Abstract:
Objective
To investigate theinfluence of parecoxib on analgesic effect and stress responsein breast cancer patients treated with modified radical mastectomy.
Methods
According to American Society of Anesthesiologists(ASA)grade,60 breast cancer patients with ASAⅠorⅡundergoing modified radical mastectomy were selected and randomly divided into 2 groups:the parecoxib group(n=30)and the control group(n=30).All patients received intravenous analgesia(PCIA)with butorphanol.In the parecoxib group,40 mg parecoxib was ad ministered at the end of the surgery and 12 h,24 h and 36 h after surgery.The control group received iv saline 5 ml at the same ti me points.Renin activity,angiotensinⅡ,aldosterone and cortisol in plas ma in each group were measured i mmediately before induction of anesthesia(T0)and 2 h(T1),12 h(T2),24 h(T3)and 48 h(T4)after operation.The analgesic effect assessed by visual analog scale(VAS)at T1,T2,T3 and T4.Repeated measures analysis of variance and t test were used for statistical analysis.
Results
The VAS pain scores in the parecoxib group were significantly lower than those in the control group at T2,T3 and T4,respectively(P＜0.05).There was no significant difference in the concentrations of plas ma renin activity,angiotensinⅡ,aldosterone and cortisol at T2,T3,and T4 compared to T0 in the parecoxib group(P＞0.05),while the concentrations of plasma renin activity,angiotensinⅡ,aldosterone and cortisol at T2,T3 were significantly increased compared to T0 in the control group (P＜0.05).The concentrations of plas ma renin activity,angiotensinⅡ,aldosterone and cortisol at T2 and T3 were significantly lower in the parecoxib group than in the control group,with statistical difference bet ween the t wo groups (P＜0.05).
Conclusion
Parecoxib has a good postoperation analgesic effect,and can effectively prevent stress response.It is useful in relieving postoperative i mmunolesion and inflammatory reaction for breast cancer patients with radical excision of breast cancer.
Key words:
Breast neoplasms,
Modified radical mastectomy,
Parecoxib,
Analgesia,
Stress
Bin LI, Jian-hua LI, Hui-ying HU, Lei CHENG. Influence of parecoxib on analgesic effect and stress responsein patients after radical excision of breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2010, 04(02): 144-148.