Study on the expression of clusterin and the relationship between clusterin and Bax in infiltrating ductal carcinoma of the breast

doi:10.3877/cma.j.issn.1674-0807.2007.03.014

Abstract

Abstract:

Objective

To investigate the expression and significance of clusterin（a newly discovered antipoptosis protein，which is overexpressed in many cancers and plays an important role in the development of cancer）in infiltrating ductal carcinoma of the breast.

Methods

The expressions of clusterin and Bax in infiltrating ductal carcinoma of the breast were examined by immunohistochemical S-P method.

Results

The expression of clusterin was negative in normal breast tissues.The overexpression rate of clusterin in infiltrating ductal carcinoma of the breast was 62.79%（27/43）.The expression level of clusterin in infiltrating ductal carcinoma of the breast was not related to age and mentopausal state，but was related positively with pathological differentiation（r=0.3799，P=0.0266），clinical stage（r=0.3206，P=0.0356）and lymph node metastasis（r=0.5937，P=0.0005）.The expression level of clusterin in infitrating ductal carcinoma of the breast had a negative correlation with Bax（r=-0.3273，P﹤0.05），ER（r=-0.3038，P﹤0.05）and PR expression（r=-0.3451，P﹤0.05），and had no correlation with HER-2（r=0.2644，P﹥0.05）.

Conclusion

Clusterin may play an important role in the carcinogenesis and development of infiltrating breast carcinoma.

Key words: Breast neoplasms, Immunohistochemistry, Clusterin, Bax

Jia-lan ZANG, Chun-hong LI, Hong-yan CAO, Li CAI. Study on the expression of clusterin and the relationship between clusterin and Bax in infiltrating ductal carcinoma of the breast[J]. Chinese Journal of Breast Disease(Electronic Edition), 2007, 01(03): 44-47.

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URL: https://zhrxbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0807.2007.03.014

https://zhrxbzz.cma-cmc.com.cn/EN/Y2007/V01/I03/44

Figures/Tables 1

References 12

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临床因素	聚集素
临床因素	阳性例数	阴性例数	χ ²值	P值
Bax状态			4.605 1	0.031 9
Bax+	13	13
Bax-	14	3
雌激素受体			6.234 4	0.012 5
ER+	8	11
ER-	19	5
激素受体			5.121 2	0.023 6
PR+	6	9
PR-	21	7
HER-2			1.866 1	0.171 9
HER-2+	10	2
HER-2-	17	14
肿瘤分期			4.418 4	0.035 6
Ⅰ+Ⅱ	23	9
Ⅲ+Ⅳ	4	7
腋窝淋巴结状态			12.250 1	0.000 5
N₀	25	6
N₁	2	10
肿瘤分化程度			7.254 6	0.026 6
高	4	8
中	9	5
低	14	3
肿瘤大小			4.374 9	0.036 5
﹤2cm	10	12
≥2cm	17	4
年龄			0.002 0	0.964 6
﹤50	15	9
≥50	12	7
月经状况			0.731 7	0.392 3
绝经前	15	11
绝经后	12	5

临床因素	聚集素
临床因素	阳性例数	阴性例数	χ ²值	P值
Bax状态			4.605 1	0.031 9
Bax+	13	13
Bax-	14	3
雌激素受体			6.234 4	0.012 5
ER+	8	11
ER-	19	5
激素受体			5.121 2	0.023 6
PR+	6	9
PR-	21	7
HER-2			1.866 1	0.171 9
HER-2+	10	2
HER-2-	17	14
肿瘤分期			4.418 4	0.035 6
Ⅰ+Ⅱ	23	9
Ⅲ+Ⅳ	4	7
腋窝淋巴结状态			12.250 1	0.000 5
N₀	25	6
N₁	2	10
肿瘤分化程度			7.254 6	0.026 6
高	4	8
中	9	5
低	14	3
肿瘤大小			4.374 9	0.036 5
﹤2cm	10	12
≥2cm	17	4
年龄			0.002 0	0.964 6
﹤50	15	9
≥50	12	7
月经状况			0.731 7	0.392 3
绝经前	15	11
绝经后	12	5

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