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Chinese Journal of Breast Disease(Electronic Edition) ›› 2008, Vol. 02 ›› Issue (02): 22-24. doi: 10.3877/cma.j.issn.1674-0807.2008.02.006

• Experimental Research • Previous Articles     Next Articles

Association between TNFR II gene polymorphisms and breast cancer

Xiao-yi LIU1, Jian-xia HU1, Yu WANG1, Mingzhi CAO,1()   

  1. 1.Department of Galactophore, Qingdao Medical School Hospital, Qingdao 266003, China
  • Received:2008-01-10 Online:2008-04-01 Published:2024-12-06
  • Contact: Mingzhi CAO

Abstract:

Objective

To explore the relationship between TNF-α receptor II(TNFR II)gene -196M/R polymorphisms and breast cancer.

Methods

TNFR II gene polymorphisms at position -196 were determined by polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) method in 212 female patients with breast cancer,218 female patients with breast benign diseases and 220 female healthy controls.

Results

(1)There were TNFR II gene -196 M/R polymorphisms in the 640 cases. (2) There was no statistic difference in the frequencies of TG+GG genotype and allele G between benign and control groups. The frequencies of TG+GG genotype in the study group were significantly higher than those in the benign and control groups (P <0.05).

Conclusion

There were TNFR II gene -196 M/R polymorphisms in breast cancer and control groups.TNFR II gene -196 G allele may be the predisposing gene and the relative risk of breast cancer.

Key words: Breast carcinoma, TNF- α, TNF- α receptor II (TNFR II), Polymorphisms

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