Home    中文  
 
  • Search
  • lucene Search
  • Citation
  • Fig/Tab
  • Adv Search
Just Accepted  |  Current Issue  |  Archive  |  Featured Articles  |  Most Read  |  Most Download  |  Most Cited

Chinese Journal of Breast Disease(Electronic Edition) ›› 2025, Vol. 19 ›› Issue (02): 70-75. doi: 10.3877/cma.j.issn.1674-0807.2025.02.002

• Forum of Specialists • Previous Articles     Next Articles

Clinical insights on HER-2-low and HER-2-ultralow in breast cancer

Jinze Li1, Yaqi Peng2, Yueping Liu1, Li Ma3,()   

  1. 1. Department of Pathology,Fourth Hospital of Hebei Medical University, Shijiazhuang 050035, China
    2. Department of Clinical Medicine, College of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China
    3. Breast Disease Center, Fourth Hospital of Hebei Medical University, Shijiazhuang 050035, China
  • Received:2024-10-22 Online:2025-04-01 Published:2025-05-19
  • Contact: Li Ma

Abstract:

The key to successful treatment of breast cancer lies in the prompt diagnosis and effective therapeutic strategies. HER-2 plays a pivotal role in the biological behavior and pathogenesis of breast cancer,exerting significant influence on its progression and development. The development of novel antibody-drug conjugates (ADC) has disrupted the situation where traditional anti-HER-2 targeted therapy relied on receptor expression or gene amplification, bringing HER-2-low and HER-2-ultralow subtypes of breast cancer increasingly into the public view. This has sparked a renewed research focus and inaugurated a new era in the treatment of breast cancer. This article aims to provide a comprehensive review from clinical and pathological perspectives regarding the necessity of detecting HER-2-low and HER-2-ultralow expression in breast cancer,detection methods, as well as the factors influencing the precise detection of HER-2-low and HER-2-ultralow subtypes.

Key words: Breast neoplasms, Receptor, ErbB-2, Targeted therapy

京ICP 备07035254号-13
Copyright © Chinese Journal of Breast Disease(Electronic Edition), All Rights Reserved.
Tel: 0086-10-51322630 E-mail: jcbd@medmail.com.cn
Powered by Beijing Magtech Co. Ltd