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中华乳腺病杂志(电子版) ›› 2020, Vol. 14 ›› Issue (06) : 361 -365. doi: 10.3877/cma.j.issn.1674-0807.2020.06.007

所属专题: 文献

论著

头皮冷却疗法治疗女性乳腺癌患者化疗脱发的效果
王宁1,()   
  1. 1. 110022 沈阳,中国医科大学附属盛京医院乳腺外科
  • 收稿日期:2018-05-21 出版日期:2020-12-01
  • 通信作者: 王宁

Effect of scalp cooling therapy on alopecia caused by chemotherapy in breast cancer patients

Ning Wang1,()   

  1. 1. Department of Breast Surgery, Shengjing Hospital of China Medical University, Shengyang 110022, China
  • Received:2018-05-21 Published:2020-12-01
  • Corresponding author: Ning Wang
引用本文:

王宁. 头皮冷却疗法治疗女性乳腺癌患者化疗脱发的效果[J/OL]. 中华乳腺病杂志(电子版), 2020, 14(06): 361-365.

Ning Wang. Effect of scalp cooling therapy on alopecia caused by chemotherapy in breast cancer patients[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2020, 14(06): 361-365.

目的

分析头皮冷却疗法治疗乳腺癌化疗诱导脱发的效果和安全性。

方法

本研究为前瞻性研究。选择2016年10月至2018年5月中国医科大学附属盛京医院乳腺外科收治的124例接受化疗的乳腺癌患者作为研究对象,随机分为对照组和干预组各62例。在化疗期间,对照组患者给予常规化疗护理和治疗,干预组患者在其基础上应用头皮冷却装置进行持续性冷敷,观察头皮冷却疗法的安全性。采用Mann-Whitney U检验比较2组患者完成4个周期化疗后的脱发情况,采用t检验分析2组患者间化疗后身体意象和生命质量评分的差异。

结果

(1)研究过程中,有5例患者因无法耐受化疗不良反应而拒绝继续进行化疗,2例因无法耐受头痛而退出研究。化疗完成后,最终有117例患者纳入分析,其中干预组57例,对照组60例。干预组中有28例1级脱发,29例2级脱发;对照组中有5例1级脱发,55例2级脱发。与对照组相比,干预组脱发情况得到显著改善(Z=4.880,P<0.001)。(2)应用身体意象量表(BIS)和南丁格尔症状评估量表(N-SAS)对2组患者的身体意象和生命质量进行评估,结果显示:在化疗后,干预组患者身体意象评分为(7.6±5.2)分、社交情况评分为(1.3±1.4)分,而对照组患者身体意象评分为(9.5±5.2)分、社交情况评分为(1.9±1.7)分,2组比较,差异均有统计学意义(t=-2.039、-2.010,P均<0.050)。(3)头皮冷却治疗的不良反应发生率为29.8%(17/57),表现为头痛、头皮寒冷、感觉异常、头晕、恶心、寒战,无严重不良反应。

结论

乳腺癌患者在化疗过程中应用头皮冷却装置能有效降低脱发的发生率,并有助于改善患者的身体意象和生命质量,具有临床应用价值。

Objective

To analyze the effect and safety of scalp cooling therapy on chemotherapy-induced alopecia in breast cancer patients.

Methods

This was a prospective study. Totally 124 breast cancer patients who received chemotherapy in the Department of Breast Surgery, the Shengjing Hospital of China Medical University from October 2016 to May 2018 were enrolled and randomized into the control group and intervention group, 62 patients in each group. During chemotherapy, patients in the control group were given routine care and treatment, while a scalp cooling device was used for continuous cold compress in the patients of intervention group and the safety of this therapy was monitored. The Mann-Whitney U test was used to compare the incidence of hair loss after 4 cycles of chemotherapy between two groups. The t test was used to compare the body image and life quality scores between two groups after the chemotherapy.

Results

(1)During the study, five patients refused to continue chemotherapy because of adverse reactions, and two patients withdrew from the study because of headache. After chemotherapy, 117 patients completed this experiment (57 in the intervention group and 60 in the control group). There were 28 cases of grade 1 hair loss and 29 cases of grade 2 hair loss in the intervention group, 5 and 55 in the control group. The hair loss in the interventional group was significantly improved compared with the control group(Z=4.880, P<0.050). (2)The body image scale (BIS) and Nightingale Symptom Assessment Scale (N-SAS) were used to evaluate the body image and life quality of patients. The results showed that the scores of BIS and N-SAS in the intervention group were significantly lower than those in the control group after chemotherapy (7.6±5.2 vs 9.5±5.2, 1.3±1.4 vs 1.9±1.7, t=-2.039, -2.010, both P<0.050). (3)The incidence of adverse reactions was 29.8%(17/57). The patients reported headache, coldness in scalp, paresthesia, dizziness, nausea and chills. There were no serious adverse reactions.

Conclusion

In breast cancer patients undergoing chemotherapy, the scalp cooling device can effectively reduce the incidence of hair loss and improve the body image and quality of life, worthy of clinical application.

图1 乳腺癌化疗患者实施头皮冷却疗法时佩戴冰帽的方式
图2 电子冰帽调控界面
表1 2组乳腺癌患者一般资料
表2 2组乳腺癌患者脱发情况比较[例(%)]
表3 2组乳腺癌患者身体意向和生命质量评分比较(分,±s)
[1]
曾倩,崔芳芳,宇传华,等.中国癌症发病、死亡现状与趋势分析[J].中国卫生统计,2016,33(2): 321-323.
[2]
Trusson D, Pilnick A. The role of hair loss in cancer identity: perceptions of chemotherapy-induced alopecia among women treated for early-stage breast cancer or ductal carcinoma in situ[J]. Cancer Nurs,2017,40(2): E9-E16.
[3]
薛翠翠,刘均娥.乳腺癌患者体像及心理干预的研究进展[J].中华护理杂志,2015,50(6): 728-732.
[4]
Roila F, Lupattelli M, Sassi M, et al. Intra and interobserver variability in cancer patients’ performance status assessed according to Karnofsky and ECOG scales[J]. Ann Oncol,1991,2(6): 437-439.
[5]
Polo LHV, de Moraes MW. The Zubrod performance status and the Karnofsky index in quality of life evaluation of children with cancer[J]. Einstein, 2009, 7(3 Pt 1): 314-321.
[6]
Fehr MK, Welter J, Sell W,et al. Sensor-controlled scalp cooling to prevent chemotherapy-induced alopecia in female cancer patients[J].Curr Oncol,2016,23(6): 576-582.
[7]
Rugo HS, Klein P, Melin SA, et al. Association between use of a scalp cooling device and alopecia after chemotherapy for breast cancer[J].JAMA,2017,317(6): 606-614.
[8]
Ekwall EM, Nygren LM, Gustafsson AO,et al. Determination of the most effective cooling temperature for the prevention of chemotherapy-induced alopecia[J].Mol Clin Oncol,2013,1(6): 1065-1071.
[9]
Kuse M, Abraham J. Management of chemotherapy-induced alopecia with scalp cooling [J].J Oncol Pract,2018,14(3): 149-154.
[10]
Liu YJ, Zhu GP, Guan XY. Comparison of the NCI-CTCAE version 4.0 and version 3.0 in assessing chemoradiation-induced oral mucositis for locally advanced nasopharyngeal carcinoma [J].Oral Oncol,2012,48(6): 554-559.
[11]
张萍,陈菲菲,连晓杰,等.中文版乳腺癌患者性调节和身体意象量表的评价[J].护理学杂志,2013,28(15): 34-36.
[12]
蔡婷婷,曹梅娟.乳腺癌病人身体意象评估工具的研究进展[J].护理研究,2016,30(31): 3841-3844.
[13]
Can G, Aydiner A. Development and validation of the Nightingale Symptom Assessment Scale (N-SAS) and predictors of the quality of life of the cancer patients in Turkey[J]. Eur J Oncol Nurs,2011,15(1): 3-11.
[14]
Üstündağ S, Zencirci AD. Factors affecting the quality of life of cancer patients undergoing chemotherapy: A questionnaire study[J]. Asia Pac J Oncol Nurs,2015,2(1): 17-25.
[15]
李明卉,夏添松,王水.乳腺癌常用化疗药物的作用机制及血液学不良反应的研究进展[J/CD].中华乳腺病杂志(电子版),2017,11(3): 186-190.
[16]
Zdenkowski N, Tesson S, Lombard J, et al. Supportive care of women with breast cancer: Key concerns and practical solutions[J].Med J Aust,2016,205(10): 471-475.
[17]
Nanqia J. Quality of life matters:it is time to integrate scalp cooling in routine clinical practice[J].J Oncol Pract,2018,14(3): 157-158.
[18]
金春光.紫杉醇序贯化疗治疗乳腺癌患者疗效及毒副反应分析[J].中国实用医药,2017,12(3): 108-110.
[19]
杨慧.肿瘤患者化疗药物所致脱发的防治研究进展[J].肿瘤预防与治疗,2020,33(2): 196-202.
[20]
Hershman DL. Scalp cooling to prevent chemotherapy-induced alopecia:the time has come[J].JAMA,2017,317(6): 587-588.
[21]
Nanqia J, Wang T, Oborne C,et al. Effect of a scalp cooling device on alopecia in women undergoing chemotherapy for breast cancer:the scalp randomized clinical trial[J].JAMA,2017,317(6): 596-605.
[22]
Belum VR, de Barros Silva G, Laloni MT,et al. Cold thermal injury from cold caps used for the prevention of chemotherapy-induced alopecia[J].Breast Cancer Res Treat,2016,157(2): 395-400.
[23]
Rugo HS, Melin SA, Voiqt J. Scalp cooling with adjuvant/neoadjuvant chemotherapy for breast cancer and the risk of scalp metastases:systematic review and meta-analysis[J].Breast Cancer Res Treat,2017,163(2): 199-205.
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