer(NeoSphere): a randomised multicentre, open-label, phase 2 trial [J]. Lancet Oncol,2012,13(1): 25-32.
[21]
Schoeberl, B, Faber AC, Li D, et al. An ErbB3 antibody,MM121, is active in cancers with ligand-dependent activation[J]. Cancer Res,2010,70(6),2485-2494.
[22]
Gholam D, Chebib A, Hauteville D, et al. Combined paclitaxel and cetuximab achieved a major response on the skin metastases of a patient with epidermal growth factor receptor positive, estrogen receptor-negative, progesterone receptornegative and human epidermal growth factor receptor-2-negative(triple-negative) breast cancer [J]. Anti-cancer Drugs,2007,18(7): 835-837.
[23]
Xia W, Gerard CM, Liu L, et al. Combining lapatinib(GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells[J]. Oncogene,2005,24(41): 6213-6221.
[24]
Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer [J]. N Engl J Med,2006,355(26): 2733-2743.
[25]
Cameron D, Casey M, Press M, et al. A phase Ⅲrandomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses [J].Breast Cancer Res Treat,2008,112(3): 533-543.
[26]
Blackwell KL, Burstein HJ, Storniolo AM, et al. Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer [J]. J Clin Oncol,2010,28(7): 1124-1130.
[27]
Johnston S, Pippen J Jr, Pivot X, et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer [J]. J Clin Oncol,2009,27(33): 5538-5546.
[28]
Baselga J, Bradbury I, Eidtmann H, et al. Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial [J].Lancet,2012,379(9816): 633-640.
[29]
Untch M,Loibl S,Bischoff J,et al. Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy (GeparQuinto, GBG 44): a randomised phase 3 trial [J]. Lancet Oncol,2012,13(2): 135-144.
[30]
Rabindran SK, Discafani CM, Rosfjord EC, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase [J]. Cancer Res,2004,64(11): 3958-3965.
[31]
Burstein HJ,Sun Y,Dirix LY,et al. Neratinib,an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer [J]. J Clin Oncol,2010,28(8): 1301-1307.
[32]
Minkovsky N,Berezov A. BIBW-2992,a dual receptor tyrosine kinase inhibitor for the treatment of solid tumors [J]. Curr Opin Investig Drugs,2008,9(12): 1336-1346.
[33]
Lin NU, Winer EP, Wheatley D, et al. A phase Ⅱstudy of afatinib (BIBW2992), an irreversible ErbB family bloker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab [J]. Breast Cancer Res,2012,133(3): 1057-1065.
[34]
Miller TW, Rexer BN, Garrett JT, et al. Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer [J]. Breast Cancer Res,2011,13(6): 224.
[35]
Baselga J, Campone M, Piccart M, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer [J]. New Engl J Med,2012,366(6): 520-529.
[36]
Mackey JR, Kerbel RS, Gelmon KA, et al. Controlling angiogenesis in breast cancer: a systematic review of antiangiogenic trials [J]. Cancer Treat Rev,2012,38(6): 673-688.
[37]
Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer [J]. N Engl J Med,2007,357(26): 2666-2676.
[38]
Gray R, Bhattacharya S, Bowden C, et al. Independent review of E2100: a phase Ⅲtrial of bevacizumab plus paclitaxel versus paclitaxel in women with metastatic breast cancer [J]. J Clin Oncol,2009,27(30): 4966-4972.
[39]
Miles DW, Chan A, Dirix LY, et al. Phase Ⅲ study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer [J]. J Clin Oncol,2010,28(20): 3239-3247.
[40]
Robert NJ, Diéras V, Glaspy J, et al. RIBBON-1: randomized, doubleblind, placebo-controlled, phase Ⅲtrial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative,locally recurrent or metastatic breast cancer [J]. J Clin Oncol,2011,29(10): 1252-1260.
[41]
von Minckwitz G, Eidtmann H, Rezai M, et al. Neoadjuvant chemotherapy and bevacizumab for HER2-negative breast cancer [J]. N Engl J Med,2012,366(4): 299-309.
[42]
Bear HD, Tang G, Rastogi P, et al. Bevacizumab added to neoadjuvant chemotherapy for breast cancer [J]. N Engl J Med,2012,366(4): 310-320.
[43]
Ranpura V, Hapani S, Wu S. Treatment-related mortality with bevacizumab in cancer patients: a meta-analysis[J]. JAMA,2011,305(5): 487-494.
[44]
王涛,江泽飞.乳腺癌分子靶向治疗进展、困境和出路[J/CD].中华乳腺病杂志: 电子版,2011,5(5): 517-524.
[45]
Robert NJ, Saleh MN, Paul D, et al. Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advancedbreast cancer: a phase Ⅲ, randomized,open-label trial [J]. Clin Breast Cancer,2011,11(2): 82-92.
[46]
Burstein HJ, Elias AD, Rugo HS, et al. Phase Ⅱstudy of sunitinib malate,an oral multitargeted tyrosine kinase inhibitor,in patients with metastatic breast cancer previously treated with an anthracycline and a taxane [J]. J Clin Oncol,2008,26(11): 1810-1816.
[47]
Baselga J,Segalla JG, Roché H, et al. Sorafenib in combination with capecitabine: an oral regimen for patients with HER2-negative locally advanced or metastatic breast cancer [J]. J Clin Oncol,2012,30(13): 1484-1491.
[48]
Erlichman C. Tanespimycin: the opportunities and challenges of targeting heat shock protein 90 [J]. Expert Opin Investig Drugs,2008,18(6): 861-868.
[49]
Modi S, Stopeck A, Linden H, et al. HSP90 inhibition is effective in breast cancer: a phase Ⅱtrial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab [J]. Clin Cancer Res,2011,17(15): 5132-5139.
[50]
Glendenning J, Tutt A. PARP inhibitors-current status and the walk towards early breast cancer [J]. Breast,2011,20(Suppl 3): S9-S12.
[51]
Wicki A, Rochlitz C. Targeted therapies in breast cancer [J].Swiss Med Wkly,2012,142: w13 550.
[52]
Tryfonopoulos D, Walsh S, Collins DM, et al. Scr: a potential target for the treatment of triple-negative breast cancer [J].Ann Oncol,2011,22(10): 2234-2240.
[53]
Herold CI, Chadaram V, Peterson BL, et al. Phase Ⅱtrial of dasatinib in patients with metastatic breast cancer using realtime pharmacodynamic tissue biomarkers of Src inhibition to escalate dosing[J]. Clin Cancer Res,2011,17(18): 6061-6070.
[54]
Somlo G, Atzori F, Strauss LC, et al. Dasatinib plus capecitabine for advanced breast cancer: safety and efficacy in phaseⅠstudy CA180004 [J]. Clin Cancer Res,2013,19(7): 1884-1893.
[55]
Peoples GE, Holmes JP, Hueman MT, et al. Combined clinical trial results of a HER2/neu (E75) vaccine for the prevention of recurrence in high-risk breast cancer patients: U.S.Military Cancer Institute Clinical Trials Group Study I-01 and I-02[J]. Clin Cancer Res,2008,14(3): 797-803.
[56]
Morse MA, Hobeika A,Osada T,et al. Long term disease-free survival and T cell and antibody responses in women with highrisk HER2+ breast cancer following vaccination against Her2[J]. J Transl Med,2007,5: 42.
[1] 李洋, 蔡金玉, 党晓智, 常婉英, 巨艳, 高毅, 宋宏萍. 基于深度学习的乳腺超声应变弹性图像生成模型的应用研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 563-570.
[2] 河北省抗癌协会乳腺癌专业委员会护理协作组. 乳腺癌中心静脉通路护理管理专家共识[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 321-329.
[3] 刘晨鹭, 刘洁, 张帆, 严彩英, 陈倩, 陈双庆. 增强MRI 影像组学特征生境分析在预测乳腺癌HER-2 表达状态中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 339-345.
[4] 张晓宇, 殷雨来, 张银旭. 阿帕替尼联合新辅助化疗对三阴性乳腺癌的疗效及预后分析[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 346-352.
[5] 邱琳, 刘锦辉, 组木热提·吐尔洪, 马悦心, 冷晓玲. 超声影像组学对致密型乳腺背景中非肿块型乳腺癌的诊断价值[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 353-360.
[6] 程燕妮, 樊菁, 肖瑶, 舒瑞, 明昊, 党晓智, 宋宏萍. 乳腺组织定位标记夹的应用与进展[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 361-365.
[7] 涂盛楠, 胡芬, 张娟, 蔡海峰, 杨俊泉. 天然植物提取物在乳腺癌治疗中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 366-370.
[8] 朱文婷, 顾鹏, 孙星. 非酒精性脂肪性肝病对乳腺癌发生发展及治疗的影响[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 371-375.
[9] 周荷妹, 金杰, 叶建东, 夏之一, 王进进, 丁宁. 罕见成人肋骨郎格汉斯细胞组织细胞增生症被误诊为乳腺癌术后骨转移一例[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 380-383.
[10] 葛睿, 陈飞, 李杰, 李娟娟, 陈涵. 多基因检测在早期乳腺癌辅助治疗中的应用价值[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(05): 257-263.
[11] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[12] 韩萌萌, 冯雪园, 马宁. 乳腺癌改良根治术后桡神经损伤1例[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 117-118.
[13] 张志兆, 王睿, 郜苹苹, 王成方, 王成, 齐晓伟. DNMT3B与乳腺癌预后的关系及其生物学机制[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 624-629.
[14] 王玲艳, 高春晖, 冯雪园, 崔鑫淼, 刘欢, 赵文明, 张金库. 循环肿瘤细胞在乳腺癌新辅助及术后辅助治疗中的应用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 630-633.
[15] 赵林娟, 吕婕, 王文胜, 马德茂, 侯涛. 超声引导下染色剂标记切缘的梭柱型和圆柱型保乳区段切除术的效果研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 634-637.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?