Abstract:

Objective

To identify related risk factors of thrombosis caused by subclavian vein catheterization for chemotherapy after breast cancer surgery.

Methods

The clinical data of 1280 patients from our hospital were collected and analyzed.All patients were pathologically confirmed as breast cancer and surgically managed,and subsequently had chemotherapy through subclavian vein catheterization.Logistic regression model was used for analysis of related factors of thrombosis.

Results

Univariate Logistic analyses of potential risk factors showed that old age,breast cancer with diabetes,high plasma fibrinogen concentration,puncture site infection,repeated puncture at the same site,an inadequate position for the subclavian vein catheter tip,subclavian vein puncture path and chemotherapy regimens with vinorelbine were significant variables affecting thrombus formation(P＜0.050).Multivariant logistic analysis showed that breast cancer with diabetes,high plasma fibrinogen concentration,puncture site infection,repeated puncture at the same site,inadequate position for subclavian vein catheter and chemotherapy regimens with vinorelbine were major risk factors(P＜0.050).

Conclusions

Breast cancer with diabetes,higher plasma fibrinogen concentration,puncture site infection,repeated puncturate at the same site,an inadequate position for subclavian vein catheterizaer tip and chemotherapy regimens with vinorelbine are risk factors of thrombus formation.We should pay great attention and carry out appropriate treatment to decrease thrombus incidence for these patients,and let the subclavian vein catheterization be well used.

Key words: Breast neoplasms, Subclavian vein catheterization, Thrombosis