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中华乳腺病杂志(电子版) ›› 2025, Vol. 19 ›› Issue (01) : 58 -60. doi: 10.3877/cma.j.issn.1674-0807.2025.01.011

综述

吡咯替尼新辅助治疗HER-2 阳性乳腺癌的研究现状
杨颖1, 辛岗2, 王丽君2, 胡崇珠1,()   
  1. 1.071000 河北,保定市第一中心医院乳腺外一科
    2.067000 河北,承德医学院研究生学院
  • 收稿日期:2024-02-25 出版日期:2025-02-01
  • 通信作者: 胡崇珠

Pyrotinib neoadjuvant therapy for HER-2 positive breast cancer

Ying Yang, Gang Xin, Lijun Wang, Chongzhu Hu()   

  • Received:2024-02-25 Published:2025-02-01
  • Corresponding author: Chongzhu Hu
引用本文:

杨颖, 辛岗, 王丽君, 胡崇珠. 吡咯替尼新辅助治疗HER-2 阳性乳腺癌的研究现状[J/OL]. 中华乳腺病杂志(电子版), 2025, 19(01): 58-60.

Ying Yang, Gang Xin, Lijun Wang, Chongzhu Hu. Pyrotinib neoadjuvant therapy for HER-2 positive breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2025, 19(01): 58-60.

吡咯替尼是中国自主研发的泛ErbB 酪氨酸激酶抑制剂,其在HER-2 阳性乳腺癌新辅助治疗中的疗效逐渐受到关注。 现有研究表明,基于吡咯替尼联合曲妥珠单克隆抗体(HPy)的新辅助治疗方案具有良好的客观缓解率和病理完全缓解率,在某些研究中优于基于曲妥珠单克隆抗体联合帕妥珠单克隆抗体(HP)的方案。 然而,吡咯替尼相关研究样本量有限,缺乏长期生存数据,且有较高的腹泻发生率。 当前尚无高质量临床研究直接比较HPy 方案与HP 方案的疗效和安全性。 本文就吡咯替尼新辅助治疗HER-2 阳性乳腺癌的疗效、安全性和疗效预测因子等方面的内容进行综述。

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