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中华乳腺病杂志(电子版) ›› 2019, Vol. 13 ›› Issue (05) : 305 -308. doi: 10.3877/cma.j.issn.1674-0807.2019.05.010

所属专题: 文献

综述

多西他赛药物代谢酶单核苷酸多态性对乳腺癌化疗的影响
王欣竹1, 蔡莉1,()   
  1. 1. 150081 哈尔滨医科大学附属肿瘤医院内四科
  • 收稿日期:2017-10-25 出版日期:2019-10-01
  • 通信作者: 蔡莉

Effect of single nucleotide polymorphisms of docetaxel-metabolizing enzyme on chemotherapy of breast cancer

Xinzhu Wang1, Li Cai1()   

  • Received:2017-10-25 Published:2019-10-01
  • Corresponding author: Li Cai
引用本文:

王欣竹, 蔡莉. 多西他赛药物代谢酶单核苷酸多态性对乳腺癌化疗的影响[J]. 中华乳腺病杂志(电子版), 2019, 13(05): 305-308.

Xinzhu Wang, Li Cai. Effect of single nucleotide polymorphisms of docetaxel-metabolizing enzyme on chemotherapy of breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2019, 13(05): 305-308.

多西他赛是紫杉醇的半合成类似物,为乳腺癌辅助化疗的常用药物。然而,与其他化疗药物一样,多西他赛存在剂量依赖性或剂量限制性个体差异,因此限制了其在临床治疗上的应用。近年来,大量国内外相关文献提示,由遗传变异所致的药物代谢酶的单核苷酸多态性(SNPs)是引起个体化疗差异的重要原因之一。笔者主要就影响多西他赛体内代谢相关酶的SNPs及其与乳腺癌化疗疗效、不良反应间的关系和意义作一综述。

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