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中华乳腺病杂志(电子版) ›› 2020, Vol. 14 ›› Issue (02) : 120 -123. doi: 10.3877/cma.j.issn.1674-0807.2020.02.012

所属专题: 文献

综述

MammaPrint的研究进展
闫帅1, 陶维阳1,(), 张国强1   
  1. 1. 150081 哈尔滨医科大学附属肿瘤医院乳腺外科
  • 收稿日期:2018-11-09 出版日期:2020-04-01
  • 通信作者: 陶维阳
  • 基金资助:
    黑龙江省自然科学基金面上项目(H2016052)

Research progress of MammaPrint assay

Shuai Yan1, Weiyang Tao1(), Guoqiang Zhang1   

  • Received:2018-11-09 Published:2020-04-01
  • Corresponding author: Weiyang Tao
引用本文:

闫帅, 陶维阳, 张国强. MammaPrint的研究进展[J/OL]. 中华乳腺病杂志(电子版), 2020, 14(02): 120-123.

Shuai Yan, Weiyang Tao, Guoqiang Zhang. Research progress of MammaPrint assay[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2020, 14(02): 120-123.

乳腺癌是高度异质性疾病,即使临床分期及病理分级相同的患者,对治疗的反应和预后可能会大不相同。可能有相当比例的早期乳腺癌患者在没有明显获益的情况下,接受了不必要的辅助治疗。应用高通量基因测序分析技术,通过对特定"靶基因群"表达水平的检测,来提供更准确的预后信息,为选择治疗方案提供参考,是肿瘤精准治疗的重要研究方向。目前,已经研发出多个乳腺癌基因检测系统。其中,较有影响力、潜在价值较高且获美国FDA批准的2个多基因检测系统分别是Oncotype DX基因检测系统和MammaPrint基因检测系统。笔者详细地介绍了MammaPrint基因检测系统的开发、回顾性验证及大型前瞻性临床试验MINDACT研究,并对该系统的成本效益进行了分析。

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