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中华乳腺病杂志(电子版) ›› 2026, Vol. 20 ›› Issue (01) : 49 -54. doi: 10.3877/cma.j.issn.1674-0807.2026.01.007

综述

肿瘤浸润淋巴细胞在乳腺癌免疫治疗中的作用及其预后预测价值
栗家兴, 程紫轩, 吕欣悦, 王江芬, 张晶晶, 张亚芬()   
  1. 030000 太原,山西医科大学第五临床医学院/山西省人民医院乳腺外科
  • 收稿日期:2025-05-12 出版日期:2026-02-01
  • 通信作者: 张亚芬
  • 基金资助:
    山西省自然科学基金项目(202403021221281)

Role oftumor-infiltrating lymphocytes in breast cancer immunotherapy andtheir prognostic value

Jiaxing LI, Zixuan CHENG, Xinyue LYU   

  • Received:2025-05-12 Published:2026-02-01
引用本文:

栗家兴, 程紫轩, 吕欣悦, 王江芬, 张晶晶, 张亚芬. 肿瘤浸润淋巴细胞在乳腺癌免疫治疗中的作用及其预后预测价值[J/OL]. 中华乳腺病杂志(电子版), 2026, 20(01): 49-54.

Jiaxing LI, Zixuan CHENG, Xinyue LYU. Role oftumor-infiltrating lymphocytes in breast cancer immunotherapy andtheir prognostic value[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2026, 20(01): 49-54.

乳腺癌是全球女性发病率和死亡率均居前列的恶性肿瘤,其治疗的异质性与预后预测的复杂性均是临床研究的核心挑战。近年来,肿瘤浸润淋巴细胞(TIL)作为一种新兴的生物标志物,在乳腺癌的精准分层与治疗中展示出重要价值。笔者围绕乳腺癌精准诊疗中的关键问题,系统探讨TIL在患者分层、预后预测和免疫治疗优化中的作用,重点分析TIL在不同乳腺癌分子亚型中的浸润特征与功能差异,评估其作为预后和免疫反应预测标志物的潜力;同时对比多种评估方法的优缺点,并展望过继TIL治疗的临床应用前景。期望为乳腺癌的个体化免疫治疗提供参考,推动TIL在临床实践中的规范化应用。

图1 乳腺癌肿瘤微环境免疫生态图 注:TLS为三级淋巴结构;CTL为细胞毒性T淋巴细胞;CD为白细胞分化抗原;INF-γ为干扰素γ;IL-10为白细胞介素10;TGF-β为转化生长因子-β
表1 乳腺癌中TIL不同检测方法比较
表2 TIL在乳腺癌及其他癌症免疫治疗中的研究
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