Currently, surgical resection remains the primary local treatment for breast cancer. However, some breast cancer patients are unable to undergo or refuse surgical resection due to multiple comorbidities, advanced age, locally advanced disease, or fear of recurrence. Lack of treatment for the local breast cancer leads to a high risk of both uncontrolled local progression and distant metastasis. Image-guided ablation therapy demonstrates advantages such as minimal invasiveness, high tolerability, precise tumor inactivation, repeatability for recurrent tumors, excellent cosmetic outcomes without scars, and preservation of glandular structure and function. Compared with surgery, ablation therapy has achieved similar clinical efficacy in early stage solid tumors. In recent years, the application of ablation therapy in breast cancer has been steadily increasing. Based on the latest research progress and China's clinical practice, the expert consensus standardizes treatment protocols and procedures of ablation therapy, in order to enhance the safety and efficacy of ablation therapy for non-surgical breast cancer candidates.