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中华乳腺病杂志(电子版) ›› 2022, Vol. 16 ›› Issue (02) : 116 -120. doi: 10.3877/cma.j.issn.1674-0807.2022.02.009

综述

血小板衍生生长因子/血小板衍生生长因子受体信号通路在乳腺癌发生、发展中的作用
郑鲁丹1, 陈敏2, 张永渠3, 张国君3,()   
  1. 1. 361100 厦门大学医学院内分泌肿瘤精准诊治重点实验室;315000 中国科学院大学宁波华美医院乳腺外科
    2. 361100 厦门大学医学院内分泌肿瘤精准诊治重点实验室
    3. 361100 厦门大学医学院内分泌肿瘤精准诊治重点实验室;361100 厦门大学附属翔安医院肿瘤诊治中心与乳腺甲状腺外科
  • 收稿日期:2020-02-17 出版日期:2022-04-01
  • 通信作者: 张国君

Role of platelet­derived growth factor/platelet­derived growth factor receptor signaling pathway in oncogenesis and progression of breast cancer

Ludan Zheng1, Min Chen2, Yongqu Zhang3   

  • Received:2020-02-17 Published:2022-04-01
引用本文:

郑鲁丹, 陈敏, 张永渠, 张国君. 血小板衍生生长因子/血小板衍生生长因子受体信号通路在乳腺癌发生、发展中的作用[J]. 中华乳腺病杂志(电子版), 2022, 16(02): 116-120.

Ludan Zheng, Min Chen, Yongqu Zhang. Role of platelet­derived growth factor/platelet­derived growth factor receptor signaling pathway in oncogenesis and progression of breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2022, 16(02): 116-120.

PDGF/PDGFR信号通路在细胞增殖、血管生成和纤维化中起着重要的作用,被证实在脑胶质瘤、结直肠癌和乳腺癌等多种癌症中亦有促癌作用。其中血小板衍生生长因子(PDGF)-B/血小板衍生生长因子受体(PDGFR)-β与乳腺癌的发生、发展关系密切,在乳腺癌中的表达水平存在组织差异性,而且与雌激素水平和分子分型等有关。PDGF-B/PDGFR-β以自分泌或旁分泌环的形式作用于乳腺肿瘤细胞以及微环境中的基质细胞,除了促进乳腺癌细胞上皮间质转化、增殖和侵袭迁移以外,还能促进肿瘤血管生成。笔者就PDGF-B/PDGFR-β信号通路在乳腺癌发生、发展中的作用进行阐述,并探讨其作为乳腺癌潜在的治疗靶点,未来可能指导乳腺癌个体化治疗。

图1 PDGF/PDGFR信号转导通路注:PDGF为血小板衍生生长因子;PDGFR为血小板衍生生长因子受体;PI3K为磷酯酰肌醇-3激酶;PLC-γ为磷脂酶C-γ;Ras/MAPK为Ras/丝裂原活化蛋白激酶;JAK/STAT为Janus激酶/信号转导与转录激活因子
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