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中华乳腺病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (05) : 315 -318. doi: 10.3877/cma.j.issn.1674-0807.2018.05.012

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胎盘特异性基因1与乳腺癌
刘东洋1, 陈风1,()   
  1. 1. 200233 上海交通大学附属第六人民医院普通外科
  • 收稿日期:2016-11-28 出版日期:2018-10-01
  • 通信作者: 陈风
  • 基金资助:
    浦东新区科技发展基金资助项目(PKJ2016-54)

Placenta-specific gene 1 and breast cancer

Dongyang Liu1, Feng Chen1()   

  • Received:2016-11-28 Published:2018-10-01
  • Corresponding author: Feng Chen
引用本文:

刘东洋, 陈风. 胎盘特异性基因1与乳腺癌[J/OL]. 中华乳腺病杂志(电子版), 2018, 12(05): 315-318.

Dongyang Liu, Feng Chen. Placenta-specific gene 1 and breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2018, 12(05): 315-318.

乳腺癌是造成女性死亡的主要原因之一,然而,其治疗及预后仍然面临重大挑战。胎盘特异性基因1(PLAC1)在胎盘以外的正常组织中基本不表达,但在多种肿瘤细胞中均有表达,在乳腺癌细胞中表达尤其丰富,可能与乳腺癌细胞的增殖、浸润及转移相关。PLAC1作为肿瘤特异性抗原,具有免疫原性,能诱导机体产生免疫应答,为乳腺癌的治疗提供了新的思路。针对PLAC1抗原表位的免疫治疗,可能具有重要的临床价值。笔者就PLAC1在乳腺癌中的研究现状进行介绍和分析。

图1 胎盘特异性基因1(PLAC1)的结构[6,7]及其在乳腺癌中的作用机制[7,14,15,16,17]
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