Clinical value of diffused optical tomography with ultrasound in the diagnosis of breast cancer

doi:10.3877/cma.j.issn.1674-0807.2009.04.005

Abstract

Abstract:

Objective

To study the value of diffused optical breast imaging with ultrasound(OPTIMUS^®,OPTIMUS system)in the diagnosis of breast tumors.

Methods

The images of 136 breast tumors by OPTIMUS system were reviewed and compared with pathological results.Meanwhile ultrasound and X-ray examinations were performed.Consistency checking was used to evaluate the consistency of pathological, ultrasound and X-ray examinations. The receiver operating characteristic(ROC)curve was done to calculate the area under the curve to evaluate the accuracy of OPTIMUS system and the clinical value of OPTIMUS system in the diagnosis of breast cancer.

Results

In the 136 cases,pathological diagnosis showed 50 cases were benign and 86 cases malignant.OPTIMUS system diagnosis showed 34 cases were benign and 102 cases malignant;among the 102 cases,16 were overdiagnosed as cancer.Bases on the pathological results,the consistency checking Kappa value was 0.536 and 0.386 for ultrasound and X-ray examinations respectively,and 0.729,0.616,and 0.649 for OPTIMUS system,ultrasound and Xray examinations respectively.The area under ROC for OPTIMUS system,ultrasound and X-ray examinations was 0.840(95%CI 0.758-0.922),0.817(95%CI 0.739-0.895)and 0.837(95%CI 0.763-0.910)respectively.

Conclusion

OPTIMUS system is a non-invasive and highly effective diagnostic tool for breast disease and it could be used as assistant diagnostic tool for breast tumors.

Key words: Diffused optical tomography with ultrasound, Breast tumor, Ultrasonography, Mammography

Yue LI, Ying ZHAO, Bin ZHANG, Jie GE, Lian-sheng NING, Xuchen CAO, Zhi-hao YU, Xin WANG. Clinical value of diffused optical tomography with ultrasound in the diagnosis of breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2009, 03(04): 398-405.

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URL: https://zhrxbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0807.2009.04.005

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Figures/Tables 10

References 21

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BI-RADS分级	解释
0	不能评价——无法做出判断,需要结合其他的影像学诊断工具
1	阴性——阴性,未发现异常
2	良性——符合良性特征,未见恶性特征
3	可疑良性——恶性可能较小需要短期6月的跟踪检查
4	可疑恶性——可能是癌,建议取样检查
4A	怀疑度低——肿物有较低的可能是恶性,建议针吸检查或活检
4B	怀疑度中等——肿物有中等程度的可能是恶性,建议活检
4C	怀疑度较高——肿物有较高的可能是恶性,建议活检
5	高度可疑恶性——疑肿物具有高度的可能是恶性,应当采取适当的措施

BI-RADS分级	解释
0	不能评价——无法做出判断,需要结合其他的影像学诊断工具
1	阴性——阴性,未发现异常
2	良性——符合良性特征,未见恶性特征
3	可疑良性——恶性可能较小需要短期6月的跟踪检查
4	可疑恶性——可能是癌,建议取样检查
4A	怀疑度低——肿物有较低的可能是恶性,建议针吸检查或活检
4B	怀疑度中等——肿物有中等程度的可能是恶性,建议活检
4C	怀疑度较高——肿物有较高的可能是恶性,建议活检
5	高度可疑恶性——疑肿物具有高度的可能是恶性,应当采取适当的措施

超声检查	病理检查		合计
超声检查	恶性	良性	合计
恶性	70	9	79
良性	16	41	57
合计	86	50	136

超声检查	病理检查		合计
超声检查	恶性	良性	合计
恶性	70	9	79
良性	16	41	57
合计	86	50	136

钼靶X线检查	病理检查		合计
钼靶X线检查	恶性	良性	合计
恶性	70	7	77
良性	16	43	59
合计	86	50	136

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