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中华乳腺病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (05) : 315 -318. doi: 10.3877/cma.j.issn.1674-0807.2018.05.012

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胎盘特异性基因1与乳腺癌
刘东洋1, 陈风1,()   
  1. 1. 200233 上海交通大学附属第六人民医院普通外科
  • 收稿日期:2016-11-28 出版日期:2018-10-01
  • 通信作者: 陈风
  • 基金资助:
    浦东新区科技发展基金资助项目(PKJ2016-54)

Placenta-specific gene 1 and breast cancer

Dongyang Liu1, Feng Chen1()   

  • Received:2016-11-28 Published:2018-10-01
  • Corresponding author: Feng Chen
引用本文:

刘东洋, 陈风. 胎盘特异性基因1与乳腺癌[J]. 中华乳腺病杂志(电子版), 2018, 12(05): 315-318.

Dongyang Liu, Feng Chen. Placenta-specific gene 1 and breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2018, 12(05): 315-318.

乳腺癌是造成女性死亡的主要原因之一,然而,其治疗及预后仍然面临重大挑战。胎盘特异性基因1(PLAC1)在胎盘以外的正常组织中基本不表达,但在多种肿瘤细胞中均有表达,在乳腺癌细胞中表达尤其丰富,可能与乳腺癌细胞的增殖、浸润及转移相关。PLAC1作为肿瘤特异性抗原,具有免疫原性,能诱导机体产生免疫应答,为乳腺癌的治疗提供了新的思路。针对PLAC1抗原表位的免疫治疗,可能具有重要的临床价值。笔者就PLAC1在乳腺癌中的研究现状进行介绍和分析。

图1 胎盘特异性基因1(PLAC1)的结构[6,7]及其在乳腺癌中的作用机制[7,14,15,16,17]
[1]
闫光华,罗彬,肖绍文, 等. 胎盘特异性基因PLAC1与肿瘤[J]. 生命的化学, 2010, 30(3): 459-463.
[2]
陈静,庞学雯,刘芳芳, 等. 肿瘤/胎盘抗原基因PLAC1/CP1在胃癌中的表达及其诱导的体液免疫应答[J]. 北京大学学报(医学版), 2006, 38(2): 124-127.
[3]
Silva WA Jr,Gnjatic S,Ritter E, et al. PLAC1, a trophoblast-specific cell surface protein, is expressed in a range of human tumors and elicits spontaneous antibody responses[J]. Cancer Immun, 2007, 7: 18.
[4]
Li Y,Li J,Wang Y, et al. Roles of cancer/testis antigens (CTAs) in breast cancer [J]. Cancer Lett, 2017, 399: 64-73.
[5]
Gu G,Dustin D,Fuqua SA. Targeted therapy for breast cancer and molecular mechanisms of resistance to treatment[J]. Curr Opin Pharmacol, 2016, 31: 97-103.
[6]
Cocchia M,Huber R,Pantano S, et al. PLAC1, an Xq26 gene with placenta-specific expression [J]. Genomics, 2000, 68(3): 305-312.
[7]
Chen Y,Moradin A,Schlessinger D, et al. RXRa and LXR activate two promoters in placenta- and tumor-specific expression of PLAC1 [J]. Placenta, 2011, 32(11): 877-884.
[8]
Liu F,Shen D,Kang X, et al. New tumour antigen PLAC1/CP1, a potentially useful prognostic marker and immunotherapy target for gastric adenocarcinoma[J]. J Clin Pathol, 2015, 68(11): 913-916.
[9]
赵瑞,李世拥,安萍, 等. PLAC1在结直肠癌及其肝转移组织中的表达及临床意义[J/CD]. 中华普外科手术学杂志(电子版), 2012, 6(3): 281-285.
[10]
Devor EJ,Leslie KK.The oncoplacental gene placenta-specific protein 1 is highly expressed in endometrial tumors and cell lines[J]. Obstet Gynecol Int, 2013, 2013: 807849.
[11]
Koslowski M,Sahin U,Mitnacht-Kraus R, et al. A placenta-specific gene ectopically activated in many human cancers is essentially involved in malignant cell processes [J]. Cancer Res, 2007, 67(19): 9528-9534.
[12]
Fant M,Barerra-Saldana H,Dubinsky W, et al. The PLAC1 protein localizes to membranous compartments in the apical region of the syncytiotrophoblast[J]. Mol Reprod Dev, 2007, 74(7): 922-929.
[13]
Ghods R,Ghahremani MH,Darzi M, et al. Immunohistochemical characterization of novel murine monoclonal antibodies against human placenta-specific 1[J]. Biotechnol Appl Biochem, 2014, 61(3): 363-369.
[14]
Koslowski M,Tureci O,Biesterfeld S, et al. Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2[J]. J Biol Chem, 2009, 284(42): 28 607-28 615.
[15]
Wagner M,Koslowski M,Paret C, et al. NCOA3 is a selective co-activator of estrogen receptor α-mediated transactivation of PLAC1 in MCF-7 breast cancer cells[J]. BMC Cancer, 2013, 13: 570.
[16]
Yuan H,Lu J,Xiao J, et al. PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation [J]. Cancer Res, 2013, 73(14): 4349-4361.
[17]
Chen Y,Schlessinger D,Nagaraja R. T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts[J]. Oncogenesis, 2013, 2(9): e67.
[18]
Wu Y,Lin X,Di X, et al. Oncogenic function of Plac1 on the proliferation and metastasis in hepatocellular carcinoma cells [J]. Oncol Rep, 2017, 37(1): 465-473.
[19]
范宜娟,杜光烨,杨滢瑜, 等. 原发性胃腺癌中PLAC1/CP1的表达及临床意义[J]. 现代肿瘤医学, 2016, 24(5): 0770-0774.
[20]
Chang WL,Yang Q,Zhang H, et al. Role of placenta-specific protein 1 in trophoblast invasion and migration [J]. Reproduction, 2014, 148(4): 343-352.
[21]
Devor EJ. Placenta-specific protein 1 is conserved throughout the Placentalia under purifying selection [J]. Sci World J, 2014, 2014: 537 356.
[22]
Old LJ. Cancer is a somatic cell pregnancy[J]. Cancer Immun, 2007, 7: 19.
[23]
Dong XY,Peng JR,Ye YJ, et al. Plac1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients[J]. Int J Cancer, 2008, 122(9): 2038-2043.
[24]
Liu W,Zhai M,Wu Z, et al. Identification of a novel HLA-A2-restricted cytotoxic T lymphocyte epitope from cancer-testis antigen PLAC1 in breast cancer[J]. Amino Acids, 2012, 42(6): 2257-2265.
[25]
Liu F,Zhang H,Shen D, et al. Identification of two new HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from colorectal carcinoma-associated antigen PLAC1/CP1[J]. J Gastroenterol, 2014, 49(3): 419-426.
[26]
Yuan HY,Glazer R,Wang XY, et al. Placental protein-1 (plac1) modulates immune tolerance in mammary tumor cells [J]. J Immunother Cancer, 2015, 3 Suppl 2: 221.
[27]
Stagg J,Allard B. Immunotherapeutic approaches in triple negative breast cancer: latest research and clinical prospects [J]. Ther Adv Med Oncol, 2013, 5(3): 169-181.
[28]
张欢,吴斌. 乳腺癌免疫治疗的研究进展[J/CD]. 中华乳腺病杂志(电子版), 2015, 9(4): 264- 269.
[29]
Hendrickx W,Al-Muftah M,Decock J, et al. Cancer testis antigen expression in triple negative breast cancer: Candidate targets for cancer immunotherapy? [J]. J Immunother Cancer, 2015, 3 Suppl 2: 381.
[30]
Liu FF,Dong XY,Pang XW, et al. The specific immune response to tumor antigen CP1 and its correlation with improved survival in colon cancer patients [J]. Gastroenterology, 2008, 134(4): 998-1006.
[31]
Lee CL,Huang CJ,Yang SH, et al. Discovery of genes from feces correlated with colorectal cancer progression [J]. Oncol Lett, 2016, 12(5): 3378-3384.
[32]
Devor EJ,Santillan DA,Santillan MK, et al. Placenta-specific protein 1 (PLAC1): An ancient and crucial element in placental health and development and a potential therapeutic target in uterine and ovarian cancers[J]. Am J Phy Anthropol, 2015, 156: 120.
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