Comparative study of preoperative and postoperative occult tumor cells in peripheral blood of breast cancer patients undergoing E-ALND and ALND

doi:10.3877/cma.j.issn.1674-0807.2007.03.011

Abstract

Abstract:

Objective

To evaluate the safety of endoscopic axillay lymph node dissection（E-ALND）by liposuction.

Methods

Sixty-four cases of breast cancer were divided into an E-ALND group and a traditional ALND group，32 cases in each group.CK-19 mRNA copy numbers in peripheral blood were detected with SYBR Green I real time polymerase chain reaction before and after operation.

Results

The positive expression rate of CK-19 mRNA was 32.81%in peripheral blood in the 64 patients，and 31.25%and 34.38%in the E-ALND group and the ALND group，respectively.The likelihood of hemotogenous dissemination of tumor cells was 4.34%and 8.70%in the E-ALND group and the ALND group，respectively；OTC（occult tumor cell）in peripheral blood of patients who underwent preoperative chemotherapy could still be detected，and increased with the upgrading of breast cancer stage.

Conclusions

There is no difference in hemotogenous dissemination of tumor cells in breast cancer between E-ALND and traditional ALND.Compared with the ALND group，the likelihood of hemotogenous dissemination of tumor cells does not increase in the E-ALND group.

Key words: Endoscopy, Breast neoplasms, Axillary lymph node dissection, Occult tumor cell

Mei-qin GUO, Jun JIANG, Lin-jun FAN, Xin-hua YANG. Comparative study of preoperative and postoperative occult tumor cells in peripheral blood of breast cancer patients undergoing E-ALND and ALND[J]. Chinese Journal of Breast Disease(Electronic Edition), 2007, 01(03): 36-39.

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Figures/Tables 3

References 6

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临床资料	腔镜手术组（例）	传统手术组（例）	χ ²值	P值
例数	32	32
肿瘤分期			3.388	0.184
Ⅰ期	15	8
Ⅱ期	14	19
Ⅲ期	3	5
手术方式			5.600	0.067
MRM^a	20	28
BCT^b	8	2
NS-MRM^c	4	2
肿瘤类型^d			0.504	0.777
浸润性导管癌	26	24
浸润性小叶癌	5	6
内分泌癌	1	0
鳞状细胞癌	0	2

临床资料	腔镜手术组（例）	传统手术组（例）	χ ²值	P值
例数	32	32
肿瘤分期			3.388	0.184
Ⅰ期	15	8
Ⅱ期	14	19
Ⅲ期	3	5
手术方式			5.600	0.067
MRM^a	20	28
BCT^b	8	2
NS-MRM^c	4	2
肿瘤类型^d			0.504	0.777
浸润性导管癌	26	24
浸润性小叶癌	5	6
内分泌癌	1	0
鳞状细胞癌	0	2

术后	腔镜手术组（术前）		传统手术组（术前）
术后	OTC（+）	OTC（-）	OTC（+）	OTC（-）
OTC（+）	6	1	3	2
OTC（-）	3	20	6	21

术后	腔镜手术组（术前）		传统手术组（术前）
术后	OTC（+）	OTC（-）	OTC（+）	OTC（-）
OTC（+）	6	1	3	2
OTC（-）	3	20	6	21

分期	腔镜手术组				传统手术组
分期	阳性例数	阴性例数	χ ²值	P值	阳性例数	阴性例数	χ ²值	P值
Ⅰ期	2	13			1	7
Ⅱ期	6	8			6	13
Ⅲ期	2	1	10.68	0.005	4	1	6.45	0.04

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