| [1] |
IARC. Global cancer burden growing, amidst mounting need for services [M]. Lyon：International Agency for Research on Cancer，2024.
|
| [2] |
Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024，74(3)：229-263.
|
| [3] |
Harbeck N, Penault-Llorca F, Cortes J, et al. Breast cancer[J]. Nat Rev Dis Primers，2019，5(1)：66.
|
| [4] |
Davalos V, Esteller M. Cancer epigenetics in clinical practice[J]. CA Cancer J Clin，2023，73(4)：376-424.
|
| [5] |
Zhang D, Tang Z, Huang H, et al. Metabolic regulation of gene expression by histone lactylation[J]. Nature，2019，574(7779)：575-580.
|
| [6] |
Millan-Zambrano G, Burton A, Bannister AJ, et al. Histone post-translational modifications - cause and consequence of genome function[J]. Nat Rev Genet，2022，23(9)：563-580.
|
| [7] |
Wang N, Wang W, Wang X, et al. Histone lactylation boosts reparative gene activation post-myocardial infarction[J]. Circ Res，2022，131(11)：893-908.
|
| [8] |
Moreno-Yruela C, Baek M, Monda F, et al. Chiral posttranslational modification to lysine epsilon-amino groups[J]. Acc Chem Res，2022，55(10)：1456-1466.
|
| [9] |
Yang Z, Yan C, Ma J, et al. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma[J]. Nat Metab，2023，5(1)：61-79.
|
| [10] |
Xie Y, Hu H, Liu M, et al. The role and mechanism of histone lactylation in health and diseases[J]. Front Genet，2022，13：949252.
|
| [11] |
Xu H, Wu M, Ma X, et al. Function and mechanism of novel histone posttranslational modifications in health and disease[J]. Biomed Res Int，2021，2021：6635225.
|
| [12] |
Li X, Yang Y, Zhang B, et al. Lactate metabolism in human health and disease[J]. Signal Transduct Target Ther，2022，7(1)：305.
|
| [13] |
Jiang P, Ning W, Shi Y, et al. FSL-Kla: a few-shot learning-based multi-feature hybrid system for lactylation site prediction[J]. Comput Struct Biotechnol J，2021，19：4497-4509.
|
| [14] |
Bhagat TD, Von Ahrens D, Dawlaty M, et al. Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts[J]. Elife，2019，8：e50663.
|
| [15] |
Sun K, Tang S, Hou Y, et al. Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling[J]. EBioMedicine，2019，41：370-383.
|
| [16] |
Qiu Z, Wang L, Liu H. Hsa_circ_0001982 promotes the progression of breast cancer through miR-1287-5p/MUC19 axis under hypoxia[J]. World J Surg Oncol，2021，19(1)：161.
|
| [17] |
Castagnoli L, Iorio E, Dugo M, et al. Intratumor lactate levels reflect HER2 addiction status in HER2-positive breast cancer[J]. J Cell Physiol，2019，234(2)：1768-1779.
|
| [18] |
Longhitano L, Forte S, Orlando L, et al. The crosstalk between GPR81/IGFBP6 promotes breast cancer progression by modulating lactate metabolism and oxidative stress[J]. Antioxidants (Basel)，2022，11(2)：275.
|
| [19] |
Brown TP, Bhattacharjee P, Ramachandran S, et al. The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment[J]. Oncogene，2020，39(16)：3292-3304.
|
| [20] |
Ishihara S, Hata K, Hirose K, et al. The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer[J]. Sci Rep，2022，12(1)：6261.
|
| [21] |
San-Millan I, Julian CG, Matarazzo C, et al. Is lactate an oncometabolite? Evidence supporting a role for lactate in the regulation of transcriptional activity of cancer-related genes in MCF7 breast cancer cells[J]. Front Oncol，2019，9：1536.
|
| [22] |
Yu J, Chai P, Xie M, et al. Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma[J]. Genome Biol，2021，22(1)：85.
|
| [23] |
Chen L, Huang L, Gu Y, et al. Lactate-lactylation hands between metabolic reprogramming and immunosuppression[J]. Int J Mol Sci，2022，23(19)：11943.
|
| [24] |
Xiong J, He J, Zhu J, et al. Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells[J]. Mol Cell，2022，82(9)：1660-1677.
|
| [25] |
Tian LR, Lin MZ, Zhong HH, et al. Nanodrug regulates lactic acid metabolism to reprogram the immunosuppressive tumor microenvironment for enhanced cancer immunotherapy[J]. Biomater Sci，2022，10(14)：3892-3900.
|
| [26] |
Brown TP, Ganapathy V. Lactate/GPR81 signaling and proton motive force in cancer: role in angiogenesis, immune escape, nutrition, and warburg phenomenon[J]. Pharmacol Ther，2020，206：107451.
|
| [27] |
Chen Y, Wu J, Zhai L, et al. Metabolic regulation of homologous recombination repair by MRE11 lactylation[J]. Cell，2024，187(2)：294-311.
|
| [28] |
Deng J, Liao X. Lysine lactylation (Kla) might be a novel therapeutic target for breast cancer[J]. BMC Med Genomics，2023，16(1)：283.
|
| [29] |
Liu X, Liu H, Zeng L, et al. BRCA1 overexpression attenuates breast cancer cell growth and migration by regulating the pyruvate kinase M2-mediated Warburg effect via the PI3K/AKT signaling pathway[J]. PeerJ，2022，10：e14052.
|
| [30] |
Jiang Y, Zhang M, Yu D, et al. CircRBM33 downregulation inhibits hypoxia-induced glycolysis and promotes apoptosis of breast cancer cells via a microRNA-542-3p/HIF-1α axis[J]. Cell Death Discovery，2022，8(1)：126.
|
| [31] |
Wang W, He X, Wang Y, et al. LINC01605 promotes aerobic glycolysis through lactate dehydrogenase a in triple-negative breast cancer[J]. Cancer Sci，2022，113(8)：2484-2495.
|
| [32] |
Zu Y, Chen XF, Li Q, et al. PGC-1alpha activates SIRT3 to modulate cell proliferation and glycolytic metabolism in breast cancer[J]. Neoplasma，2021，68(2)：352-361.
|
| [33] |
Zhou Y, Niu W, Luo Y, et al. p53/Lactate dehydrogenase a axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53[J]. Cancer Sci，2019，110(3)：939-949.
|
| [34] |
Jin J, Qiu S, Wang P, et al. Cardamonin inhibits breast cancer growth by repressing HIF-1alpha-dependent metabolic reprogramming[J]. J Exp Clin Cancer Res，2019，38(1)：377.
|
| [35] |
Pandkar MR, Sinha S, Samaiya A, et al. Oncometabolite lactate enhances breast cancer progression by orchestrating histone lactylation-dependent c-Myc expression[J]. Transl Oncol，2023，37：101758.
|
| [36] |
Zhao Y, Zhong R, Deng C, et al. Circle RNA circABCB10 modulates PFN2 to promote breast cancer progression, as well as aggravate radioresistance through facilitating glycolytic metabolism via miR-223-3p[J]. Cancer Biother Radiopharm，2021，36(6)：477-490.
|
| [37] |
Jin L, Guo Y, Chen J, et al. Lactate receptor HCAR1 regulates cell growth, metastasis and maintenance of cancer-specific energy metabolism in breast cancer cells[J]. Mol Med Rep，2022，26(2)：268.
|
| [38] |
Zong S, Dai W, Fang W, et al. SIK2 promotes cisplatin resistance induced by aerobic glycolysis in breast cancer cells through PI3K/AKT/mTOR signaling pathway[J]. Biosci Rep，2020：R20201302.
|
| [39] |
Li F, Zhang H, Huang Y, et al. Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer[J]. Drug Resist Updat，2024，73：101059.
|
| [40] |
Li W, Zhou C, Yu L, et al. Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer[J]. Autophagy，2024，20(1)：114-130.
|