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中华乳腺病杂志(电子版) ›› 2022, Vol. 16 ›› Issue (02) : 121 -124. doi: 10.3877/cma.j.issn.1674-0807.2022.02.010

病例报告

原发性及继发性乳腺血管肉瘤临床病理分析及分子学改变
赵莎1, 王聪1,(), 徐祎1, 潘贝晶1   
  1. 1. 210029 南京医科大学第一附属医院病理科
  • 收稿日期:2021-03-02 出版日期:2022-04-01
  • 通信作者: 王聪

Clinicopathological analysis and molecular changes of primary and secondary breast angiosarcoma

Sha Zhao1, Cong Wang1(), Yi Xu1   

  • Received:2021-03-02 Published:2022-04-01
  • Corresponding author: Cong Wang
引用本文:

赵莎, 王聪, 徐祎, 潘贝晶. 原发性及继发性乳腺血管肉瘤临床病理分析及分子学改变[J]. 中华乳腺病杂志(电子版), 2022, 16(02): 121-124.

Sha Zhao, Cong Wang, Yi Xu. Clinicopathological analysis and molecular changes of primary and secondary breast angiosarcoma[J]. Chinese Journal of Breast Disease(Electronic Edition), 2022, 16(02): 121-124.

图1 乳腺血管肉瘤的病理表现 a图可见相互吻合的血管腔(HE ×40);b图所示,吻合的血管腔穿插在乳腺间质和脂肪组织中(HE ×40);c图所示,衬覆于血管腔的内皮细胞核深染(HE ×100);d图所示,肿瘤细胞异型性稍增加,相互吻合的血管腔变小(HE ×100);e图可见内皮细胞簇及乳头结构,并可见坏死(HE ×100);f图所示,细胞核深染,核分裂象易见(HE ×200)
图2 乳腺血管肉瘤的免疫组织化学检测结果 a图所示肿瘤细胞CD31强阳性表达(EnVision ×100);b图所示肿瘤细胞ERG强阳性表达(EnVision ×200);c图所示肿瘤细胞C-myc呈阳性表达(EnVision ×200);d图所示肿瘤细胞伴高增殖活性,Ki-67表达为60%~80%(EnVision ×100)注:ERG为红细胞转化特异性转录因子相关基因
图3 乳腺血管肉瘤C-myc基因的FISH检测 a图所示肿瘤细胞C-myc基因扩增(FISH ×1 000);b图所示肿瘤细胞C-myc基因无扩增(FISH ×1 000)注:FISH为荧光原位杂交技术
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