Adipocytes associated with breast cancer

doi:10.3877/cma.j.issn.1674-0807.2019.06.001

Abstract

Abstract:

Adipose tissue is an important component of the breast. Breast cancer-associated adipocytes are active facilitators, not silent bystanders, in the development of cancer, providing metabolic substrates for tumor cells and mediating resistance to treatment. At the same time, cancer-associated adipocytes are also affected by endocrine and paracrine signals from breast cancer cells. They form the crown-like structure with macrophages, enhance lipolysis, release free fatty acids, and secret all kinds of adipocytokines, including leptin, adiponectin, interleukin-8, and so on. Through these mechanisms, cancer-associated adipocytes remodel the metabolic process, and promote the occurrence, proliferation, invasion and metastasis of breast cancer cells. With the deepening of research, cancer-associated adipocytes will become an important target for the precision treatment of breast cancer.

Key words: Breast neoplasms, Leptin, Adiponectin, Interleukin-8, Cancer-associated adipocytes

Jinli Wei, Zhimin Shao. Adipocytes associated with breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2019, 13(06): 321-325.

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