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中华乳腺病杂志(电子版) ›› 2020, Vol. 14 ›› Issue (06) : 366 -370. doi: 10.3877/cma.j.issn.1674-0807.2020.06.008

所属专题: 文献

综述

乳腺癌中乳头乳晕复合体受侵犯的相关预测因素
黄伟玲1, 李玺1,()   
  1. 1. 510630 广州,中山大学附属第三医院甲状腺乳腺外科
  • 收稿日期:2020-05-25 出版日期:2020-12-01
  • 通信作者: 李玺

Predictive factors of nipple-areola complex involvement in breast cancer

Weiling Huang1, Xi Li1()   

  • Received:2020-05-25 Published:2020-12-01
  • Corresponding author: Xi Li
引用本文:

黄伟玲, 李玺. 乳腺癌中乳头乳晕复合体受侵犯的相关预测因素[J/OL]. 中华乳腺病杂志(电子版), 2020, 14(06): 366-370.

Weiling Huang, Xi Li. Predictive factors of nipple-areola complex involvement in breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2020, 14(06): 366-370.

保留乳头乳晕的乳房切除术(NSM),是指完整切除乳腺腺体、活组织检查瘢痕及肿瘤表面的皮肤,保留乳头乳晕复合体(NAC)的一种手术方式。其中,NAC的侵犯与否是进行NSM的决定性条件。目前许多研究对于NAC侵犯的相关因素进行了分析报道,但缺乏一致性和全面性。笔者综合阐述了NAC侵犯率、与NAC侵犯相关的肿瘤临床病理因素,如肿瘤位置、肿瘤大小、肿瘤-乳头距离、肿瘤类型、多中心性、淋巴结受累和HER-2高表达等,以及乳头下方活组织检查的重要性。选择NSM患者时,应对预测NAC侵犯的因素进行全面考虑,并结合术前NAC下方组织微创旋切活组织检查或术中冰冻病理结果,以决定是否保留NAC,这对NSM安全完成将会有很大的帮助。

表1 各文献报道中NAC侵犯率及相关因素
表2 各文献报道中TND临界值的设定及统计学差异
表3 各文献报道中肿瘤大小临界值的设定及统计学差异
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