Abstract:

Objective

To explore the relation between the pathological results and clinical data in 85 cases of white nipple discharge from single breast duct.

Methods

Retrospective analysis of the relation between the pathological results and clinical data in 85 cases of white nipple discharge from single breast duct treated in our hospital from June 2004 to May 2009.Chi-square test or continuity correction chi-square was used for statistical analysis.

Results

Of the 85 cases，12 had breast cancer， occupying 14.12%.In the 12 breast cancer cases， patients aged ＞50 years were more than those aged ≤50 （χ² =14.43，P=0.00）， perimenopausal patients were more than non-menopausal ones （χ² =33.27，P=0.00）， patients with disease course ＞12 months were more than those≤12 months（χ²=8.89，P=0.00），patients with intraductal lesion＞2 cm from the nipple were more than those ≤2 cm from the nipple（χ²=24.04，P=0.00）， patients with mass were more than those without mass（χ²=20.64，P=0.00）， but patients with nipple discharge of the left breast had no statistical difference with those with nipple discharge of the right breast（χ²=0.00，P=0.76）.The sensitivity of fiberoptic ductoscopy（FDS） was 83.33% （10/12）.

Conclusions

Breast cancer can occur in white nipple discharge from single breast duct.Patients with age ＞50 years， postmenopause， disease course ＞12 months and intraductal lesion ＞2 cm from the nipple are common， and most patients have mass.So enough attention should be given.The diagnoses accordance rate of FDS for breast cancer is high in white nipple discharge from single breast duct.

Key words: single-duct nipple discharge, breast neoplasms, endoscopy